Ultrasound use in metastatic breast cancer to measure body composition changes following an exercise intervention

Escriche-Escuder, Adrián; Trinidad-Fernández, Manuel; Pajares, Bella; Iglesias‐Campos, Marcos; Alba, Emilio; Cuesta-Vargas, Antonio; Roldán-Jiménez, Cristina

doi:10.1038/s41598-021-88375-5

Cited by 6 publications

(14 citation statements)

References 67 publications

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“…Concerning the regression model, Q Muscle Non-Conn Energy and the Q Muscle Non-Contraction Textural Correlation, after adjusting by age and weight, explained 90% of QLQ-BR23 variance (R 2 = 0.90, P < 0.01). A previous study in this population found that an architecture US outcome from BB muscle after adjusting by age and weight explained 70% of QLQ-BR 23 variance 26 . Comparing both results shows that muscular echotexture from Q muscle explains better QoL in MBC patients than muscular architecture from BB.…”

Section: Discussionmentioning

confidence: 72%

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Responsiveness of the new index muscular echotexture in women with metastatic breast cancer: an exercise intervention study

Escriche-Escuder

Trinidad-Fernández

Pajares

et al. 2022

Sci Rep

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Ultrasound imaging texture analyses may provide information on tissue homogeneity changes in metastatic breast cancer (MBC) through second-order analyzes based on the gray-level co-occurrence matrix. This study aimed to analyze the responsiveness and correlations of biomarkers of muscular and fat echotexture after an exercise intervention in women with MBC. A 12-week exercise intervention was conducted in 2019, including aerobic and strength training. Echotexture variables were obtained at baseline and after intervention from the quadriceps (Q) and biceps brachii and brachialis. Mean differences were calculated using the T-Student parametric test for dependent samples of the differences in the means (P = 0.05; 95% CI). Data obtained from 13 MBC women showed significant differences in some echotexture variables after the intervention. QLQ-BR23 questionnaire correlated with several echotexture variables from muscle and subcutaneous fat. PFS-R scale correlated positively with the Q Subcutaneous Fat Non-Contraction Homogeneity (R = 0.43, P < 0.05). Q Muscle Non-Contraction Energy and Q Muscle Non-Contraction Textural Correlation explained 90% of the variance of QLQ-BR23. Some muscle and subcutaneous fat echotexture biomarkers showed good responsiveness after the exercise intervention. Additionally, some muscle and subcutaneous fat variables correlated with QLQ-BR23 and cancer-related fatigue measured by PFS-R scale in MBC patients.Trial registration: NCT03879096

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Section: Discussionmentioning

confidence: 72%

“…Imaging techniques have proven to be useful for analysing sarcopenia and body composition 25 . Specifically, ultrasound imaging (US) tools are commonly used in clinical practice to offer reliable information about tissue architecture and composition through an affordable and non-invasive method 26 – 28 .…”

Section: Introductionmentioning

confidence: 99%

Responsiveness of the new index muscular echotexture in women with metastatic breast cancer: an exercise intervention study

Escriche-Escuder

Trinidad-Fernández

Pajares

et al. 2022

Sci Rep

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“…Cross‐sectional area of rectus femoris (RF) and muscle thickness of the quadriceps [combining RF and vastus intermedius (VI) thickness] were the most frequently measured metrics used to correlate against a clinical or functional outcome measure. Of the 10 studies that investigated echointensity of quadriceps (indicating muscle quality/fat content), 7 found statistically significant correlations with clinical and functional outcomes 23,26,32,33,36,43,45,47,51,55 . Twenty studies took serial measurements of the same muscle group to describe longitudinal changes in muscle mass.…”

Section: Resultsmentioning

confidence: 99%

“…Other groups included biceps brachii, tibialis anterior, flexor carpi radialis, and psoas. Four of the studies included both upper and lower limb measurements 33,43,45,56 . The most frequently adopted anatomical landmarks were the midpoint of the thigh between anterior superior iliac spine and the superior border of patella (38%), the distal point measured at 2/3rd distance (24%), or both (16%).…”

Section: Resultsmentioning

confidence: 99%

“…The number of publications over the last 18 months ( n = 18 studies) was similar to that of the preceding 11 years ( n = 19 studies) highlighting the recent surge of new evidence ( Figure 2 ). Data from 26 prospective observational studies 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 (of which 6 were cohort studies, 44 , 45 , 46 , 47 , 48 , 49 7 cross‐sectional studies, 27 , 50 , 51 , 52 , 53 , 54 , 55 3 randomized control trials, 56 , 57 , 58 and 1 post hoc analysis of a negative trial) were included. 59 Five of the 37 studies involved an interventional arm [critical care nutritional intervention ( n = 4) 44 , 56 , 57 , 58 and an exercise intervention in breast cancer ( n = 1) 45 ].…”

Section: Resultsmentioning

confidence: 99%

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The current use of ultrasound to measure skeletal muscle and its ability to predict clinical outcomes: a systematic review

