Ultrastrong Freestanding Graphene Oxide Nanomembranes with Surface-Enhanced Raman Scattering Functionality by Solvent-Assisted Single-Component Layer-by-Layer Assembly

Layer-by-layer (LbL) fabricated oxidative multilayers consisting of successive layers of inorganic polyphosphate (PP) and Ce(IV) can electrolessly form thin conducting polymer films on their surface. We describe the effect of substituting every second PP layer in the (PP/Ce) multilayers for graphene oxide (GO) as a means of modifying the structure and mechanical properties of these (GO/Ce/PP/Ce) films and enhancing their growth. Both types of LbL films are based on reversible coordinative bonding between the metal ions and the oxygen-bearing groups in PP and GO, instead of purely electrostatic interactions. The GO incorporation leads to the doubling of the areal mass density and to a dry film thickness close to 300 nm after 4 (GO/Ce/PP/Ce) tetralayers. The film roughness increases significantly with thickness. The (PP/Ce) films are soft materials with approximately equal shear storage and loss moduli, but the incorporation of GO doubles the storage modulus. PP displays a marked terminating layer effect and practically eliminates mechanical losses, making the (GO/Ce/PP/Ce) films almost pure soft elastomers. The smoothness of the (PP/Ce) films and the PP-termination effects are attributed to the reversible coordinative bonding. The (GO/Ce/PP/Ce) films oxidize pyrrole and 3,4-ethylenedioxythiophene (EDOT) and form polypyrrole and PEDOT films on their surfaces. These polymer films are considerably thicker than those formed using the (PP/Ce) multilayers with the same nominal amount of cerium layers. The GO sheets interfere with the polymerization reaction and make its kinetics biphasic. The (GO/Ce) multilayers without PP are brittle and thin.

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“…Cerium probably reduces the interactions between the GO sheets because the LbL films prepared from GO only are robust. 79 …”

Section: Resultsmentioning

confidence: 99%

Oxidative Layer-By-Layer Multilayers Based on Metal Coordination: Influence of Intervening Graphene Oxide Layers

et al. 2018

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“…Thus, fabrication in the liquid form can also be found in previous literature. Some materials (e.g., organic materials) can form a nanomembrane structure simply by normal spin‐coating process or layer‐by‐layer assembly process . But in most cases, chemical reactions must be involved to synthesize the materials needed.…”

Section: Perspective Of Nanomembrane Technologymentioning

confidence: 99%

“…Some materials (e.g., organic materials) can form a nanomembrane structure simply by normal spin-coating process [64,65] or layer-by-layer assembly process. [66][67][68][69] But in most cases, chemical reactions must be involved to synthesize the materials needed. One can find the nanomembranes fabricated by sol-gel method, [70,71] hydrothermal/solvothermal synthesis, [72] etc.…”

Section: Flexible Electronicsmentioning

confidence: 99%

Assembly and Self‐Assembly of Nanomembrane Materials—From 2D to 3D

Huang

Mei

2018

Small

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Nanoscience and nanotechnology offer great opportunities and challenges in both fundamental research and practical applications, which require precise control of building blocks with micro/nanoscale resolution in both individual and mass-production ways. The recent and intensive nanotechnology development gives birth to a new focus on nanomembrane materials, which are defined as structures with thickness limited to about one to several hundred nanometers and with much larger (typically at least two orders of magnitude larger, or even macroscopic scale) lateral dimensions. Nanomembranes can be readily processed in an accurate manner and integrated into functional devices and systems. In this Review, a nanotechnology perspective of nanomembranes is provided, with examples of science and applications in semiconductor, metal, insulator, polymer, and composite materials. Assisted assembly of nanomembranes leads to wrinkled/buckled geometries for flexible electronics and stacked structures for applications in photonics and thermoelectrics. Inspired by kirigami/origami, self-assembled 3D structures are constructed via strain engineering. Many advanced materials have begun to be explored in the format of nanomembranes and extend to biomimetic and 2D materials for various applications. Nanomembranes, as a new type of nanomaterials, allow nanotechnology in a controllable and precise way for practical applications and promise great potential for future nanorelated products.

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“…Herein, we report a nanogap‐rich Au nanowire (NW) SERS sensor for ultrasensitive and specific detection of telomerase activity in cancer cells and tissues. SERS is a phenomenon in which the Raman signals of molecules are strongly increased at the nanogaps between adjacent plasmonic nanostructures . We fabricated the nanogap‐rich Au NW SERS sensors by simply depositing nanoparticles (NPs) on Au NWs.…”

Section: Introductionmentioning

confidence: 99%

Nanogap‐Rich Au Nanowire SERS Sensor for Ultrasensitive Telomerase Activity Detection: Application to Gastric and Breast Cancer Tissues Diagnosis

Eom

Kim

Hwang

et al. 2017

Adv Funct Materials

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Telomerase has attracted much attention as a universal cancer biomarker because telomerase is overexpressed in more than 85% of human cancer cells while suppressed in normal somatic cells. Since a strong association exists between telomerase activity and human cancers, the development of effective telomerase activity assay is critically important. Here, a nanogaprich Au nanowire (NW) surface-enhanced Raman scattering (SERS) sensor is reported for detection of telomerase activity in various cancer cells and tissues. The nanogap-rich Au NWs are constructed by deposition of nanoparticles on single-crystalline Au NWs and provided highly reproducible SERS spectra. The telomeric substrate (TS) primer-attached nanogap-rich Au NWs can detect telomerase activity through SERS measurement after the elongation of TS primers, folding into G-quadruplex structures, and intercalation of methylene blue. This sensor enables us to detect telomerase activity from various cancer cell lines with a detection limit of 0.2 cancer cells mL −1 . Importantly, the nanogap-rich Au NW sensor can diagnose gastric and breast cancer tissues accurately. The nanogap-rich Au NW sensors show strong SERS signals only in the presence of tumor tissues excised from 16 tumorbearing mice, while negligible signals in the presence of heated tumor tissues or normal tissues. It is anticipated that nanogap-rich Au NW SERS sensors can be used for a universal cancer diagnosis and further biomedical applications including a diverse biomarker sensing.

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Ultrastrong Freestanding Graphene Oxide Nanomembranes with Surface-Enhanced Raman Scattering Functionality by Solvent-Assisted Single-Component Layer-by-Layer Assembly

Cited by 49 publications

References 74 publications

Oxidative Layer-By-Layer Multilayers Based on Metal Coordination: Influence of Intervening Graphene Oxide Layers

Oxidative Layer-By-Layer Multilayers Based on Metal Coordination: Influence of Intervening Graphene Oxide Layers

Assembly and Self‐Assembly of Nanomembrane Materials—From 2D to 3D

Nanogap‐Rich Au Nanowire SERS Sensor for Ultrasensitive Telomerase Activity Detection: Application to Gastric and Breast Cancer Tissues Diagnosis

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