Ultrastructural cytology of regenerating tendon - An experimental study

Katenkamp, D.; Stiller, D; Schulze, E.

doi:10.1016/s0014-4908(76)80030-0

Cited by 8 publications

(2 citation statements)

References 30 publications

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“…Several authors have found that pericytes isolated from different tissues can be induced to differentiate into various connective tissue phenotypes [8]. It seems unlikely that the presence of vascular pericytes in tendon tissue, which might be another multipotent cell source in tendon tissue [28], can account for our findings. Not only is tendon a poorly vascularized tissue, but also the tendon-derived fibroblasts remained negative for pericyte marker α-SMA through the first four passages.…”

Section: Discussionmentioning

confidence: 52%

Intrinsic differentiation potential of adolescent human tendon tissue: an in-vitro cell differentiation study

Mos

Koevoet

Jahr

et al. 2007

BMC Musculoskelet Disord

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Section: Discussionmentioning

confidence: 52%

Intrinsic differentiation potential of adolescent human tendon tissue: an in-vitro cell differentiation study

Mos

Koevoet

Jahr

et al. 2007

BMC Musculoskelet Disord

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“…The niche of these cells is not yet fully understood. The finely tuned molecular and cellular composition of this niche appears to be crucial for stem cell differentiation and maintenance (Bi et al, 2007;Katenkamp et al, 1976;Tempfer et al, 2009;Zhang and Wang, 2013;Zhang et al, 2010b). So far, besides oxygen tension and mechanical stimuli, few other niche-determining factors are known including the composition and nano-/micro-structure of the extracellular matrix (ECM) (Bi et al, 2007;Rui et al, 2011b;Tong et al, 2012;Wang et al, 2008;Zhang and Wang, 2013).…”

Section: Introductionmentioning

confidence: 99%

The blood-tendon barrier: identification and characterisation of a novel tissue barrier in tendon blood vessels

Lehner

Gehwolf²,

Ek³

et al. 2016

eCM

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Tissue barriers function as "gate keepers" between different compartments (usually blood and tissue) and are formed by specialised membrane-associated proteins, localising to the apicolateral plasma membrane domain of epithelial and endothelial cells. By sealing the paracellular space, the free diffusion of solutes and molecules across epithelia and endothelia is impeded. Thereby, tissue barriers contribute to the establishment and maintenance of a distinct internal and external environment, which is crucial during organ development and allows maintenance of an organspecific homeostatic milieu. So far, various epithelial and endothelial tissue barriers have been described, including the blood-brain barrier, the blood-retina barrier, the blood-testis barrier, the blood-placenta barrier, and the cerebrospinal fluid (CSF)-brain barrier, which are vital for physiological function and any disturbance of these barriers can result in severe organ damage or even death. Here, we describe the identification of a novel barrier, located in the vascular bed of tendons, which we term the bloodtendon barrier (BTB). By using immunohistochemistry, transmission electron microscopy, and tracer studies we demonstrate the presence of a functional endothelial barrier within tendons restricting the passage of large blood-borne molecules into the surrounding tendon tissue. We further provide in vitro evidence that the BTB potentially contributes to the creation of a distinct internal tissue environment impacting upon the proliferation and differentiation of tendon-resident cells, effects which might be fundamental for the onset of tendon pathologies.

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Ultrastrukturelle Beobachtungen w�hrend des Umbaus von konservierten homologen Sehnentransplantaten beim Menschen

Józsa¹,

Bálint²

1977

Arch orthop Unfall-Chir

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Authors have investigated the ultrastructural morphology of transformation of homologous human tendon transplants. Tenoblasts and mast cells were found next to collagenous fibres originating in the transplant and disintegrating in the voluminous ground substance. The formation of new collagen tissue was of different grades; areas of only a few fibres and areas with oriented fibres were both present. Twenty months after implantation parts characterised by apparently mature structure were found as well as abundant new fibre formation and mast cells.

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Ultrastructural cytology of regenerating tendon - An experimental study

Cited by 8 publications

References 30 publications

Intrinsic differentiation potential of adolescent human tendon tissue: an in-vitro cell differentiation study

Intrinsic differentiation potential of adolescent human tendon tissue: an in-vitro cell differentiation study

The blood-tendon barrier: identification and characterisation of a novel tissue barrier in tendon blood vessels

Ultrastrukturelle Beobachtungen w�hrend des Umbaus von konservierten homologen Sehnentransplantaten beim Menschen

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