Ultrastructural diagnosis of human pituitary adenomas

Horváth, Éva; Kovács, Kálmán

doi:10.1002/jemt.1070200202

Cited by 45 publications

(12 citation statements)

References 82 publications

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“…The MiB-1 index is very low. The ultrastructure is very similar to densely granulated GH cell adenomas, although the secretory granules are larger and more irregular (57). Exocytoses into the intercellular space are demonstrable.…”

Section: Adenomas Secreting Both Gh and Prolactinmentioning

confidence: 73%

“…Additionally, some adenoma cells may contain both GH and PRL (52). The ultrastructure exhibits adenoma cells of the GH cells type and of the PRL cell type (57). In contrast, the monocellular bihormonal mammosomatotrope adenoma (1.1% in our collection; Table 4) is composed of medium-sized to large strongly acidophilic cells in a medullary or diffuse arrangement resembling the densely granulated GH cell adenoma.…”

Section: Adenomas Secreting Both Gh and Prolactinmentioning

confidence: 74%

“…Evaluation of the ultrastructure reveals plurimorphism (57). Another plurihormonal adenoma is the silent subtype 3 adenoma (9, 74, 82, 83) being immunoreactive not only for GH, PRL, and TSH but also for other hormones.…”

Section: Plurihormonal Adenomasmentioning

confidence: 99%

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Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry

Saeger

Lüdecke²,

Buchfelder³

et al. 2007

eur j endocrinol

523

346

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In 1996, the German Registry of Pituitary Tumors was founded by the Pituitary Section of the German Society of Endocrinology as a reference center for collection and consultant pathohistological studies of pituitary tumors. The experiences of the first 10 years of this registry based on 4122 cases will herein be reported. The data supplement former collections of the years 1970-1995 with 3480 surgically removed tumors or lesions of the pituitary region. The cases were studied using histology, immunostainings and in some cases also molecular pathology or electron microscopy. The adenomas were classified according to the current World Health Organization classification in the version of 2004. From 1996 on 3489 adenomas (84.6%), 5 pituitary carcinomas (0.12%), 133 craniopharyngiomas (3.2%), 39 meningiomas (0.94%), 25 metastases (0.6%), 22 chordomas (0.5%), 115 cystic non-neoplastic lesions (2.8%), and 46 inflammatory lesions (1.1%, 248 other lesions or normal tissue (6.0%)) were collected by us. The adenomas (100%) were classified into densely granulated GH cell adenomas (9.2%), sparsely granulated GH cell adenomas (6.3%), sparsely granulated prolactin (PRL) cell adenomas (8.9%), densely granulated PRL cell adenomas (0.3%), mixed GH/PRL cell adenomas (5.2%), mammosomatotropic adenomas (1.1%), acidophilic stem cell adenomas (0.2%), densely granulated ACTH cell adenomas (7.2%), sparsely granulated ACTH cell adenomas (7.9%), Crooke cell adenomas (0.03%), TSH cell adenomas (1.5%), FSH/LH cell adenomas (24.8%), null cell adenomas (19.3%), null cell adenoma, oncocytic variant (5.8%), and plurihormonal adenomas (1.3%).

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Section: Adenomas Secreting Both Gh and Prolactinmentioning

confidence: 73%

Section: Adenomas Secreting Both Gh and Prolactinmentioning

confidence: 74%

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Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry

Saeger

Lüdecke²,

Buchfelder³

et al. 2007

eur j endocrinol

523

346

View full text Add to dashboard Cite

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“…Although there are few reports about these tumors in the literature, they may represent 2±7% of all surgically treated adenomas (1). They present the same histological and ultrastructural features of ACTHsecreting adenomas of the pituitary in Cushing's disease (9). Different hypotheses have been proposed to explain the lack of clinical symptomatology of these tumors such as the defective packaging of tumor ACTH Figure 4 Quantitative in situ hybridization analysis of dopamine D2 receptor mRNA.…”

Section: Discussionmentioning

confidence: 86%

ACTH silent adenoma shrinking under cabergoline

Pétrossians

Ronci

Socin

et al. 2001

European Journal of Endocrinology

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Objectives: The authors present a case report that proposes the use of cabergoline treatment in silent ACTH adenoma, an unusual member of the heterogeneous group of the so-called clinically nonfunctioning pituitary adenomas. Design: Following the clinical and radiological improvement of a recurrent silent ACTH adenoma in a 77-year-old patient treated with cabergoline (0.5 mg every 2 days for 2 years), in vitro studies of the original tumor were performed. Methods: The original tumor from the patient was studied by in situ hybridization and dopamine D2 receptor autoradiography. It was compared with four macroprolactinomas and two macroadenomas from patients with Cushing's disease. Results: The D2 receptor mRNA signal of the reported case was intense and of the same order of magnitude as that observed in control prolactinomas. Dopamine D2 receptor autoradiography was twice that of control corticotroph adenomas and was close to that observed in prolactinomas. Conclusions: This is the first description of an in vivo shrinkage of an ACTH silent adenoma under cabergoline. We demonstrate in vitro, the presence of D2 receptors in the primitive tumor in concentrations similar to those found in control prolactinomas. These results suggest that therapeutic trials with cabergoline might be undertaken in recurring cases of ACTH silent tumors and more generally, non-functioning pituitary adenomas.

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“…The functional classification of pituitary adenomas based on its hormonal activity, assessed by immunohistochemistry technique, and associated with the transmission electron microscopy analysis, has allowed the characterization of neoplastic cells in detail and proposes the classification of the adenomas in 14 different types, this allows a better correlation with the clinical manifestations that the old classification of chromophobe, acidophilic and basophilic pituitary adenomas (Horvath & Kovacs, 1992;Horvath, 1994;Kovacs & Horvath, 1986). …”

mentioning

confidence: 99%