Ultrasound-triggered in situ gelation with ROS-controlled drug release for cartilage repair

Abstract

Cartilage defects are usually caused by acute trauma and chronic degeneration. However, it is still a great challenge to improve the repair of articular cartilage defects due to the limited...

Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor

“…5 A depicted experimental animals were randomly allocated to four different groups: Sham group (serving as the positive control), Control group (untreated experimental group), RSD-MS group (group treated solely with RSD-MSs), and COP group (group treated with COPs). Throughout the experimental procedure, at postoperative weeks 5 and 10, rats underwent euthanasia, following which tissue specimens from the femur, heart, liver, kidney, lung, and spleen were harvested for subsequent laboratory analyses [ 33 ].

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Dual-network DNA–silk fibroin hydrogels with controllable surface rigidity for regulating chondrogenic differentiation

“…The analysis results were consistent with our previous findings, indicating that the dual-network DNA–SF hydrogel upregulated the mTOR pathway to promote chondrogenic differentiation of BMSCs. 41 It is worth noting that the DNA–SF hydrogel upregulated ECM receptor interactions and multiple chondrogenic related signaling pathways. As shown in Fig.…”

3D Printed Conductive Hydrogel Patch Incorporated with MSC@GO for Efficient Myocardial Infarction Repair

“…Fibrinogen is the natural biological polymer that acts as a scaffold for tissue regeneration and promotes cell migration, as well as the good biocompatibility. − Fibrin hydrogel formed by the mixture of fibrinogen and thrombin is known as a cell adhesive extracellular matrix, which has been widely applied in regenerative medicine. − Nakamura et al successfully printed living cells mixed in fibrin hydrogels to form active hydrogel sheets. They also observed that cells in fibrin hydrogel adhered, expanded, and proliferated during incubation .…”