Ultrasound Thermotherapy of Breast: Theoretical Design of Transducer and Numerical Simulation of Procedure

Behnia, S.; Ghalichi, Farzan; Bonabi, A.; Jafari, Amin

doi:10.1143/jjap.45.1856

Cited by 7 publications

(4 citation statements)

References 68 publications

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“…The BioHeat equation can be solved with initial and boundary conditions by numerical methods. These methods include the Finite Element Method (FEM) (Das et al, 1999), the Finite Difference Time Domain (FDTD) method (Curra et al, 2000) and solution by a semi-discrete scheme of Galerkian FEM (Sohrab et al, 2006). These simulated results were found to be in a good agreement with ex vivo and in vivo experimental observations (Chapelon et al, 1993).…”

Section: Introductionmentioning

confidence: 67%

Fast algorithm in estimating high intensity focused ultrasound induced lesions

Zhou

2010

IJCBDD

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High Intensity Focused Ultrasound (HIFU) has been emerging as a new and effective modality in non-invasive thermal ablation for cancers and solid tumours. Although a theoretical model is available for calculating thermal field and the consequent lesion production, its computation is too time-consuming (~ 1 day) for HIFU treatment planning on the site. In this study, several approximations were made on the BioHeat equation to estimate HIFU-induced lesions. Experimental results, estimation and theoretical calculation were compared with each other in a good agreement. However, the computation time for 25 treatment spots was only 1 min. Altogether, the developed fast algorithm provides an accurate outcome in a timely fashion and can push the wide acceptance of HIFU technology in clinics.

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Section: Introductionmentioning

confidence: 67%

Fast algorithm in estimating high intensity focused ultrasound induced lesions

Zhou

2010

IJCBDD

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“…The density of breast tissue and the specific heat capacity and thermal conductivity of tumour tissue can be traced back to Sohrab et al [ 79 ]. These values were cited from a Ph.D. thesis not available digitally.…”

Section: Resultsmentioning

confidence: 99%

Review of Thermal and Physiological Properties of Human Breast Tissue

Camilleri

Farrugia

Curto

et al. 2022

Sensors

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Electromagnetic thermal therapies for cancer treatment, such as microwave hyperthermia, aim to heat up a targeted tumour site to temperatures within 40 and 44 °C. Computational simulations used to investigate such heating systems employ the Pennes’ bioheat equation to model the heat exchange within the tissue, which accounts for several tissue properties: density, specific heat capacity, thermal conductivity, metabolic heat generation rate, and blood perfusion rate. We present a review of these thermal and physiological properties relevant for hyperthermia treatments of breast including fibroglandular breast, fatty breast, and breast tumours. The data included in this review were obtained from both experimental measurement studies and estimated properties of human breast tissues. The latter were used in computational studies of breast thermal treatments. The measurement methods, where available, are discussed together with the estimations and approximations considered for values where measurements were unavailable. The review concludes that measurement data for the thermal and physiological properties of breast and tumour tissue are limited. Fibroglandular and fatty breast tissue properties are often approximated from those of generic muscle or fat tissue. Tumour tissue properties are mostly obtained from approximating equations or assumed to be the same as those of glandular tissue. We also present a set of reliable data, which can be used for more accurate modelling and simulation studies to better treat breast cancer using thermal therapies.

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“…Two heterogeneous 3D models of the breast anatomy are constructed. A segmentation toolbox (iSeg, Schmid & Partner Engineering AG, Switzerland) is used to delineate the Hounsfield units (CT) or grey values (MRI) into various tissues with corresponding acoustic (Sohrab et al 2006) and thermal properties, which are listed in table 1.…”

Section: Heterogeneous Breast Modelsmentioning

confidence: 99%

An ultrasound cylindrical phased array for deep heating in the breast: theoretical design using heterogeneous models

et al. 2009

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The objective of this theoretical study is to design an ultrasound (US) cylindrical phased array that can be used for hyperthermia (40-44 degrees C) treatment of tumours in the intact breast. Simultaneously, we characterize the influence of acoustic and thermal heterogeneities on the specific absorption rate (SAR) and temperature patterns to determine the necessity of using heterogeneous models for a US applicator design and treatment planning. Cylindrical configurations of monopole transducers are studied on their ability to generate interference patterns that can be steered electronically to the location of the target region. Hereto, design parameters such as frequency, number of transducers per ring, ring distance and number of rings are optimized to obtain a small primary focus, while suppressing secondary foci. The models account for local heterogeneities in both acoustic (wave velocity and absorption) and thermal (blood perfusion rate, heat capacity and conductivity) tissue properties. We used breast models with a central tumour (30x20x38 mm3) and an artificial thorax tumour (sphere with a radius of 25 mm) to test the design. Simulations predict that a US cylindrical phased array, consisting of six rings with 32 transducers per ring, a radius of 75 mm and 66 mm distance between the first and sixth transducer ring, operating at a frequency of 100 kHz, can be used to obtain 44 degrees C in the centre of tumours located anywhere in the intact breast. The dimensions of the volumes enclosed by the 41 degrees C iso-temperature are 19x19x21 mm3 and 21x21x32 mm3 for the central and the thorax tumours, respectively. It is demonstrated that acoustic and thermal heterogeneities do not disturb the SAR and temperature patterns.

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Ultrasound Thermotherapy of Breast: Theoretical Design of Transducer and Numerical Simulation of Procedure

Cited by 7 publications

References 68 publications

Fast algorithm in estimating high intensity focused ultrasound induced lesions

Fast algorithm in estimating high intensity focused ultrasound induced lesions

Review of Thermal and Physiological Properties of Human Breast Tissue

An ultrasound cylindrical phased array for deep heating in the breast: theoretical design using heterogeneous models

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