Ultrastructural effects of anteroventral third ventricle lesions on supraoptic nuclei and neural lobes of rats

Carithers, Jeanine; Dellmann, H. Dieteer; Bealer, Steven L.; Brody, Michael J.; Johnson, Alan Kim

doi:10.1016/0006-8993(81)90208-0

Cited by 29 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An overall view of the neurohypophysis at the electron microscope level revealed that neurosecretory axons in both G86R and wild‐type mice contained numerous NSG, which strongly suggests that the low plasma AVP levels in SOD1 mutant animals cannot be considered to result from depleted pools of hormone in the neural lobe, a situation seen rather after appropriate secretory stimuli (e.g. water‐deprivation) (Carithers et al . 1981; Alonso et al .…”

Section: Discussionmentioning

confidence: 99%

A mouse model of familial amyotrophic lateral sclerosis expressing a mutant superoxide dismutase 1 shows evidence of disordered transport in the vasopressin hypothalamo‐neurohypophysial axis

Aguilar

Gordon

Frydman

et al. 1999

Eur J of Neuroscience

View full text Add to dashboard Cite

Amyotrophic lateral sclerosis (ALS) is a fatal, paralytic disorder that primarily affects motoneurons. By combining physiological and morphological approaches, we examined the effect of a murine superoxide dismutase 1 (SOD1) mutation (G86R), which induces neurological disorders resembling human familial ALS (FALS), on the arginine vasopressin (AVP) hypothalamo-neurohypophysial axis, an unmyelinated tract poor in neurofilaments. First, we observed that G86R mice progressively consumed more water than wild-type littermates. Furthermore, levels of plasma AVP and neurohypophysial AVP content were decreased in the SOD1 mutant mice, whereas the amount of hypothalamic AVP increased in an age-dependent manner. However, hypothalamic AVP mRNA levels were not significantly modified in these animals. At the ultrastructural level, we found that the neurohypophysis of G86R mice had a decreased number of neurosecretory axons. Conversely, the presence of large axon swellings was more pronounced in the SOD1 mutant mice. In addition, the size of neurosecretory granules was higher in G86R than in wild-type animals. All these findings strongly suggest that the FALS-associated SOD1 mutation injures the hypothalamo-neurohypophysial axis by provoking early, progressive disturbances in the axonal transport of neurosecretory products from neuronal perikarya to nerve terminals. This blockade could ultimately result in degeneration of the tract, as proposed for the myelinated, neurofilament-enriched motor axons affected by ALS.

show abstract

Section: Discussionmentioning

confidence: 99%

A mouse model of familial amyotrophic lateral sclerosis expressing a mutant superoxide dismutase 1 shows evidence of disordered transport in the vasopressin hypothalamo‐neurohypophysial axis

Aguilar

Gordon

Frydman

et al. 1999

Eur J of Neuroscience

View full text Add to dashboard Cite

show abstract

“…Therefore, in winter, associated with a reduced hormonal demand, the pituicytes increase their processes number on the BL to enclose nerve fiber terminals. The coverage of BL by neurosecreto- www.fhc.viamedica.pl ry nerve fiber endings is a plastic phenomenon [37,46], and pituicyte processes retract from both areas when hormone demand is high, allowing the neuronal terminals direct access to the perivascular space. Previous studies with neurohypophysis explants have shown that osmotic challenges produce similar modifications [47].…”

Section: Discussionmentioning

confidence: 99%

Adaptation of <i>Camelus dromedarius</i> pars nervosa of the hypophysis to winter and summer living conditions

Alim

Rodrı́guez

Andrade

et al. 2012

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

Abstract:The aim of this work is to study the characteristics of the dromedary nervous lobe and determine how the seasons condition its organization. To this end, electron microscopy was performed and examined quantitatively on animals from winter and summer periods. The results show a higher number of cells in the nervous lobe in summer than in winter. The most abundant glial elements in winter are light pituicytes engulfing neurosecretory nerve fibers making neuroglial contact, and dark pituicytes containing numerous heterogeneous light bodies. In summer, the most distinctive glial cells may be pituicytes in a phagocytic state making contact with characteristic large light bodies that could represent a degenerative process of large neuropeptide storage. Granular pituicytes were also observed in contact with glial and neuronal components. However, lipid droplets, described in pituicytes of other mammals, were not observed in our samples. Quantitative analysis of neurovascular contacts revealed that the number of nerve terminals contacting the basal lamina did not differ between summer and winter, but the mean number of glial processes increased in winter. Our data provides evidence that the storage of neuropeptides is very marked in summer and that, associated with an autophagic and phagocytic phenomenon, this suggests an adaptation to anticipate any situation that would cause dehydration of the dromedary. Thus, in its tough environment, the animal remains permanently prepared to avoid any large water loss.

show abstract

“…1975. Carithers et al [1981] found NSG de pletion in the NLH of water-deprived rats with many axons devoid of neurosecretory granules and containing only electron-lucent vesicles of various sizes, as well as abundant tubular formations, dense and multilamellar bodies, and a decrease of glial structures in the pericapillary basal lamina.…”

Section: Discussionmentioning

confidence: 99%

Morphology of the Neural Lobe of the Hypophysis in Rats Treated with Furosemide

Vazquez¹,

Carretero²,

Domı́nguez³

et al. 1987

Cells Tissues Organs

View full text Add to dashboard Cite

The changes found in the neurosecretory axons of the neural lobe of the hypophysis were studied in rats treated with furosemide for three days: over the whole period of treatment, the animals, according to each group, were deprived or not of water. In the animals with free access to water the axons contained neurosecretory granules with scarce content and low electron density; only some of them had vacuoles and autophagic bodies. In the animals deprived of water axon morphology was variable and axons showing vacuoles and autophagic bodies were abundant, as well as those presenting lamellar and dense bodies and also those in which filaments prevailed. The most outstanding modifications in this last group of animals were related to the dehydration and were not found in those animals which were given access to water again and which were in consequence rehydrated.

show abstract

Ultrastructural effects of anteroventral third ventricle lesions on supraoptic nuclei and neural lobes of rats

Cited by 29 publications

References 24 publications

A mouse model of familial amyotrophic lateral sclerosis expressing a mutant superoxide dismutase 1 shows evidence of disordered transport in the vasopressin hypothalamo‐neurohypophysial axis

A mouse model of familial amyotrophic lateral sclerosis expressing a mutant superoxide dismutase 1 shows evidence of disordered transport in the vasopressin hypothalamo‐neurohypophysial axis

Adaptation of <i>Camelus dromedarius</i> pars nervosa of the hypophysis to winter and summer living conditions

Morphology of the Neural Lobe of the Hypophysis in Rats Treated with Furosemide

Contact Info

Product

Resources

About