Ultrastructural and Antioxidant Studies of Etoposide Treated Kidney of Rat

Kamble, Pratibha; Kulkarni, Sameer; Dayan,; Bhiwgade, A.

doi:10.4172/1948-5956.1000199

Cited by 6 publications

(5 citation statements)

References 22 publications

(26 reference statements)

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“…Electron dense may be secondary lysosomes which result from engulfing of aggregated proteins or degenerated organelles as mitochondria. This also confirmed by Kamble et al, (2013) [33] who illustrated presence of secondary lysosomes during their study of the effect of etoposide (cancer chemotherapeutic agent) on the rat kidney as an indication of degenerative activity.…”

Section: Discussionsupporting

confidence: 80%

Histological study of the effect of proton pump inhibitor (esomeprazole) on the renal cortex of adult male albino rats.

Salib

Kandeel

El-Mehey

et al. 2019

Egyptian Journal of Histology

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Background: Esomeprazole is one of the proton pump inhibitors used in the treatment of gastrointestinal disorders. In spite of its safety, it can induce many side effects, especially acute interstitial nephritis that may progress into acute renal failure. Aim: This work aimed to investigate the effect of proton pump inhibitor (esomeprazole) on the histological structure of the renal cortex of adult male albino rats, as well as the effect of stoppage of that exposure. Materials and methods: 30 adult male albino rats were divided into three groups (10 rats each); control, esomeprazole group: rats received 5 mg/kg/day esomeprazole orally for 4weeks, and recovery group by which rats received esomeprazole 5 mg/kg /day orally, then left for another 4 weeks without treatment. After that, the renal cortex obtained and processed for light and transmission electron microscopic examination. Results: Esomeprazole group showed shrunken glomeruli with widening of Bowman's space, vacuolated glomerular and tubular cells, with darkly stained nuclei, focal interruption of PAS reaction in the brush border of PCTs besides statistically significant decrease in the mean optical density for PAS when compared with control, and focal ultrastructural changes in renal corpuscles, proximal and distal convoluted tubules. In recovery group; partial improvement of the previous histopathological findings observed. Conclusion: Esomeprazole induced histopathological changes in the structure of the renal cortex of adult male albino rats, which could be partially improved if left to recover.

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Section: Discussionsupporting

confidence: 80%

Histological study of the effect of proton pump inhibitor (esomeprazole) on the renal cortex of adult male albino rats.

Salib

Kandeel

El-Mehey

et al. 2019

Egyptian Journal of Histology

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“…Furthermore, in our histopathological analysis of kidneys we found that ETP administration caused congestion of renal blood vessels, chronic inflammatory cell infiltration (predominantly lymphocytes and fibroblast), marked vacuolar degeneration of renal tubular epithelial cells, and atrophic glomeruli. These observations are in accordance with an earlier study that revealed long-term treatment with ETP resulted in histological alterations in kidneys that are characterized by dilation and enlargement of the proximal convoluted tubules lumen and vacuolar degeneration in their epithelium around nucleus, glomerular atrophy, necrosis, and marked congestion of the glomeruli (Kamble et al, 2013). The possible mechanism of ETP-induced toxicity is suggested to be due to its highly reactive metabolites.…”

Section: Discussionsupporting

confidence: 92%

Histopathological Studies on the Effect of Taurine Against Etoposide-Induced Acute Liver and Kidney Toxicity in Female Albino Rats

