Ultrastructural changes in rat thyroid tissue after acute organophosphate poisoning and effects of antidotal therapy with atropine and pralidoxime: A single-blind, ex vivo study

Satar, Deniz Aka; Satar, Salim; Mete, Ufuk; Suchard, Jeffrey R.; Topal, Metin; Karakoç, Emre; Kaya, Mehmet

doi:10.1016/j.curtheres.2008.07.001

Cited by 3 publications

(3 citation statements)

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“…Ultrastructural changes in thyroid tissue has been demonstrated in a study on rats with acute methamidophos poisoning suggesting that certain OPC may have direct deleterious effect on thyroid. [ 14 ] In our study, one patient had biochemical profile suggestive of hypothyroidism at admission and the T 4 decreased further with rise in TSH at 3 months of follow up. The TPO was negative and he had normal urinary iodine and no other identifiable cause of hypothyroidism.…”

Section: Discussionmentioning

confidence: 54%

“…Effects of OPCs on cardiovascular, nervous and respiratory systems are well known but their effect on endocrine system is not properly studied. [ 13 14 15 16 ] Hence, this study was planned to evaluate alterations in pituitary-target gland hormones at admission, at discharge following recovery and at three months of follow-up after acute OPC poisoning.…”

Section: Introductionmentioning

confidence: 99%

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Effects of acute organophosphate poisoning on pituitary target gland hormones at admission, discharge and three months after poisoning: A hospital based pilot study

Dutta

Kamath

Bhalla

et al. 2015

Indian J Endocr Metab

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Background:Organophosphate compound (OPC) poisoning is common in the developing countries such as India. The acute and later effects of OPC poisoning on pituitary and target gland hormones is largely unknown.Materials and Methods:This prospective study was conducted at Postgraduate Institute of Medical Education and Research between January 2012 and March 2013. Fourteen patients (8 males, age 18-50 years) with acute OPC poisoning were included in the study based on the history and clinical features, documented decreased in plasma cholinesterase activity or presence of the OPC in gastric lavage/blood samples. The hormonal parameters were done at baseline, at the time of discharge and at three months of follow-up.Results:A total of 14 patients out of 46 with the mean age of 30.1 ± 10.3 years were finally eligible for the study. Hormonal alterations at admission were similar to sick euhormonal syndrome. Overall 7 of them had nine hormonal deficits at three months of follow up, 4 having sub normal basal cortisol level and two each had low testosterone and growth hormone and only one had thyroxine deficiency.Conclusion:Acute organophosphate poisoning results in endocrine dysfunction akin to sick euhormonal syndrome. However, in a small subset of patients, varying level of hormonal insufficiency may occur either at admission or later. These observations need re-validation in a larger group of patients with specific OPC.

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Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Effects of acute organophosphate poisoning on pituitary target gland hormones at admission, discharge and three months after poisoning: A hospital based pilot study

Dutta

Kamath

Bhalla

et al. 2015

Indian J Endocr Metab

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“…O pesticida, Metamidofós, teve indicações de sua proibição no Brasil, e de acordo com Marinho (2010), este contém elevado e comprovado grau de toxicidade que causa problemas para os sistemas reprodutivos, neurológicos, reprodutivos e até câncer. Em seus estudos, Satar et al, (2008) observaram alterações ultraestruturais em tecidos da tireóide de ratos, em decorrência de intoxicações pelo inseticida metamidofós.…”

Section: Resultsunclassified

Resíduos de agrotóxicos em alimentos: preocupação ambiental e de saúde para população paraibana

Ismael¹,

Rocha²,

Filho³

et al. 2015

Revista Verde

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O monitoramento de resíduos de agrotóxicos em alimentos vem assumindo grande importância para o alcance à segurança alimentar dos consumidores. A Paraíba é hoje um grande consumidor de legumes, verduras e frutas no Brasil, detentora de grandes áreas de diversas monoculturas. O presente trabalho visou investigar os resíduos de agrotóxicos em alimentos comercializados no Estado da Paraíba e seus impactos negativos a saúde humana. A partir de visitas feitas em parceria com a Agência Estadual de Vigilância Sanitária (AGEVISA-PB), foram coletadas 100 amostras de 15 diferentes culturas durante os anos de 2011, 2012 e 2013 em vários supermercados da Paraíba e encaminhadas a laboratórios credenciados, onde foram investigados aproximadamente 234 diferentes ingredientes ativos de agrotóxicos em alimentos. Verificou-se que de 100 amostras de alimentos analisadas, 55 % possuem resíduos de agrotóxicos. Através da identificação dos possíveis riscos a saúde humana e ao meio ambiente, resultantes de níveis de agrotóxicos acima do permitido para o consumo humano, podem-se indicar medidas preventivas e mais sustentáveis que reduzam os possíveis impactos, como por exemplo: campanhas de orientação para os produtores, incentivo ao manejo ambientalmente correto do solo e fiscalizações mais rígidas junto aos comerciantes destes produtos.Pesticide residues in food: environmental concerns and health requirements for paraibana populationABSTRACT - The Monitoring of pesticide residues in food is of great importance for achieving food security of consumers. The Paraíba is now a major consumer of vegetables and fruits in Brazil, which owns large areas of several monocultures. This study aimed to investigate the pesticide residues in foods marketed in the State of Paraíba and its negative impacts on human health. From visits in partnership with the State Agency for Sanitary Surveillance (AGEVISA-PB), 100 samples of 15 different cultures were collected during the years 2011, 2012 and 2013 in various supermarkets of Paraíba and sent to accredited laboratories, where they were investigated about 234 different pesticide active ingredients in foods. It was found that 100 food samples analyzed, 55% had pesticide residues. By identifying the possible risks to human health and the environment resulting from pesticide levels above the permitted for human consumption, can be indicated more preventive and sustainable measures to reduce the possible impacts, such as: orientation campaigns producers, encouraging environmentally friendly soil management and stricter inspections along the traders of these products.

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Polyethyleneglycol-serine nanoparticles as a novel antidote for organophosphate poisoning: synthesis, characterization, in vitro and in vivo studies

Ebrahimnejad

Davoodi

Irannejad

et al. 2022

Drug and Chemical Toxicology

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Ultrastructural changes in rat thyroid tissue after acute organophosphate poisoning and effects of antidotal therapy with atropine and pralidoxime: A single-blind, ex vivo study

Abstract: Acute OP poisoning was associated with histopathologic effects in rat thyroid tissue that appeared to be mitigated by antidotal therapy in this small animal study. More extensive studies using immunohistochemical methods are needed.

Cited by 3 publications

References 7 publications

Effects of acute organophosphate poisoning on pituitary target gland hormones at admission, discharge and three months after poisoning: A hospital based pilot study

Effects of acute organophosphate poisoning on pituitary target gland hormones at admission, discharge and three months after poisoning: A hospital based pilot study

Resíduos de agrotóxicos em alimentos: preocupação ambiental e de saúde para população paraibana

Polyethyleneglycol-serine nanoparticles as a novel antidote for organophosphate poisoning: synthesis, characterization, in vitro and in vivo studies

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