Ultrastructural and immunohistochemical characterization of the so‐called giant multinucleate cells in cutaneous collagenomas

Ramos, David; Monteagudo, Carlos; Cardá, Carmen; Ramón, Dolores; González-Devesa, M; Llombart‐Bosch, Antonio

doi:10.1046/j.1365-2559.2002.01438.x

Cited by 13 publications

(11 citation statements)

References 24 publications

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“…Strangely, the lesions were distributed in the submucosa of whole esophagus and intestine. The features of immunohistochemistry were similar to those of eruptive collagenoma reported previously [18]. Masson Trichrome stain confirmed the masses were composed of fibroblastic cells and collagen.…”

Section: Discussionsupporting

confidence: 83%

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Case report: a case of eruptive collagenoma occurring in esophagus and intestine

et al. 2017

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BackgroundEruptive collagenoma is a rare disease. All of the previously reported cases were located on the skin. Here we report such a case occurring in esophagus and intestine.Case presentationOur patient is a Chinese woman. Two years ago, hundreds of small nodules were identified in her esophagus and intestine. The lesions were characterized by thickened hyalinized collagen fibers and haphazard neoplastic stellate cells. The tumor cells showed generally positive for vimentin and negative for h-CALD, CD34, desmin, CD163, AE1/AE3, CK7 and CK20. The nodules were blue with Masson Trichrome stain. The clinicopathological, immunohistochemical and histochemical features of the tumor were consistent with eruptive collagenoma. The patient was not given specific treatment after diagnosis, and a routine examination indicated that there was no progress for 2 years.ConclusionHitherto, this is the first case of eruptive collagenoma to have been reported occurring in esophagus and intestine.

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Section: Discussionsupporting

confidence: 83%

“…Romos et al studied four cutaneous collagenomas using ultrastructural and immunohistochemical analysis. Their findings confirmed that the tumor cells were fibroblastic cells [18]. Collagen deposition was obvious in almost all of the tumors.…”

Section: Discussionmentioning

confidence: 56%

Case report: a case of eruptive collagenoma occurring in esophagus and intestine

et al. 2017

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“…Mutations in several genes necessary for cytokinesis in Dictyostelium also result in multinucleate cells, although these cells can have up to 50 nuclei per cell (Adachi, 2001). It is interesting that several different human tumor types have multinucleate cells (Jayaram and Abdul Rahman, 1997;Long and Aisenberg, 1975;Nonomura et al, 1995;Ramos et al, 2002). AprA thus effectively has two functions: the first to slow the cell cycle and the second to coordinate cytokinesis with mitosis.…”

Section: Discussionmentioning

confidence: 99%

A secreted factor represses cell proliferation inDictyostelium

2005

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Many cells appear to secrete factors called chalones that limit their proliferation, but in most cases the factors have not been identified. We found that growing Dictyostelium cells secrete a 60 kDa protein called AprA for autocrine proliferation repressor. AprA has similarity to putative bacterial proteins of unknown function. Compared with wild-type cells, aprA-null cells proliferate faster, while AprA overexpressing cells proliferate slower. Growing wild-type cells secrete a factor that inhibits the proliferation of wild-type and aprA- cells;this activity is not secreted by aprA- cells. AprA purified by immunoprecipitation also slows the proliferation of wild-type and aprA- cells. Compared with wild type, there is a higher percentage of multinucleate cells in the aprA- population,and when starved, aprA- cells form abnormal structures that contain fewer spores. AprA may thus decrease the number of multinucleate cells and increase spore production. Together, the data suggest that AprA functions as part of a Dictyostelium chalone.

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“…Multinucleated giant cells with a fibroblast-like shape have previously been found in the connective tissue covering teeth delayed in eruption (Onishi et al, 2003;Philipsen et al, 1992;Yonemochi et al, 1998), in the retrocuspid papilla (Buchner et al, 1990), and in cutaneous giant cell collagenomas, where they were notably associated with mast cells (Ramos et al, 2002). The ultrastructural features confirmed that the multinucleated cells of opercula were giant cells.…”

Section: Discussionmentioning

confidence: 52%

Quantitative histological and ultrastructural features of opercula of normally erupting human teeth

Verma¹,

Nair²,

Luder³

2005

Microscopy Res & Technique

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Tooth eruption across the mucosa in humans has been studied rarely, although there are disturbances of eruption that are attributed specifically to failure of the supraosseous eruptive migration. The aim of this study was to analyze the soft tissues covering normally erupting teeth so as to get an insight into the supraosseous phase of tooth eruption and to provide the basis for comparison with cases of eruption disturbances. Six opercula covering normally erupting permanent molars (primary opercula) and six of succedaneous teeth (secondary opercula) were surgically removed from 10 patients aged 7.5-17.5 years. Specimens were examined light and electron microscopically and analyzed morphometrically. All opercula contained strands and islands of odontogenic epithelium, prominent numbers of high endothelial venules, nerves, and mast cells. Nerves comprised normally structured, 1.5-3.5 microm thick myelinated (Adelta) and thinner unmyelinated (C) fibers. In primary opercula, the proportions of blood vessels and nerves were three- and sevenfold higher than the respective values for the secondary opercula. Furthermore, primary opercula contained multinucleated, fibroblast-like giant cells that were not observed in secondary opercula. As all teeth under investigation were erupting normally, neither the presence of the giant cells nor the atypical proportions of blood vessels and nerves appeared to be decisive in the eruption process. These conspicuous tissue components of opercula seem merely to accompany the eruptive tooth movement.

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Ultrastructural and immunohistochemical characterization of the so‐called giant multinucleate cells in cutaneous collagenomas

Abstract: This study supports a distinctive immunohistochemical and overall ultrastructural profile of giant multinucleate cells in giant-cell collagenoma and solitary sclerotic fibroma, which suggests a different pattern of differentiation for these two related cutaneous lesions.

Cited by 13 publications

References 24 publications

Case report: a case of eruptive collagenoma occurring in esophagus and intestine

Case report: a case of eruptive collagenoma occurring in esophagus and intestine

A secreted factor represses cell proliferation inDictyostelium

Quantitative histological and ultrastructural features of opercula of normally erupting human teeth

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