Ultrastructural effects of nerve growth factor and betamethasone on nerve regeneration after experimental nerve injury

Sencar, Leman; Güven, Mustafa; Şaker, Dilek; Sapmaz, Tuğçe; Tuli, Abdullah; Polat, Sait

doi:10.1080/01913123.2020.1850965

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…The antiinflammatory effect of local betamethasone after spinal root decompression in cats was seen by Wong and Tan [ 20 ], noting the relative absence of cytokine differentiation antigens 4- and 5-labelled lymphocytes at the compression site in the steroid-treated group. Sencar et al [ 21 ] investigated the antiinflammatory effect of betamethasone on crushed sciatic nerves in rats and found that combing the nerve growth factor with betamethasone resulted in rapid functional recovery. Al-Bishri et al [ 22 ] identified a beneficial effect of betamethasone on the recovery of damaged sciatic nerves in rats, as reflected in the recruitment of macrophages and the expression of the p75 nerve growth factor receptor.…”

Section: Discussionmentioning

confidence: 99%

Effect of betamethasone injection into the pterygomandibular space on the neurosensory disturbance after bilateral sagittal split ramus osteotomy: a pilot study

Hamad,

Khrwatany,

Mohammed

et al. 2024

Eur J Med Res

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Aim The aim of this study was to evaluate the effect of local betamethasone injection into the pterygomandibular space on postoperative neurosensory deficits. Materials and methods A prospective controlled clinical study was conducted on 16 patients (6 male, 10 female; mean age, 24.95 ± 9.22 years) who underwent bilateral sagittal ramus osteotomy for mandibular discrepancies. One side of each patient’s mandible was randomly selected as the control side, and the opposite side as the experimental side. On the experimental side, a solution of betamethasone (6 mg/1 ml) was injected into the pterygomandibular space after the completion of wound closure. Neurosensory tests, including light touch, two-point discrimination, direction of movement, thermal sensitivity, and pin-prick discrimination, were performed. The follow-up period ranged between 6 and 12 months, according to the particular sensory test. The Fisher exact test was used to analyse the data. Results The light touch sensation was abnormal in 75% of the control side and 31% of the study side, with the difference being significant (p = 0.03). However, at 6 months, all the study cases regained touch sensation, compared to 69% of the control side. No significant difference in direction movement discrimination was seen; however, at 3 months, the study side showed significantly less direction sensation (19%) compared to the control side (56%) (p = 0.02). There was no significant difference in the two-point discrimination; however, at 3 months, the study side had a significantly less abnormal two-point sensation (13%) than the control side (56%) (p = 0.02). In addition, no significant difference was noted in thermal sensitivity or pin-prick sensation. Conclusion Betamethasone injection into the pterygomandibular space reduces neurosensory disturbances after bilateral sagittal split ramus osteotomies nd leads to faster recovery of sensations.

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Section: Discussionmentioning

confidence: 99%

Effect of betamethasone injection into the pterygomandibular space on the neurosensory disturbance after bilateral sagittal split ramus osteotomy: a pilot study

Hamad,

Khrwatany,

Mohammed

et al. 2024

Eur J Med Res

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“…У перші 2 дні після травми спостерігається витік внутрішньоаксональної рідини з розірваного аксона, нарос тає набряк д и с т а л ь н о г о в і д р і з к а, п о с т у п о в о з н и к а ю т ь нейрофібрили. У тілі нейрона ядро перикаріона збільшується в об'ємі та зміщується до периферії [30]. Навколо ядра спостерігається розпад і розчинення тілець Ніссля, що виявляється втратою фарбування катіонними барвниками.…”

Section: класифікація ушкоджень нерваunclassified

“…Якщо ендоневральна трубка не отримала аксон, то вона повніс тю виповнює ться фіброзною тканиною. Відновлення функції тканини-мішені можливе лише частково, у деяких випадках потребує хірургічного лікування [30,32,34,[39][40][41].…”

Section: класифікація ушкоджень нерваunclassified

Peripheral nerve traction injury. Literature review

Tsymbaliuk,

Vorodi,

Petriv

et al. 2023

Ukr Neurosurg J

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Traction injury of the peripheral nerve (TIPN) is an injury that occurs as a result of stretching the nerve beyond its normal elastic properties. An analysis of the available literature has revealed the following. TIPN is the most common type of severe nerve injury in the setting of road traffic accidents, catatrauma, gunshot wounds, birth injuries, etc. The dynamics of TIPN during fast and slow stretching is the same and includes three phases: elastic, inelastic and tearing. The limits of elastic stretching of the nerve are determined by the degree of tortuosity of myelinated fibers and the elasticity of the connective tissue framework of the nerve. Stretching of the nerve beyond its elastic limits is characterized by rupture of axons and endoneurial sheaths, including at a considerable distance from the epicenter of pathomorphological changes, which determines the severity of the injury and the impossibility of effective nerve autoregeneration. The force of stretching and the direction of its application to the nerve trunk determine the severity of TIPN. The degree of nerve stretching varies along its length and reaches a maximum in the periarticular areas. A fairly moderate stretching of the nerve can lead to a noticeable change in the conductivity of electrical impulses. Unlike other localized types of nerve injury, the pattern of pathomorphological changes in TIPN includes various forms of damage to structural elements. Understanding the pathophysiology of TIPN is a prerequisite for the development of optimal treatment of this type of injury.

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“…This process is called lipid peroxidation and produces cytotoxic agents, e.g., malondialdehyde (MDA), which cause oxidative stress ( 7 ). It is known that oxidative stress is one of the main causes of neuronal death and axon demyelination after nerve injury ( 8 , 9 ). The injured nerve has a mechanism to neutralize the effect of free radicals.…”

Section: Introductionmentioning

confidence: 99%

Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury

Kongsui

Surapinit

Promsrisuk

et al. 2023

Braz J Med Biol Res

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Oxidative stress plays a role in the delay of peripheral nerve regeneration after injury. The accumulation of free radicals results in nerve tissue damage and dorsal root ganglion (DRG) neuronal death. Pinostrobin (PB) is one of the bioflavonoids from Boesenbergia rotunda and has been reported to possess antioxidant capacity and numerous pharmacological activities. Therefore, this study aimed to investigate the effects of PB on peripheral nerve regeneration after injury. Male Wistar rats were randomly divided into 5 groups including control, sham, sciatic nerve crush injury (SNC), SNC + 20 mg/kg PB, and SNC + 40 mg/kg PB. Nerve functional recovery was observed every 7 days. At the end of the study, the sciatic nerve and the DRG were collected for histological and biochemical analyses. PB treatment at doses of 20 and 40 mg/kg reduced oxidative stress by up-regulating endogenous glutathione. The reduced oxidative stress in PB-treated rats resulted in increased axon diameters, greater number of DRG neurons, and p-ERK1/2 expression in addition to faster functional recovery within 4 weeks compared to untreated SNC rats. The results indicated that PB diminished the oxidative stress-induced nerve injury. These effects should be considered in the treatment of peripheral nerve injury.

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Ultrastructural effects of nerve growth factor and betamethasone on nerve regeneration after experimental nerve injury

Cited by 6 publications

References 33 publications

Effect of betamethasone injection into the pterygomandibular space on the neurosensory disturbance after bilateral sagittal split ramus osteotomy: a pilot study

Effect of betamethasone injection into the pterygomandibular space on the neurosensory disturbance after bilateral sagittal split ramus osteotomy: a pilot study

Peripheral nerve traction injury. Literature review

Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury

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