Ultrastructural Alterations of Alveolar Tissue of Mice

Bils, R. F.; Romanovsky, J. C.

doi:10.1080/00039896.1967.10664851

Cited by 20 publications

(3 citation statements)

References 11 publications

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“…24 Exposure of rats for 3 hr to ambient air containing more than 0.4 ppm oxidant produced changes in the fine structure of the lung with the severity of the damage increasing with age and becoming irreversible at age 21 months. 25 Guinea pigs exposed continuously to ambient air showed a significant increase in flow resistance when the oxidant exceeded 0.5 ppm. 26 An increase in the production of nonmalignant lung tumors was demonstrated in aged mice exposed continuously to ambient air containing an average of 0.02 -0.07 ppm oxidant, 27 …”

Section: Oxidantsmentioning

confidence: 97%

Air Quality Criteria—Toxicological Appraisal for Oxidants, Nitrogen Oxides, and Hydrocarbons

Mueller¹,

Hitchcock²

1969

Journal of the Air Pollution Control Association

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Section: Oxidantsmentioning

confidence: 97%

Air Quality Criteria—Toxicological Appraisal for Oxidants, Nitrogen Oxides, and Hydrocarbons

Mueller¹,

Hitchcock²

1969

Journal of the Air Pollution Control Association

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“…The NIOSH study (18) Bils' 1966 study (20) in which mice of different ages were exposed to ambient Los Angeles air during pollution alerts.…”

Section: Introductionmentioning

confidence: 99%

“…An early example of this approach is Bils' 1967 study (21) in which he exposed mice to synthetic smog produced by reacting propylene, nitric oxide, and carbon monoxide under ultraviolet radiation. A more recent example is the effort at the University of California, Irvine Air Pollution Health Effects Laboratory, involving exposures of animals at rest and during exercise to mixtures generated by reacting various combinations of ozone, sulfur dioxide, nitrogen dioxide, sulfuric acid, ammonium bisulfate, and ferric oxide (22,23).…”

Section: Introductionmentioning

confidence: 99%

Toxicological approaches to complex mixtures.

Mauderly

1993

Environ Health Perspect

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This paper reviews the role of toxicological studies in understanding the health effects of environmental exposures to mixtures. The approach taken is to review mixtures that have received the greatest emphasis from toxicology; major mixtures research programs; the toxicologist's view of mixtures and approaches to their study; and the complementary roles of toxicological, clinical, and epidemiological studies. Studies of tobacco smoke, engine exhaust, combustion products, and air pollutants comprise most of the past research on mixtures. Because of their great experimental control over subjects, exposures, and endpoints, toxicologists tend to consider a wider range of toxic interactions among mixture components and sequential exposures than is practical for human studies. The three fundamental experimental approaches used by toxicologists are integrative (studying the mixture as a whole), dissective (dissecting a mixture to determine causative constituents), and synthetic (studying interactions between agents in simple combinations). Toxicology provides information on potential hazards, mechanisms by which mixture constituents interact to cause effects, and exposure dose-effect relationships; but extrapolation from laboratory data to quantitative human health risks is problematic. Toxicological, clinical, and epidemiological approaches are complementary but are seldom coordinated. Fostering synergistic interactions among the disciplines in studying the risks from mixtures could be advantageous. -Environ Health Perspect 101 (Suppl 4): 155-165 (1993).

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Lung capillary permeability. Nitrogen dioxide exposure and leakage of tritiated serum

Sherwin¹

1971

Archives of Internal Medicine

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Ultrastructural Alterations of Alveolar Tissue of Mice

Cited by 20 publications

References 11 publications

Air Quality Criteria—Toxicological Appraisal for Oxidants, Nitrogen Oxides, and Hydrocarbons

Air Quality Criteria—Toxicological Appraisal for Oxidants, Nitrogen Oxides, and Hydrocarbons

Toxicological approaches to complex mixtures.

Lung capillary permeability. Nitrogen dioxide exposure and leakage of tritiated serum

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