Ultrasound therapy: Dose-dependent effects in LBP treatment

Cisowska-Adamiak, Małgorzata; Mackiewicz−Milewska, Magdalena; Szymkuć-Bukowska, Iwona; Hagner, Wojciech; Beuth, Wojciech

doi:10.3233/bmr-170926

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…These studies explore the mechanisms by which ultrasound waves promote wound healing, including their effects on improving blood circulation, releasing growth factors, regulating inflammation and cell apoptosis, and influencing tissue repair and regeneration. [ 21 ] Moreover, some studies have investigated the combined use of ultrasound therapy with other treatment methods and compared the efficacy of ultrasound therapy in patients with different types and severities of chronic venous ulcers. Although most of the current research results are preliminary clinical observations and experimental studies, these studies provide a theoretical basis and clinical application prospects for ultrasound therapy for chronic venous ulcers, as well as direction and motivation for future in-depth research and clinical practice.…”

Section: Discussionmentioning

confidence: 99%

NR1I2 as a core biological target in chronic venous ulcer tissues treated with ultrasound therapy

Lu,

Zhang,

Zhang

et al. 2024

Medicine

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Ultrasound therapy is a method of applying ultrasonic energy to the stimulation produced by human body to change the function and tissue state of the body in order to achieve the purpose of treating diseases. Chronic venous ulcer is a common chronic skin ulcer. GSE222503 for ultrasound therapy of chronic venous ulcers was downloaded from gene expression omnibus database, which were used to identify differentially expressed genes. Weighted gene co-expression network analysis, functional enrichment analysis, gene set enrichment analysis, immune infiltration analysis and construction and analysis of protein–protein interaction network were performed. Draw gene expression heatmaps. Comparative toxicogenomics database analysis was performed. Two hundred thirty-five differentially expressed genes were obtained. According to gene ontology analysis, in biological process analysis, they were mainly enriched in positive regulation of cellular biosynthetic process, reproductive cell development, vasculogenesis, vascular morphogenesis, and inflammatory response. In cellular component analysis, they were mainly enriched in leading edge of growing cell, extracellular matrix binding organelle, F-actin capping protein complex. In molecular function analysis, they were mainly concentrated in receptor ligand activity, cytokine receptor binding. In Kyoto encyclopedia of genes and genomes analysis, they were mainly enriched in cytokine–cytokine receptor interaction, PI3K-Akt signaling pathway, HIF-1 signaling pathway, heme biosynthesis. In weighted gene co-expression network analysis, the soft threshold power was set to 9. Thirty modules were generated. PF4, NR1I2, TTC16, H3C12, KLRB1, CYP21A2 identified by 4 algorithms (MCC, EPC, closeness, stress). Heatmap of core gene expression showed that H3C12, KLRB1, PF4, NR1I2 were all underexpressed in samples of ultrasound-treated chronic venous ulcers and overexpressed in samples of untreated chronic venous ulcers. Comparative toxicogenomics database analysis showed that H3C12, KLRB1, PF4, NR1I2 are associated with thrombophlebitis, phlebitis, vascular malformations, metabolic syndrome, ulcers, and inflammation. In samples of chronic venous ulcer tissue treated with ultrasound, NR1I2 shows low expression, while in samples of chronic venous ulcer tissue without ultrasound treatment, it shows high expression. This finding suggests a potential role of NR1I2 in the process of ultrasound therapy for chronic venous ulcers, which may be related to the therapeutic effect of ultrasound therapy on chronic venous ulcers.

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Section: Discussionmentioning

confidence: 99%

NR1I2 as a core biological target in chronic venous ulcer tissues treated with ultrasound therapy

Lu,

Zhang,

Zhang

et al. 2024

Medicine

View full text Add to dashboard Cite

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Investigation of Therapeutic Ultrasound Dose on Muscle Phantom: An Experimental Study Investigation of Therapeutic Ultrasound Dose

Gün

Karaböce

Yurdalan

2022

Clinical and Experimental Health Sciences

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Objective:The study aims to investigate the standardized, traceable dose amounts that will create the desired therapeutic physiological change in the tissue and prevent the risk of tissue damage in the light of metrology principles Methods: In the study carried out in TÜBİTAK National Metrology Institute Medical Metrology Laboratory, a muscle phantom simulating the acoustic properties of muscle tissue was created and thermocouples were placed in it. Ultrasound at different intensities and durations at 1 MHz frequency was applied to the phantom. The temperature changes measured by the thermocouples were recorded. Each measurement was repeated three times and averaged Results: 14 minutes application at 1 W/cm 2 density, 10 minutes application at 1.5 W/cm 2 density, ~7 minutes application at 2 W/cm 2 density, and ~4 minutes application at 2.5 W/cm 2 density have been achieved for the temperature range needed to produce therapeutic effect. Conclusions:In order to achieve the therapeutic effect, the ultrasound doses used in the procedure should be checked. Measurements in multilayer phantoms would be useful in future research.

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Ultrasound therapy: Dose-dependent effects in LBP treatment

Cited by 2 publications

References 15 publications

NR1I2 as a core biological target in chronic venous ulcer tissues treated with ultrasound therapy

NR1I2 as a core biological target in chronic venous ulcer tissues treated with ultrasound therapy

Investigation of Therapeutic Ultrasound Dose on Muscle Phantom: An Experimental Study Investigation of Therapeutic Ultrasound Dose

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