Ultrastructural Basis of the Free-Radical Scavenging Effect of Indapamide in Experimental Myocardial Ischemia and Reperfusion

Mouhieddine, Sahar; Tresallet, N; Boucher, François; Leiris, Joël de

doi:10.1097/00005344-199312050-00009

Cited by 7 publications

(2 citation statements)

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“…Increased intracellular Ca 2 + is responsible for the formation of irreversible damage in the cardiac cell at the end of 15 min global ischemia. [171819]…”

Section: Discussionmentioning

confidence: 99%

Pharmacodynamic interaction of green tea extract with hydrochlorothiazide against ischemia-reperfusion injury-induced myocardial infarction

Chakraborty¹,

Kamath²

2014

J Adv Pharm Technol Res

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Globally, the rate of development of myocardial diseases and hypertension is very common, which is responsible for incremental morbidity and mortality statistics. Treatment of ischemic hypertensive patients with diuretics such as hydrochlorothiazide (HCTZ) can precipitate myocardial infarction due to hypokalemia. This study was undertaken to evaluate the pharmacodynamic interaction of green tea extract (GTE) with HCTZ against ischemia-reperfusion induced myocardial toxicity. Wistar albino rats of either sex were taken and pretreated with high (500 mg/kg, p.o.) and low (100 mg/kg, p.o.) dose of GTE for 30 days. Standard, high and low dose of interactive groups received HCTZ (10 mg/kg, p.o.) for last 7 days. Ischemia-reperfusion injury was induced by modified Lagendorff apparatus, and the effect of different treatments was evaluated by percentage recovery in terms of heart rate and developed tension, serum biomarkers, and heart tissue antioxidant levels. Prophylactic treatment groups, such as high and low dose of GTE and their interactive groups with HCTZ, exhibited significant percentage recovery in terms of heart rate and developed tension. Apart from that, significant increase in superoxide dismutase and catalase, decrease in thiobarbituric acid reactive species in heart tissue, as well as significant decrease in serum lactate dehydrogenase, creatinine phosphokinase-MB and N-acetylcysteine levels have also been documented. The present findings clearly suggest that GTE dose-dependently reduces myocardial toxicity due to ischemia, and combination with HCTZ can reduce the associated side-effects and exhibits myocardial protection.

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“…Increased intracellular Ca 2 + is responsible for the formation of irreversible damage in the cardiac cell at the end of 15 min global ischemia. [171819]…”

Section: Discussionmentioning

confidence: 99%

Pharmacodynamic interaction of green tea extract with hydrochlorothiazide against ischemia-reperfusion injury-induced myocardial infarction

Chakraborty¹,

Kamath²

2014

J Adv Pharm Technol Res

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show abstract

“…Myocardial damage was induced using ischemia reperfusion (IR). The IR was introduced following no flow global ischemia 15 , where sudden occlusion of physiology salt solution results in immediate biochemical alterations.…”

Section: Improvement In Namentioning

confidence: 99%

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2018

IJPSR

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Role of Sida cordifolia L. leaves on biochemical and antioxidant profile during myocardial injury

Kubavat¹,

Asdaq²

2009

Journal of Ethnopharmacology

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Ultrastructural Basis of the Free-Radical Scavenging Effect of Indapamide in Experimental Myocardial Ischemia and Reperfusion

Cited by 7 publications

References 0 publications

Pharmacodynamic interaction of green tea extract with hydrochlorothiazide against ischemia-reperfusion injury-induced myocardial infarction

Pharmacodynamic interaction of green tea extract with hydrochlorothiazide against ischemia-reperfusion injury-induced myocardial infarction

Untitled

Role of Sida cordifolia L. leaves on biochemical and antioxidant profile during myocardial injury

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