Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules

Jin, Di; Yu, Jicheng; Wang, Qun; Yao, Shanshan; Suo, Dingjie; Ye, Yanqi; Pless, Matthew; Zhu, Yong; Jing, Yun; Gu, Zhen

doi:10.1007/s12274-017-1500-z

Cited by 72 publications

(54 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, in vivo investigations have shown that these materials can be used as osteoconductive bone fillers with in vivo drug release ability . Although the assembly of biomaterials from colloidal particles was shown to be a promising strategy for the development of injectable and self‐healing gels with tissue regenerative[8a,b,9b,c,20] and drug release[9a,21,22] capabilities, the potential of colloidal gel systems for regeneration of osteoporotic bone defects has never been explored before. Hence, the goal of this study was to develop injectable and self‐healing composite colloidal gels that combine mechanical robustness with the capacity to regenerate osteoporotic bone through the concerted action of anabolic and anticatabolic stimuli.…”

Section: Discussionmentioning

confidence: 99%

Composite Colloidal Gels Made of Bisphosphonate‐Functionalized Gelatin and Bioactive Glass Particles for Regeneration of Osteoporotic Bone Defects

Diba

Camargo

Brindisi

et al. 2017

Adv Funct Materials

View full text Add to dashboard Cite

Injectable composite colloidal gels are developed for regeneration of osteoporotic bone defects through a bottom-up assembly from bisphosphonatefunctionalized gelatin and bioactive glass particles. Upon bisphosphonate functionalization, gelatin nanoparticles show superior adhesion toward bioactive glass particles, resulting in elastic composite gels. By tuning their composition, these composite colloidal gels combine mechanical robustness with self-healing ability. The composite colloidal gels support cell proliferation and differentiation in vitro without requiring any osteogenic supplement. In vivo evaluation of the composite colloidal gels reveals their capacity to support the regeneration of osteoporotic bone defects. Furthermore, the bisphosphonate modification of gelatin induces a therapeutic effect on the peri-implantation region by enhancing the bone density of the osteoporotic bone tissue. Consequently, these composite colloidal gels offer new therapeutic opportunities for treatment of osteoporotic bone defects.

show abstract

Section: Discussionmentioning

confidence: 99%

Composite Colloidal Gels Made of Bisphosphonate‐Functionalized Gelatin and Bioactive Glass Particles for Regeneration of Osteoporotic Bone Defects

Diba

Camargo

Brindisi

et al. 2017

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…In a very recent study, Di et al developed an ultrasound-triggered insulin-delivery system which allows for pulsatile insulin release that can provide both long-term, sustained and fast on-demand responses. 103 This system incorporated insulin-loaded PLGA nanocapsules encapsulated within chitosan microgels and, upon ultrasound treatment, the stored insulin can be rapidly released to regulate blood glucose levels. 103 The research group found that in a mouse model of type 1 diabetes, a 30-second ultrasound administration could effectively achieve glycemic control for 1 week and concluded that this delivery system may potentially be used to release other therapeutics in a noninvasive and convenient manner.…”

Section: Natural Biodegradable Polymeric Biomaterialsmentioning

confidence: 99%

Current development of biodegradable polymeric materials for biomedical applications

Song

Murphy

et al. 2018

DDDT

684

358

View full text Add to dashboard Cite

In the last half-century, the development of biodegradable polymeric materials for biomedical applications has advanced significantly. Biodegradable polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering. Further advancements have occurred in the utilization of biodegradable polymeric materials for pharmacological applications such as delivery vehicles for controlled/sustained drug release. These applications require particular physicochemical, biological, and degradation properties of the materials to deliver effective therapy. As a result, a wide range of natural or synthetic polymers able to undergo hydrolytic or enzymatic degradation is being studied for biomedical applications. This review outlines the current development of biodegradable natural and synthetic polymeric materials for various biomedical applications, including tissue engineering, temporary implants, wound healing, and drug delivery.

show abstract

“…In addition to the use of relatively slow acid‐labile chemistries, a variety of hypoxia‐ and peroxide‐sensitive chemistries have been used, which are faster and also integrate with outputs from GOx activity (Figure B) . A closely related strategy was shown using ultrasound‐triggered release of insulin from chitosan microgels, which can be coupled to CGM sensors so as to enable an ultrasound stimulus to be provided when needed …”

Section: Glucose Sensing By Engineering With Proteinsmentioning

confidence: 99%

Biologically Inspired and Chemically Derived Methods for Glucose‐Responsive Insulin Therapy

VandenBerg

Webber

2019

Adv Healthcare Materials

View full text Add to dashboard Cite

The controlled delivery of therapeutics in a manner responsive to physiological indicators has promise in realizing new therapeutic approaches to combat disease. This approach is especially relevant in the context of diabetes. Natural fluctuations in blood glucose seen in the healthy state, complete with peaks and troughs, are poorly regulated as a result of detrimental production or ineffective signaling of the insulin hormone. While several manifestations of diabetes are treated with regularly administered exogenous insulin, the present standard of care results in suboptimal glycemic management that poorly recreates natural hormone control, leading to long‐term instability and a significantly increased risk for secondary health complications. New synthetic technologies that make insulin available only when needed, and at the exact dose required, have been explored under the broad vision of realizing a “fully synthetic pancreas.” Yet, many challenges remain to realizing a technology that is appropriately responsive, safe, and well integrated into a manageable routine. Herein, many of the approaches explored thus far to sense physiological blood glucose and elicit response through the release of therapeutic insulin are summarized. The approaches point to a new, autonomous approach to managing diabetes with biomimetic therapy.

show abstract

Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules

Cited by 72 publications

References 32 publications

Composite Colloidal Gels Made of Bisphosphonate‐Functionalized Gelatin and Bioactive Glass Particles for Regeneration of Osteoporotic Bone Defects

Composite Colloidal Gels Made of Bisphosphonate‐Functionalized Gelatin and Bioactive Glass Particles for Regeneration of Osteoporotic Bone Defects

Current development of biodegradable polymeric materials for biomedical applications

Biologically Inspired and Chemically Derived Methods for Glucose‐Responsive Insulin Therapy

Contact Info

Product

Resources

About