Ultrastructural examination of experimentally induced premalignant lesions

Ferguson, John W.; McMillan, M.D.; Smillie, A. C.

doi:10.1016/s0901-5027(05)80721-0

Cited by 3 publications

(1 citation statement)

References 43 publications

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“…Evidence of focal basal lamina multilayering/reduplication/thickening has been previously reported in experimental carcinogenesis [8,11] as well as in human oral SCC [12,13]. In general, this can be explained in terms of either an increased turnover with synthesis of additional cellular/extracellular products by the cells exposed to micro-environmental insults, or may reflect the cellular response to the dysplastic changes [14].…”

Section: Discussionmentioning

confidence: 86%

4NQO-Induced Rat Tongue Carcinoma: An Ultrastructural Study

Vered

Polak‐Charcon

Babushkin

et al. 2008

Ultrastructural Pathology

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The 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinoma, in which the carcinogen is administered systemically in drinking water, is the most comparable animal model to the development of human oral carcinoma. This is the first study to report the ultrastructural changes in this model. The most significant changes were observed in the carcinoma cells at the invasion front and included unique modifications in the basal lamina, presence of micropinocytotic vesicles (plasmalemmal caveolae), and emergence of cytoplasmic microfilaments featuring a parallel arrangement. The microfilaments, in both appearance and organization, were consistent with contractile microfilaments. These observations may be the morphological reflection of the phenotypic modifications occurring within the carcinoma cells, approaching smooth muscle differentiation.

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