Ultrasound‐trigged micro/nanorobots for biomedical applications

Huang, Dongzhou; Cai, Lijun; Li, Ning; Zhao, Yuanjin

doi:10.1002/smmd.20230003

Cited by 4 publications

(2 citation statements)

References 111 publications

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“…Pharmaceutics 2024, 16, x FOR PEER REVIEW 7 of 25 being widely used for nano/micromotor propulsion [67][68][69]. Both surface acoustic waves (SAWs) and ultrasonic standing waves (USWs) can be used for nano/micromotor manipulation.…”

Section: Ultrasound Waves For Propulsionmentioning

confidence: 99%

“…By using ultrasound as the energy input, nano/micromotors can avoid using toxic fuel and, thus, be highly biocompatible. Ultrasound is also currently being widely used for nano/micromotor propulsion [ 67 , 68 , 69 ]. Both surface acoustic waves (SAWs) and ultrasonic standing waves (USWs) can be used for nano/micromotor manipulation.…”

Section: Ultrasound Waves For Propulsionmentioning

confidence: 99%

See 1 more Smart Citation

Nano/Micromotors for Cancer Diagnosis and Therapy: Innovative Designs to Improve Biocompatibility

Zheng,

Huang,

Lin

et al. 2023

Pharmaceutics

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Nano/micromotors are artificial robots at the nano/microscale that are capable of transforming energy into mechanical movement. In cancer diagnosis or therapy, such “tiny robots” show great promise for targeted drug delivery, cell removal/killing, and even related biomarker sensing. Yet biocompatibility is still the most critical challenge that restricts such techniques from transitioning from the laboratory to clinical applications. In this review, we emphasize the biocompatibility aspect of nano/micromotors to show the great efforts made by researchers to promote their clinical application, mainly including non-toxic fuel propulsion (inorganic catalysts, enzyme, etc.), bio-hybrid designs, ultrasound propulsion, light-triggered propulsion, magnetic propulsion, dual propulsion, and, in particular, the cooperative swarm-based strategy for increasing therapeutic effects. Future challenges in translating nano/micromotors into real applications and the potential directions for increasing biocompatibility are also described.

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Section: Ultrasound Waves For Propulsionmentioning

confidence: 99%

Section: Ultrasound Waves For Propulsionmentioning

confidence: 99%

Nano/Micromotors for Cancer Diagnosis and Therapy: Innovative Designs to Improve Biocompatibility

Zheng,

Huang,

Lin

et al. 2023

Pharmaceutics

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Design Approaches and Electromechanical Modeling of Conformable Piezoelectric‐Based Ultrasound Systems

Amiri,

Shah,

Bhayadia

et al. 2024

Advanced Sensor Research

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Painless, needleless delivery of drugs through the skin can be realized through aphenomenon called sonophoresis by applying an ultrasound field to the biological tissue. Development of wearable embodiments of such systems demands comprehensive characterization of both the physical mechanism of sonophoresisas well as wearability parameters. Here, we present a framework for analyzing disk‐type piezoelectric transducers in a polymeric substrate to create acoustic cavitation in a fluid coupling medium for sonophoresis applications. The device design and operating parameters such as the working frequency, applied voltage range, acoustic pressure distribution, and transducer spacing were determine dusing a finite element methods (FEM),and verified with experimental measurements. The influence of the surrounding water and tank reflections on the acoustic pressure field, and the interaction between the elements in the array structure were also studied.Finally, the impact of skin and the substrate geometry on the acoustic pressure fields was characterized to simulate the invivo use‐case of the system. These analytical models can be used to guide critical parameters for device design such as the separation distance of the piezoelectric transducer from the skin boundary. We envision that this tool boxwill support rapid design iteration for realization of wearable ultrasound systems.

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Acoustically Actuated Flow in Microrobots Powered by Axisymmetric Resonant Bubbles

Mohanty,

Lin,

Paul

et al. 2023

Advanced Intelligent Systems

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Bubble‐driven microsystems inspired by the therapeutic use of microbubbles under clinical ultrasound actuation offer innovative remote manipulation in biological settings. Ultrasound‐powered microrobots, benefiting from a distribution of vibrating microbubbles (1–100 μm in diameters), exhibit localized fluid flow for self‐propulsion. Microbubbles also contribute to the design of acoustic metamaterials, where distributed actuation of bubbles enables exotic material properties (e.g., negative refractive index). Herein, a metamaterial‐inspired microrobot design, which exploits the streaming induced by the collective oscillation of microbubble arrays (> 10), is reported. Such a large distribution of bubbles offers twofold advantages: a mesoscale microrobot allowing ease of handling and motion at a considerably low acoustic driving pressure of 50 kPa. In this work, the oscillatory amplitude of a single bubble that acts as a unit cell of the metamaterial‐based microrobot is first characterized. Thereon, this amplitude is related to the flow generated by the collective vibration of all the bubbles close to the theoretically predicted resonant frequency of the bubbles. Finally, the hovering motion of the microrobot induced by the streaming and flow‐assisted debris clearance is demonstrated. Such auxiliary functionalities of the microrobot can be useful for applications like contactless sample extraction in inaccessible biological environments.

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Ultrasound‐trigged micro/nanorobots for biomedical applications

Cited by 4 publications

References 111 publications

Nano/Micromotors for Cancer Diagnosis and Therapy: Innovative Designs to Improve Biocompatibility

Nano/Micromotors for Cancer Diagnosis and Therapy: Innovative Designs to Improve Biocompatibility

Design Approaches and Electromechanical Modeling of Conformable Piezoelectric‐Based Ultrasound Systems

Acoustically Actuated Flow in Microrobots Powered by Axisymmetric Resonant Bubbles

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