Ultrasound screening for neoplasms in children up to 6 years old

Jędrzejewski, Grzegorz; Woźniak, Magdalena Maria; Pawelec, Agata; Matera, Albert; Kunach, Magdalena; Madej, Tomasz; Wieczorek, Paweł; Nowakowska, Katarzyna

doi:10.1097/md.0000000000005124

Cited by 5 publications

(6 citation statements)

References 10 publications

(14 reference statements)

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“…This is very important for appropriate prenatal management of pregnancy and delivery in order to facilitate prompt postnatal treatment (26). Similarly, ultrasound screening in pediatric population can be used to reveal lesions like tumors or other pathologies of developmental age that are undetectable by clinical examination, before the onset of clinical symptoms (27,28). This is particularly appropriate for patients with cancer predisposition, for example, in children with BWS (27,29).…”

Section: Discussionmentioning

confidence: 99%

Clinical, Genetic, and Prognostic Features of Adrenocortical Tumors in Children: A 10-Year Single-Center Experience

et al. 2020

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Background and Aims: Pediatric adrenocortical tumors (ACTs) are very rare endocrine neoplasms in childhood. In this study, we performed a retrospective analysis of children with ACT treated at our institution by examining clinical and genetic disease features, treatment strategies, and outcomes. Methods: We retrospectively analyzed a cohort of 13 children treated at the Bambino Gesù Children's Hospital from November 2010 to March 2020. Results: The median age at diagnosis was 17 months (range = 0-82 months). The female: male ratio was 3.3/1. Mixed symptomatology (>1 hormone abnormality) was the most common presentation (46.1%). In three cases, the tumor was detected during prenatal or perinatal echographic screening. All patients presented with localized disease at diagnosis and underwent total adrenalectomy. Six patients were identified as having malignancies according to the Wieneke scoring system, five benign, and two undetermined. Seven patients underwent mitotane adjuvant therapy for 12 months. There was metastatic disease in three patients, with no correlation with age or Wieneke score. The most common sites of metastases were the liver and lungs. Metastatic patients were treated with surgery (n = 2), mitotane (n = 1), chemotherapy (n = 2) associated with anti-EGFR (n = 1), or immunotherapy with anti-PD1 (pembrolizumab) (n = 1); two patients achieved complete disease remission. Overall 2-and 5-year survival rates were 100%, with a median follow-up of 5 years (range = 2-9.5 years). Two-and 5-year disease free survival was 76.9 and 84.6%, respectively (95% confidence interval = −66.78-114.76 months). All patients are alive, 12 without disease, and one with stable disease. Genetic analyses showed TP53 germline mutations in six of eight patients analyzed (five inherited, one de novo). One patient had Beckwith-Wiedemann syndrome, with mosaic paternal uniparental disomy of chromosome 11, in both neoplastic and healthy adrenal tissue. Miele et al. Adrenocortical Tumors in Children Conclusion: We report the cases of 13 patients treated for ACT, including 12 aged <4 years at diagnosis, with a relative short time from symptoms onset. Our cohort experienced an excellent prognosis. TP53 mutation was found in 75% of tested patients (6/8) confirming the need to perform genetic tests and familial counseling in this disease.

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Section: Discussionmentioning

confidence: 99%

Clinical, Genetic, and Prognostic Features of Adrenocortical Tumors in Children: A 10-Year Single-Center Experience

et al. 2020

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“…While Edmund et al concluded that screening patients with a high risk of WT did not significantly improve survival, unscreened patients are said to present at a later stage [ 12 ]. Smaller tumours found due this “aggressive” screening strategy are also more amenable to renal sparing surgery [ 13 , 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Role of Ultrasonography in the Diagnosis of Wilms’ Tumour

et al. 2022

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Background. Wilms’ tumour or nephroblastoma is the most common renal malignancy encountered in the paediatric population. Imaging findings are of great importance to the surgeon, the oncologist and the radiologist in the diagnosis and the staging and surveillance of this tumour. Material and Methods. This study was carried out as a 10-year retrospective study of patients who were diagnosed with Wilms’ tumour. Results. The study included 12 boys and 11 girls. Ultrasound and computed tomography were performed in all cases. Ultrasonography was found to be superior to the CT examination when approximating the antero-posterior and transverse diameters; the computer-tomographic examination is cited as superior for estimating the invasion of nephroblastomas. Conclusions: Ultrasound has been shown to be effective in detecting the rupture of the renal capsule, tumour calcifications and invasion of the renal vein, pelvis and ureter. However, ultrasound cannot replace CT in the detection of lymphadenopathy and the invasion of adjacent organs.

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“…Despite promising results that showed changes in approximately 25% of the examined children, these studies have not been introduced to the entire population. Another attempt was made by the RMHC Chapter in Poland, which purchased a special mobile ambulance equipped with two ultrasound rooms for pediatric ultrasound examinations [14]. These studies were cofinanced with local self-governments.…”

Section: Discussionmentioning

confidence: 99%

“…A significant number of abnormalities were related to scrotal pathologies. Undescended testes and microlithiasis can affect testis growth and are proven conditions predisposing to the cancer occurrence [14,16].…”

Section: P R E P R I N Tmentioning

confidence: 99%

Ultrasound screening for cervical, abdominal and scrotal malignant and benign abnormalities in children

et al. 2021

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IntroductionUltrasonography plays an important role in evaluation of many diseases in pediatric population. The noninvasiveness of the method allows to its wide use in children. It is a first-line diagnostic test for detecting lymphadenopathy, benign and malignant abnormalities of the thyroid gland, abdominal structures or testes in boys. The Ultrasound Screening Program “No to Cancer in Children” was introduced to detect neoplastic lesions and possible developmental disorders in children with no symptoms to allow early diagnosis.Material and methodsThe children were scanned in special mobile ambulance - Ronald McDonald Care Mobile, equipped with two high-tech ultrasound devices. Ultrasound scans, including cervical, abdominal, pelvical and scrotal ultrasound were performed in population of asymptomatic children. In the years 2006-2019, 67.594 children, 34.892 boys and 32.702 girls aged from 9 months to 6 years were examined.ResultsTotally, 18.544 various abnormalities were detected. In case of the neck they were found in 7542 children, which represent nearly 11.2% of all patients. Changes in abdominal ultrasound were found in 4.496 cases (6.65%). Abnormalities of the male reproductive system were detected in 6.474 boys (18.5%). Twelve tumors were detected.ConclusionsScreening has proved to be very useful for the early identification cancerous as well as precancerous lesions. It is also worth continuing for a reason of effective detection of other childhood anomalies.

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Ultrasound screening for neoplasms in children up to 6 years old

Cited by 5 publications

References 10 publications

Clinical, Genetic, and Prognostic Features of Adrenocortical Tumors in Children: A 10-Year Single-Center Experience

Clinical, Genetic, and Prognostic Features of Adrenocortical Tumors in Children: A 10-Year Single-Center Experience

Role of Ultrasonography in the Diagnosis of Wilms’ Tumour

Ultrasound screening for cervical, abdominal and scrotal malignant and benign abnormalities in children

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