Ultrasound‑targeted microbubble destruction technology delivering β‑klotho to the heart enhances FGF21 sensitivity and attenuates heart remodeling post‑myocardial infarction
Chaofu Yue,
Rong Li,
Chunyan Li
et al.
Abstract:Fibroblast growth factor (FGF)21 is a peptide hormone that improves mitochondrial function and energy metabolism, and the deficiency of its co-receptor β-klotho (KLB) causes decreased FGF21 sensitivity. The present study examined whether the cardiac delivery of plasmids containing the
KLB
gene via ultrasound-targeted microbubble destruction (UTMD) enhances the efficacy of FGF21 against heart failure post-acute myocardial infarction (AMI). For this purpose, the levels of FGF21 in patients… Show more
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