Ultrasound surveillance for radiation-induced thyroid carcinoma in adult survivors of childhood cancer

Brignardello, Enrico; Felicetti, Francesco; Castiglione, Anna; Gallo, Marco; Maletta, Francesca; Isolato, G; Biasin, Eleonora; Corrias, Andrea; Palestini, N

doi:10.1016/j.ejca.2015.12.006

Cited by 20 publications

(20 citation statements)

References 30 publications

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“…Thyroid dysfunction can manifest as primary hyperthyroidism, primary hypothyroidism (either compensated or overt), central hypothyroidism, or a combination of the latter two [22, 23]. Ionizing radiation also increases the risk of both benign and malignant thyroid neoplasms [3, 8, 9, 13, 14, 16, 17, 21, 24-33]. In general, the risk of developing radiation-induced thyroid disease depends on numerous factors, including the age of the child at the time of treatment, the radiation dose delivered to the HPT axis, and the time elapsed since irradiation (Fig.…”

Section: Radiation-induced Thyroid Diseasementioning

confidence: 99%

Thyroid Sequelae of Pediatric Cancer Therapy

Waguespack

2018

Horm Res Paediatr

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The hypothalamic-pituitary-thyroid axis is a common site of unintended, acquired disease either during or after the treatment of cancer. Children treated with external radiation therapy are at the highest risk for developing a thyroid-related late effect, but thyroid dysfunction and second primary thyroid neoplasms can also occur after treatment with radiopharmaceutical agents such as ¹³¹I-metaiodobenzylguanidine. Increasingly recognized is the development of early thyroid dysfunction as an off-target consequence of the more novel cancer therapeutics such as the tyrosine kinase inhibitors and immune checkpoint inhibitors. Thyroid sequelae resulting from irradiation may manifest only after years to decades of follow-up, and their resultant clinical symptoms may be indolent and non-specific. Therefore, lifelong monitoring of the childhood cancer survivor at risk for thyroid disease is paramount. In this comprehensive review, the myriad thyroid adverse effects resulting from pediatric cancer treatment are discussed and an overview of screening and treatment of these thyroid sequelae provided.

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Section: Radiation-induced Thyroid Diseasementioning

confidence: 99%

Thyroid Sequelae of Pediatric Cancer Therapy

Waguespack

2018

Horm Res Paediatr

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“…Currently there is no consensus on the optimal surveillance strategy for thyroid cancer after radiotherapy in CCS. The use of ultrasound for early diagnosis of radiation-induced thyroid cancer may be suitable, nevertheless, routine ultrasound screening in irradiated CCS can actually not be recommended [20].…”

Section: Discussionmentioning

confidence: 99%

Screening for Subsequent Pancreatic Cancer in Childhood Cancer Survivors is Needed. A Case Report

Zadravec-Zaletel¹,

Cavlek²,

Gjidera³

2017

J Nucl Med Radiat Ther

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Introduction: The survival of children with cancer has improved considerably over the last decades which have led to a growing number of long term survivors. One of the most serious adverse outcomes in this population is subsequent primary neoplasms with the risk as high as six-fold over expected. The relative risk for subsequent pancreatic cancer in childhood cancer survivors is high, especially after subdiafragmatic radiotherapy and/or chemotherapy with alkylating agents. The survival of patient with advanced pancreatic cancer is very low, and early diagnosis is of vital importance.

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“…Follow-up durations since childhood cancer are generally too short to assess the risk for secondary malignant neoplasms in aging childhood cancer survivors. Average follow-up durations since childhood cancer vary between 6.3 and 27.3 years in studies assessing secondary breast cancer risk (Hancock et al 1993, Metayer et al 2000, Ng et al 2002, Bhatia et al 2003, Gold et al 2003, Guibout et al 2005, Inskip & Curtis 2007, Constine et al 2008, Friedman et al 2008, Marees et al 2008, Alm El-Din et al 2009, De Bruin et al 2009, Maule et al 2011, Reulen et al 2011, Cooke et al 2013, Danner-Koptik et al 2013, Little et al 2014, Dorffel et al 2015, Schaapveld et al 2015, and 5.1-27 years in studies investigating secondary thyroid carcinoma risk (Crom et al 1997, Bhatia et al 2002, Cohen et al 2007, Inskip & Curtis 2007, Constine et al 2008, Taylor et al 2009, van Beek et al 2009, Friedman et al 2010, Maule et al 2011, Vivanco et al 2012, Danner-Koptik et al 2013, Caglar et al 2014, Clement et al 2015, de Vathaire et al 2015, Dorffel et al 2015, Brignardello et al 2016. Specific subtypes of secondary malignant neoplasms and potential risk-modifying factors yet unknown may become apparent at an adv...…”

