Ultrastructural Findings in the Primate Eye After Intravitreal Injection of Bevacizumab

Peters, Swaantje; Heiduschka, Peter; Julien, Sylvie; Ziemssen, Focke; Fietz, Heike; Bartz‐Schmidt, Karl Ulrich; Schraermeyer, Ulrich

doi:10.1016/j.ajo.2007.03.007

Cited by 214 publications

(157 citation statements)

References 23 publications

Supporting

Mentioning

140

Contrasting

Unclassified

Order By: Relevance

“…However, it should be noted that although no evidence of retinal toxicity can be observed by light microscopy, mitochondrial disruption in the inner segments of photoreceptors (detected by electron microscopy) and a high rate of apoptosis have been reported in rabbit eyes following the intravitreal administration of bevacizumab [59]. In addition, intravitreal bevacizumab significantly reduces choriocapillaris endothelial cell fenestration in primate eyes [60]. These findings could have clinical implications, since the long-term neutralisation of retinal VEGF may have unintended consequences, including loss of neural retina cells and increased risk of circulation disturbances in the choriocapillaris [61].…”

Section: Ocular Adverse Effectsmentioning

confidence: 99%

Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy

2008

View full text Add to dashboard Cite

show abstract

Section: Ocular Adverse Effectsmentioning

confidence: 99%

Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy

2008

View full text Add to dashboard Cite

show abstract

“…We recently demonstrated a paracrine relationship between Müller cell-derived VEGF and VEGFR2 expressing photoreceptors in the murine retina (14). The physiologic importance of this relationship was evidenced by a significant loss of photoreceptors following systemic VEGF inhibition (11).…”

mentioning

confidence: 99%

“…The CC of the eye has been shown to be similarly vulnerable to VEGF inhibition. Decreased fenestrations and vessel occlusion were observed after intravitreal injection of anti-VEGF (bevacizumab) in primate eyes (11).…”

mentioning

confidence: 99%

An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris

Saint‐Geniez

Kurihara

Sekiyama

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

454

335

View full text Add to dashboard Cite

Clinical and experimental observations indicate a role for VEGF secreted by the retinal pigment epithelium (RPE) in the maintenance of the choriocapillaris (CC). VEGF in mice is produced as three isoforms, VEGF120, VEGF164, and VEGF188, that differ in their ability to bind heparan sulfate proteoglycan. RPE normally produces the more soluble isoforms, VEGF120 and VEGF164, but virtually no VEGF188, reflecting the fact that molecules secreted by the RPE must diffuse across Bruch's membrane (BrM) to reach the choriocapillaris. To determine the role of RPE-derived soluble VEGF on the choriocapillaris survival, we used mice that produce only VEGF188. VEGF188/188 mice exhibited normal choriocapillaris development. However, beginning at 7 months of age, we observed a progressive degeneration characterized by choriocapillaris atrophy, RPE and BrM abnormalities, culminating in areas of RPE loss and dramatic choroidal remodeling. Increased photoreceptor apoptosis in aged VEGF188/188 mice led to a decline in visual acuity as detected by electroretinogram (ERG). These changes are reminiscent of geographic atrophy (GA) and point to a role for RPE-derived VEGF in the maintenance of the choriocapillaris.age-related macular degeneration ͉ Bruch's membrane ͉ geographic atrophy ͉ retinal pigmented epithelium

show abstract

“…These observations led us to hypothesize that bevacizumab blocks VEGF, which is essential for choroidal vascular physiologic activity, and leads to reduced permeability and consequent choroidal thinning. In fact, fenestration of the choriocapillaris endothelium rapidly decreased 2 weeks after IVB was administered in monkey eyes, although the fenestration recovered to almost 80% of the baseline level 2 weeks after injection [37].…”

Section: Discussionmentioning

confidence: 99%

Transient Choroidal Thinning after Intravitreal Bevacizumab Injection for Myopic Choroidal Neovascularization

Sayanagi¹,

Jo²,

Ikuno³

2011

J Clinic Experiment Ophthalmol

View full text Add to dashboard Cite

Ultrastructural Findings in the Primate Eye After Intravitreal Injection of Bevacizumab

Cited by 214 publications

References 23 publications

Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy

Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy

An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris

Transient Choroidal Thinning after Intravitreal Bevacizumab Injection for Myopic Choroidal Neovascularization

Contact Info

Product

Resources

About