Ultrastructural changes induced by ultraviolet light in human epidermis: Granular and transitional cell layers

Nix, Thomas; Nordquist, Robert E.; Everett, Mark Allen

doi:10.1016/s0022-5320(65)80047-8

Cited by 28 publications

(14 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These same features were revealed in human studies (26)(27)(28). Ultrastructural alterations induced in skin by applica tions of polycyclic hydrocarbons were far more severe, affecting both the nucle ar, cytoplasmic and membranous structures (36,37).…”

Section: Discussionsupporting

confidence: 63%

Cellular Injury and Cell Proliferation in Skin Carcinogenesis by UV Light

Stenbäck¹

1975

Oncology

View full text Add to dashboard Cite

The effects on mouse skin of varying doses of light from a high-voltage mercury lamp were compared to the alterations occurring after repeated light applications from a carbon-arc xenon sunlamp. A single dose of UV light at a carcinogenic wavelength caused necrosis and ulceration, followed by scarring, but failed to produce tumors. In the case of repeated small doses, the neoplastic response was predominantly epithelial, resulting in formation of papillomas and squamous cell carcinomas. Increasing the dose caused formation of fibromas and fibrosarcomas of the ear. However, repeated applications of UV light having a spectrum similar to sunlight failed to induce tumors. In these studies, only animals showing initially destructive lesions ultimately presented tumor formation, while the hyperplasia induced by UV irradiation showed no relationship to neoplastic transformation. The results emphasize the significance of dose and wavelength in evaluating effects of UV-light skin carcinogenesis.

show abstract

Section: Discussionsupporting

confidence: 63%

Cellular Injury and Cell Proliferation in Skin Carcinogenesis by UV Light

Stenbäck¹

1975

Oncology

View full text Add to dashboard Cite

show abstract

“…All other cell organelles were of normal appearance. It has been reported that cells subject to ultra violet light exhibit intracellular vacuolation and irregular dense bodies [8]. However, the opaque bodies observed in the study reported here are regular, not crenated and usually associated with tonofibrils.…”

Section: Discussioncontrasting

confidence: 51%

An Ultrastructural Study of the Keratoacanthoma Treated with Methotrexate and 5-Fluorouracil

Prutkin¹

1968

Dermatology

View full text Add to dashboard Cite

“…Langerhans cells are more sensitive to UV‐induced damage in comparison to keratinocytes for both UVA and UVB wavelengths 66 . The degenerative changes for LC and keratinocytes include mitochondrial swelling and rupture, condensation of the cytoplasm and the appearance of pyknotic nuclei 58 , 66 , 67 , 68 . The observed cellular damage is maximal at 48–72 h for the total UV range 40 .…”

Section: Morphology and Ultrastructural Changesmentioning

confidence: 99%

Ultraviolet light induced injury: Immunological and inflammatory effects

2001

View full text Add to dashboard Cite

Summary This article reviews many of the complex events that occur after cutaneous ultraviolet (UV) exposure. The inflammatory changes of acute exposure of the skin include erythema (sunburn), the production of inflammatory mediators, alteration of vascular responses and an inflammatory cell infiltrate. Damage to proteins and DNA accumulates within skin cells and characteristic morphological changes occur in keratinocytes and other skin cells. When a cell becomes damaged irreparably by UV exposure, cell death follows via apoptotic mechanisms. Alterations in cutaneous and systemic immunity occur as a result of the UV-induced inflammation and damage, including changes in the production of cytokines by keratinocytes and other skin-associated cells, alteration of adhesion molecule expression and the loss of APC function within the skin. These changes lead to the generation of suppressor T cells, the induction of antigen-specific immunosuppression and a lowering of cell-mediated immunity. These events impair the immune system's capacity to reject highly antigenic skin cancers. This review gives an overview of the acute inflammatory and immunological events associated with cutaneous UV exposure, which are important to consider before dealing with the complex interactions that occur with chronic UV exposure, leading to photocarcinogenesis.

show abstract

Ultrastructural changes induced by ultraviolet light in human epidermis: Granular and transitional cell layers

Cited by 28 publications

References 22 publications

Cellular Injury and Cell Proliferation in Skin Carcinogenesis by UV Light

Cellular Injury and Cell Proliferation in Skin Carcinogenesis by UV Light

An Ultrastructural Study of the Keratoacanthoma Treated with Methotrexate and 5-Fluorouracil

Ultraviolet light induced injury: Immunological and inflammatory effects

Contact Info

Product

Resources

About