Section: Limitations Of Currently Available Literature and Recommendmentioning

confidence: 99%

“…Besides increasing the risk for differentiated thyroid carcinoma, radiotherapy involving the thyroid gland is also known to promote the occurrence of benign thyroid nodules in childhood cancer survivors (Table 11). Clinically, it may be difficult to distinguish malignant from benign thyroid nodules (Healy et al 1996, Crom et al 1997, Somerville et al 2002, Acharya et al 2003, Haddy et al 2012, Vivanco et al 2012, Kelly et al 2013, Caglar et al 2014, Agrawal et al 2016, Brignardello et al 2016. Studies investigating radiation-related thyroid carcinoma risk after childhood cancer treatment have predominantly assessed older radiotherapeutic modalities.…”

Section: :6mentioning

confidence: 99%

“…papillary or follicular thyroid carcinoma) (Black et al 1998, Taylor et al 2009). Latency periods for the development of secondary thyroid carcinoma in childhood cancer survivors vary between 0.6 and 38 years (average 12.3 years) (Table 10) (Black et al 1998, Bhatia et al 2002, Acharya et al 2003, Cohen et al 2007, Constine et al 2008, Diallo et al 2009, Taylor et al 2009, Veiga et al 2012a, Danner-Koptik et al 2013, Dorffel et al 2015, Finke et al 2015, Brignardello et al 2016. A recent study by Veiga and coworkers included pooled data from the Childhood Cancer Survivor Study cohort (Bhatti et al 2010), the Late Effects Study Group cohort (Tucker et al 1991), the Nordic countries cohort (Svahn-Tapper et al 2006) and a combined French and British cohort (de Vathaire et al 1999).…”

Section: Epidemiology and Host-related Risk Factorsmentioning

confidence: 99%

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Risk factors for subsequent endocrine-related cancer in childhood cancer survivors

Wijnen¹,

Heuvel‐Eibrink²,

Medici³

et al. 2016

Endocrine-Related Cancer

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Long-term adverse health conditions, including secondary malignant neoplasms, are common in childhood cancer survivors. Although mortality attributable to secondary malignancies declined over the past decades, the risk for developing a solid secondary malignant neoplasm did not. Endocrine-related malignancies are among the most common secondary malignant neoplasms observed in childhood cancer survivors. In this systematic review, we describe risk factors for secondary malignant neoplasms of the breast and thyroid, since these are the most common secondary endocrine-related malignancies in childhood cancer survivors. Radiotherapy is the most important risk factor for secondary breast and thyroid cancer in childhood cancer survivors. Breast cancer risk is especially increased in survivors of Hodgkin lymphoma who received moderate-to high-dosed mantle field irradiation. Recent studies also demonstrated an increased risk after lowerdose irradiation in other radiation fields for other childhood cancer subtypes. Premature ovarian insufficiency may protect against radiation-induced breast cancer. Although evidence is weak, estrogen-progestin replacement therapy does not seem to be associated with an increased breast cancer risk in premature ovarian-insufficient childhood cancer survivors. Radiotherapy involving the thyroid gland increases the risk for secondary differentiated thyroid carcinoma, as well as benign thyroid nodules. Currently available studies on secondary malignant neoplasms in childhood cancer survivors are limited by short follow-up durations and assessed before treatment regimens. In addition, studies on risk-modifying effects of environmental and lifestyle factors are lacking. Risk-modifying effects of premature ovarian insufficiency and estrogen-progestin replacement therapy on radiation-induced breast cancer require further study. 23:6Review M Wijnen et al.Subsequent endocrine-related cancer risk in CCS

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Ultrasound surveillance for radiation-induced thyroid carcinoma in adult survivors of childhood cancer

Cited by 20 publications

References 30 publications

Thyroid Sequelae of Pediatric Cancer Therapy

Thyroid Sequelae of Pediatric Cancer Therapy

Screening for Subsequent Pancreatic Cancer in Childhood Cancer Survivors is Needed. A Case Report

Risk factors for subsequent endocrine-related cancer in childhood cancer survivors

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