Ultrasound sonication prior to electrospinning tailors silk fibroin/PEO membranes for periodontal regeneration

Serôdio, Ricardo; Schickert, Sónia L.; Costa-Pinto, Ana Rita; Dias, Juliana R.; Granja, Pedro L.; Yang, Fang; Oliveira, Ana L.

doi:10.1016/j.msec.2019.01.055

Cited by 44 publications

(27 citation statements)

References 67 publications

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“…Having a fibrous structure, SF should be prone to ES without additives and the feasibility of this process has already been proven in the literature, by performing ES from the formic acid [ 104 , 105 , 106 ] or aqueous solutions [ 107 ]. Still, as the process is challenging, the majority of the studies report performing electrospinning with various co-polymers: collagen [ 108 ], PEO [ 109 , 110 , 111 , 112 ], or PVA [ 113 , 114 ]. Post-electrospinning, the fibers can be stabilized by methanol/ethanol [ 104 , 105 , 106 , 108 , 109 , 110 , 111 ], EDC-NHS [ 107 ], or GTA + HCl [ 113 ].…”

Section: Examples Of the Electrospinnable Biopolymersmentioning

confidence: 99%

“…The indicated stabilization mechanism of the alcohols or EDC-NHS is the transition of the amorphous structure into β-sheet conformation, while GTA + HCl induces chemical cross-linking. Interestingly, Zhou et al [ 114 ] and Serodito et al [ 112 ], in their articles from 2019, indicated that there is no need for additional stabilization steps. While Zhou did not provide proof of a prolonged stability of the fibers, Serodito performed 7-day-long in vitro studies, by directly seeding the human cells from the periodontal ligament (hPDLs) onto the scaffolds.…”

Section: Examples Of the Electrospinnable Biopolymersmentioning

confidence: 99%

“…In the in vitro studies, SF fibrous scaffolds have been proven to enhance the murine L929 fibroblasts adhesion, proliferation, and growth [ 106 , 109 , 113 ], enhance the human fibroblasts and keratinocyte proliferation while improving the keratinocytes’ differentiation [ 105 ]. They were also favorable for the hPDL cells adhesion and proliferation [ 112 ]. When the SF-based scaffolds were used in vivo for treating wounds in rats [ 108 , 110 ] or mice [ 111 ], excellent biocompatibility, combined with enhanced wound closure, was reported.…”

Section: Examples Of the Electrospinnable Biopolymersmentioning

confidence: 99%

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Advances in Fabricating the Electrospun Biopolymer-Based Biomaterials

Wilk

Benko

2021

JFB

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Biopolymers formed into a fibrous morphology through electrospinning are of increasing interest in the field of biomedicine due to their intrinsic biocompatibility and biodegradability and their ability to be biomimetic to various fibrous structures present in animal tissues. However, their mechanical properties are often unsatisfactory and their processing may be troublesome. Thus, extensive research interest is focused on improving these qualities. This review article presents the selection of the recent advances in techniques aimed to improve the electrospinnability of various biopolymers (polysaccharides, polynucleotides, peptides, and phospholipids). The electrospinning of single materials, and the variety of co-polymers, with and without additives, is covered. Additionally, various crosslinking strategies are presented. Examples of cytocompatibility, biocompatibility, and antimicrobial properties are analyzed. Special attention is given to whey protein isolate as an example of a novel, promising, green material with good potential in the field of biomedicine. This review ends with a brief summary and outlook for the biomedical applicability of electrospinnable biopolymers.

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Section: Examples Of the Electrospinnable Biopolymersmentioning

confidence: 99%

Section: Examples Of the Electrospinnable Biopolymersmentioning

confidence: 99%

Section: Examples Of the Electrospinnable Biopolymersmentioning

confidence: 99%

See 1 more Smart Citation

Advances in Fabricating the Electrospun Biopolymer-Based Biomaterials

Wilk

Benko

2021

JFB

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“…This phenomenon result in embrittled SF electrospun materials but can be made up by blending with PEO. 39,40…”

Section: Collagenmentioning

confidence: 99%

“…Polyethylene oxide (PEO) is an essential co-spinning agent to enhance viscosities of solutions and assure good membrane mechanical properties. 40 Keirouz proved that blending PEO with chitosan could stabilize and improve the electrospinnability for homogenous fiber formation. 81 Others reported that the addition of PEO results in decline of chitosan fiber diameters.…”

Section: Composites Materials Blendingmentioning

confidence: 99%

Biodegradable engineered fiber scaffolds fabricated by electrospinning for periodontal tissue regeneration

Ren

et al. 2020

J Biomater Appl

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Considering the specificity of periodontium and the unique advantages of electrospinning, this technology has been used to fabricate biodegradable tissue engineering materials for functional periodontal regeneration. For better biomedical quality, a continuous technological progress of electrospinning has been performed. Based on property of materials (natural, synthetic or composites) and additive novel methods (drug loading, surface modification, structure adjustment or 3 D technique), various novel membranes and scaffolds that could not only relief inflammation but also influence the biological behaviors of cells have been fabricated to achieve more effective periodontal regeneration. This review provides an overview of the usage of electrospinning materials in treatments of periodontitis, in order to get to know the existing research situation and find treatment breakthroughs of the periodontal diseases.

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Core‐Sheath‐Like Poly(Ethylene Oxide)/Beeswax Composite Fibers Prepared by Single‐Spinneret Electrospinning. Antibacterial, Antifungal, and Antitumor Activities

Kyuchyuk

Paneva

Karashanova

et al. 2022

Macromolecular Bioscience

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Composite fibrous materials are prepared from poly(ethylene oxide) (PEO) and beeswax (BW) by single-spinneret electrospinning using chloroform as a common solvent. The obtained fibers have core-sheath-like structure, as evidenced by the water contact angle values and corroborated by the results on the elemental composition of the fiber's surface determined by X-ray photoelectron spectroscopy (XPS) and by analyses with scanning electron microscopy of fibers before and after selective extraction of PEO or BW. Furthermore, the core-sheath-like structure is proven by transmission electron microscopy. This is attributed to self-assembly of BW molecules on the surface of the formed fibers driven by the incompatibility between PEO and BW. 5-Nitro-8-hydroxyquinoline (NQ) is embedded as a model drug with antibacterial, antifungal, and anticancer properties in the PEO/BW fibrous materials. XPS analyses reveal that NQ is present on the surface of the PEO/BW/NQ materials. Using a purposely designed cell for fixation of the fibrous materials the NQ release in phosphate buffer solution with рН 7.4 is followed. The new PEO/BW/NQ fibrous materials exhibit antibacterial activity against S. aureus and E. coli, antifungal effect against C. albicans, and selective anticancer activity against HeLa (human cervical adenocarcinoma cells) and SH-4 (human melanoma cells) cell lines.

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Ultrasound sonication prior to electrospinning tailors silk fibroin/PEO membranes for periodontal regeneration

Cited by 44 publications

References 67 publications

Advances in Fabricating the Electrospun Biopolymer-Based Biomaterials

Advances in Fabricating the Electrospun Biopolymer-Based Biomaterials

Biodegradable engineered fiber scaffolds fabricated by electrospinning for periodontal tissue regeneration

Core‐Sheath‐Like Poly(Ethylene Oxide)/Beeswax Composite Fibers Prepared by Single‐Spinneret Electrospinning. Antibacterial, Antifungal, and Antitumor Activities

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