Ultrastructural and biochemical changes of the medial pterygoid muscle induced by unilateral exodontia

Bazan, Emmanuel; Issa, João Paulo Mardegan; Watanabe, Ii-sei; Mandarim-de-Lacerda, Carlos Alberto; Bel, Elaine Aparecida Del; Iyomasa, Mamie Mizusaki

doi:10.1016/j.micron.2007.07.006

Cited by 25 publications

(21 citation statements)

References 32 publications

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“…These characteristics represent morphological reflexes of aggression to muscular cells (Cotran et al, 2000). Alterations in the neuromuscular spindles morphology on this side is in agreement with a study by Bazan et al (2008).…”

Section: Discussionsupporting

confidence: 92%

Morphological and histological effects on the medial pterygoid muscle after unilateral exodontia in gerbils

Iyomasa¹,

Issa²,

Oliveira³

et al. 2008

Micron

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Section: Discussionsupporting

confidence: 92%

Morphological and histological effects on the medial pterygoid muscle after unilateral exodontia in gerbils

Iyomasa¹,

Issa²,

Oliveira³

et al. 2008

Micron

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“…According to Iyomasa et al [21], it was reported that after unilateral molar extraction, the ipsilateral suprahyoid muscle showed atrophic aspects of subsarcolemmal and intermyofibrillar mitochondria. In addition, the same oclusal alteration performed in the present study showed morphological modifications in other structures of the stomatognatic system [22–24]. Then, the unilateral molar teeth exodontia induced different mechanical loading that made both sides of muscle fibers remodeling.…”

Section: Discussionsupporting

confidence: 53%

Histological, Histochemical, and Protein Changes after Induced Malocclusion by Occlusion Alteration of Wistar Rats

Guerra

Pereira

Issa

et al. 2014

BioMed Research International

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Although disorders of the stomatognathic system are common, the mechanisms involved are unknown. Our objective was to study the changes in the masseter muscles after unilateral exodontia. Molar extraction was performed on Wistar rats (left side), and the animals were sacrificed after either 14 or 26 days. The masseter muscle was processed for histological analysis, conventional and in situ zymography, and immunohistochemistry. The morphological analysis showed unique and specific characteristics for the experimental group. By conventional zymography no significant values of 72 kDa MMP-2 (P < 0.05) were found in both of the sides of masseter muscle after 14 and 26 days of unilateral extraction. The in situ zymography showed gelatinolytic activity on all deep masseter muscles, with significant increase on the contralateral side after 14 and 26 days (P < 0.05). The immunohistochemistry demonstrated greater expression of MMP-2 than MMP-9 and MMP-14 in all masseter muscles and there were few differences in the staining of 4 TIMPs. This knowledge about morphology and molecular masticatory muscle remodeling following environmental interventions can be used to develop clinically successful treatments.

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“…Previous studies using experimental animals have shown ultrasctructural alterations in the masseter muscle related to occlusal wear (Bani & Bergamini, 2002;Santiwong et al, 2002) and pterygoid (Bazan et al, 2008;Iyomasa et al, 2008). Some authors as Iyomasa et al and Bani et al have shown that muscle fibers and capillaries are sensitive to different masticatory loads, indicating that this may contribute to understand the way in which the muscles adapt to different loads.…”

Section: Resultsmentioning

confidence: 96%

Influence of Laser Therapy and Muscle Relaxant on the Masseter Muscle under Occlusal Wear: An Ultrastructural Study

et al. 2012

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SUMMARY:The aim of this study was to analyze the influence of low-intensity laser therapy and muscle relaxant in the characteristic ultra structural masseter muscle occlusal wear. Animals and Methods: 40 male Wistar rats were randomly divided into four groups: the control group (GI), occlusal wear (G-II), laser occlusal wear (G-III), and the muscle relaxant occlusal wear (G-IV). Under general anesthesia given intraperitoneally, animals in groups II, III and IV had unilateral amputation of upper and lower molar cusps to simulate an occlusal wear situation. The masseter muscle G-III received laser therapy (830nm, 4J/cm2, 40mW, f ~ 2mm) and the procedure was subsequently repeated every other day for 14/30 days. G-IV animals were treated with daily injection of dantrolene ® (2.5 mg / kg in 0.5 ml of H 2 O). From 24 hours after the elimination peak. The animals were euthanized with an overdose of anesthesia on days 14 and 30 after the removal of the cusps and the ipsilateral masseter muscle was excised and divided in two, one half was routinely processed for light microscopy and other for electron microscopy. There was no statistical difference between each experimental group and the control and between periods in each experimental group. However, the muscle fibers in the G-II showed the most pronounced changes. There is no causal relationship between muscles fibers injuries and occlusion and, despite signs of muscular tissue injury were more evident in the occlusal wear group. Results indicates a moderate action of laser therapy and muscle relaxants in skeletal muscle.

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Ultrastructural and biochemical changes of the medial pterygoid muscle induced by unilateral exodontia

Cited by 25 publications

References 32 publications

Morphological and histological effects on the medial pterygoid muscle after unilateral exodontia in gerbils

Morphological and histological effects on the medial pterygoid muscle after unilateral exodontia in gerbils

Histological, Histochemical, and Protein Changes after Induced Malocclusion by Occlusion Alteration of Wistar Rats

Influence of Laser Therapy and Muscle Relaxant on the Masseter Muscle under Occlusal Wear: An Ultrastructural Study

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