Casey

Alasmar

McLaughlin

et al. 2022

J cachexia sarcopenia muscle

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Quantification and monitoring of lean body mass is an important component of nutrition assessment to determine nutrition status and muscle loss. The negative impact of reduced muscle mass and muscle function is increasingly evident across acute and chronic disease states but is particularly pronounced in patients with cancer. Ultrasound is emerging as a promising tool to directly measure skeletal muscle mass and quality. Unlike other ionizing imaging techniques, ultrasound can be used repeatedly at the bedside and may compliment nutritional risk assessment. This review aims to describe the current use of skeletal muscle ultrasound (SMUS) to measure muscle mass and quality in patients with acute and chronic clinical conditions and its ability to predict functional capacity, severity of malnutrition, hospital admission, and survival. Databases were searched from their inception to August 2021 for full-text articles in English. Relevant articles were included if SMUS was investigated in acute or chronic clinical contexts and correlated with a defined clinical outcome measure. Data were synthesized for narrative review due to heterogeneity between studies. This review analysed 37 studies (3100 patients), which met the inclusion criteria. Most studies (n = 22) were conducted in critical care. The clinical outcomes investigated included functional status at discharge (intensive care unit-acquired weakness), nutritional status, and length of stay. SMUS was also utilized in chronic conditions such as chronic obstructive pulmonary disease, chronic heart failure, and chronic renal failure to predict hospital readmission and disease severity. Only two studies investigated the use of SMUS in patients with cancer. Of the 37 studies, 28 (76%) found that SMUS (crosssectional area, muscle thickness, and echointensity) showed significant associations with functional capacity, length of stay, readmission, and survival. There was significant heterogeneity in terms of ultrasound technique and outcome measurement across the included studies. This review highlights that SMUS continues to gain momentum as a potential tool for skeletal muscle assessment and predicting clinically important outcomes. Further work is required to standardize the technique in nutritionally vulnerable patients, such as those with cancer, before SMUS can be widely adopted as a bedside prognostic tool.

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Skeletal Muscle Mass, Strength, and Physical Performance Gains Are Similar Between Healthy Postmenopausal Women and Postmenopausal Breast Cancer Survivors After 12 Weeks of Resistance Exercise Training

Artigas,

Alegría-Molina,

Vidal-Seguel

et al. 2024

Preprint

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Background: Resistance exercise training (RET) has been shown to be effective in increasing skeletal muscle mass and strength in healthy postmenopausal women. In postmenopausal breast cancer survivors, however, the effects of RET on these parameters are reported as either controversial or limited. Aim: To compare the effects of a 12-week progressive whole-body RET program, on skeletal muscle mass, muscle strength and physical performance in healthy postmenopausal women versus postmenopausal women who are breast cancer survivors. Methods: Healthy (HEA, 54±3 years, BMI 26.6±2.7 kg·m2, n=13) and breast cancer survivors (BCS, 52±5 years, BMI 26.8±2.1 kg·m2, n=11) postmenopausal women were subjected to 12 weeks of progressive whole-body RET, three times per week. quadriceps muscle thickness ultrasound; one-repetition maximum (1RM) of leg extension, leg press, chest press, horizontal row, and elbow extension; grip strength and physical performance (6-minute walk test, dynamic balance test, and chair stand-up test) were assessed before and after the RET program. Results: Quadriceps muscle thickness increased from 3.6±0.6 to 3.9±0.7 cm2 (5±7%) and from 3.5±0.50 to 3.7±0.5 cm2 (7±4%), in HEA and BCS, respectively (Time, P<0.001; η2=0.44) without differences between groups. 1RM leg extension strength increased from 57±10 to 80±15 kg (41±12%) and from 54±13 to 77±18 kg (43±16 %) (Time, P<0.001; η2=0.88) in the HEA and BCS groups, respectively. Similar improvements were observed for 1RM leg press, 1RM chest press, 1RM horizontal row, and 1RM elbow extension (Time effect: all P<0.001; η2≥0.85), and grip strength (Time effect: P=0.035; η2=0.19) in the HEA and BCS groups. No differences in responses to RET were observed between groups (Time×Group, all P>0.185; all η2 ≤0.09) for all strength outcomes. Physical performance showed significant improvement (all P<0.001; η2 ≥0.45), with no differences between groups (Time×Group, P≥0.05; η2≤0.05). Conclusion: Twelve weeks of RET significantly increase skeletal muscle mass, strength, and physical performance in postmenopausal women. No differences were observed between healthy postmenopausal women and postmenopausal breast cancer survivors. These findings point out that this study's RET promotes marked skeletal muscle mass, strength, and performance gains regardless of breast cancer. Trial registration: This trial is registered on ClinicalTrials.gov: NCT05690295 as of December 22, 2022

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Ultrasound use in metastatic breast cancer to measure body composition changes following an exercise intervention

Cited by 6 publications

References 67 publications

Responsiveness of the new index muscular echotexture in women with metastatic breast cancer: an exercise intervention study

Responsiveness of the new index muscular echotexture in women with metastatic breast cancer: an exercise intervention study

The current use of ultrasound to measure skeletal muscle and its ability to predict clinical outcomes: a systematic review

Skeletal Muscle Mass, Strength, and Physical Performance Gains Are Similar Between Healthy Postmenopausal Women and Postmenopausal Breast Cancer Survivors After 12 Weeks of Resistance Exercise Training

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