Ultrasound Triggered Drug Release from Affinity-Based β-Cyclodextrin Polymers for Infection Control

Bohara, Smriti; Rohner, Nathan A.; Budziszewski, Emily; Suthakorn, Jackrit; Recum, Horst A. von; Exner, Agata A.

doi:10.1007/s10439-021-02814-y

Cited by 2 publications

(1 citation statement)

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“…Hydrogels have both hydrophobic and hydrophilic character and are biocompatible which can be refilled without revision surgery over time. These types of hydrogels give sustained drug delivery over time and control surgical site infection related to implants [ 121 – 123 ]. They are widely used for implant coatings as a measure to reduce infections related to implants and for prevention of implant failure.…”

Section: Introductionmentioning

confidence: 99%

Surface coating of orthopedic implant to enhance the osseointegration and reduction of bacterial colonization: a review

Bohara

Suthakorn

2022

Biomater Res

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The use of orthopedic implants in surgical technology has fostered restoration of physiological functions. Along with successful treatment, orthopedic implants suffer from various complications and fail to offer functions correspondent to native physiology. The major problems include aseptic and septic loosening due to bone nonunion and implant site infection due to bacterial colonization. Crucial advances in material selection in the design and development of coating matrixes an opportunity for the prevention of implant failure. However, many coating materials are limited in in-vitro testing and few of them thrive in clinical tests. The rate of implant failure has surged with the increasing rates of revision surgery creating physical and sensitive discomfort as well as economic burdens. To overcome critical pathogenic activities several systematic coating techniques have been developed offering excellent results that combat infection and enhance bone integration. This review article includes some more common implant coating matrixes with excellent in vitro and in vivo results focusing on infection rates, causes, complications, coating materials, host immune responses and significant research gaps. This study provides a comprehensive overview of potential coating technology, with functional combination coatings which are focused on ultimate clinical practice with substantial improvement on in-vivo tests. This includes the development of rapidly growing hydrogel coating techniques with the potential to generate several accurate and precise coating procedures.

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Section: Introductionmentioning

confidence: 99%