Mohammed

Alhassani

2022

UKH J SCI ENG

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Etoposide (ETP) is a topoisomerase Ⅱ (TOP Ⅱ) inhibitor and one of the leading chemotherapeutic drugs for treating a wide variety of tumors. However, ETP induced hepatotoxicity and nephrotoxicity limits its clinical use. This study aims to investigate the protective potential of taurine (Tau) to mitigated histopathological changes in the liver and kidneys of female albino rats treated with ETP. A total of 18 female rats were divided into three groups; control group, ETP-exposed group received intraperitoneal injection of ETP on the first 3 days of the study for a total cumulative dose of 44 mg/kg to induce hepatotoxicity and nephrotoxicity, ETP + Tau group received ETP as stated previously with 400 mg/kg/day of Tau via oral gavage for 15 days. Sections from the liver and kidney were evaluated under light microscope and ETP-exposed group revealed vascular congestion, chronic inflammatory cell infiltration predominantly lymphocytes, edema, vacuolar degeneration, atypical cells, pyknosis, and necrosis while liver and kidney sections of rats treated with combination of ETP + Tau group exhibited marked alleviation of the histopathological damage. The study concludes that treatment with ETP induced marked structural damages in the liver and kidney and such morphological damages are effectively diminished by administering Tau.

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“…Etoposide (ETO) was fabricated by Ebewe Pharma-Egypt and was sold as a colorless solution and stockpiled in the ward or the pharmacy; the injection was reserved in a cool dry place where the temperature stayed below 25 °C and secured from light according to the leaflet. ETO was given as intraperitoneal infusions at 50 mg/kg body weight/twice a week [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

“…The animals that were intramuscularly (im) injected inside the left hip with APAN (30 mg/kg bw/twice a week) for two weeks were categorized in one group (APAN). The mice that were injected intraperitoneally (ip) with ETO for two weeks (50 mg/kg bw/twice a week) [ 22 ] were categorized as one group (ETO). The mice that were injected with both the APAN analog (15 mg/kg bw/im, twice a week) inside the hip and ETO (25 mg/kg bw/ip, twice a week) for two weeks were categorized as one group (APAN+ETO).…”

Section: Methodsmentioning

confidence: 99%

Impact of Synthesized Indoloquinoline Analog to Isolates from Cryptolepis sanguinolenta on Tumor Growth Inhibition and Hepatotoxicity in Ehrlich Solid Tumor-Bearing Female Mice

Nofal

Elmongy

Hassan

et al. 2023

Cells

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The study evaluated the antitumor efficacy of APAN, “synthesized indoloquinoline analog derived from the parent neocryptolepine isolated from the roots of Cryptolepis sanguinolenta”, versus the chemotherapeutic drug etoposide (ETO) in Ehrlich solid tumor (EST)-bearing female mice as well as its protective effect against etoposide-triggered hepatic disorders. APAN showed an ameliorative activity against Ehrlich solid tumor and hepatic toxicity, and the greatest improvement was found in the combined treatment of APAN with ETO. The results indicated that EST altered the levels of tumor markers (AFP, CEA, and anti-dsDNA) and liver biomarker function (ALT, AST, ALP, ALB, and T. protein). Furthermore, EST elevated CD68 and anti-survivin proteins immuno-expressions in the solid tumor and liver tissue. Molecular docking studies were demonstrated to investigate their affinity for both TNF-α and topoisomerase II as target proteins, as etoposide is based on the inhibition of topoisomerase II, and TNF-α is quite highly expressed in the solid tumor and liver tissues of EST-bearing animals, which prompted the authors’ interest to explore APAN affinity to its binding site. Treatment of mice bearing EST with APAN and ETO nearly regularized serum levels of the altered parameters and ameliorated the impact of EST on the tissue structure of the liver better than that by treatment with each of them separately.

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Ultrastructural and Antioxidant Studies of Etoposide Treated Kidney of Rat

Cited by 6 publications

References 22 publications

Histological study of the effect of proton pump inhibitor (esomeprazole) on the renal cortex of adult male albino rats.

Histological study of the effect of proton pump inhibitor (esomeprazole) on the renal cortex of adult male albino rats.

Histopathological Studies on the Effect of Taurine Against Etoposide-Induced Acute Liver and Kidney Toxicity in Female Albino Rats

Impact of Synthesized Indoloquinoline Analog to Isolates from Cryptolepis sanguinolenta on Tumor Growth Inhibition and Hepatotoxicity in Ehrlich Solid Tumor-Bearing Female Mice

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