Ultrasound scanning assessment of L-Thyroxine treatment effectiveness in a group of children with diffuse goiter

Regalbuto, Concetto; Belfiore, Antonino; Giuffrida, Dario; Ippolito, A.; Motta, Rosa Maria; Sava, Lidia

doi:10.1007/bf03347892

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…A major symptom in pediatric patients with the disease is goiter (1). It is well established that levothyroxine and iodine treatment efficiently reduces thyroid volume in children and adolescents and adults with nontoxic goiters in geographic areas with iodine deficiency (2)(3)(4). In goiter caused by AIT, significant reductions in thyroid volume during treatment with levothyroxine have been reported for adults (5).…”

Section: Discussionmentioning

confidence: 99%

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Levothyroxine Treatment Reduces Thyroid Size in Children and Adolescents with Chronic Autoimmune Thyroiditis

Svensson¹,

Ericsson

Nilsson

et al. 2006

The Journal of Clinical Endocrinology & Metabolism

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Context:The use of levothyroxine to reduce thyroid size in pediatric patients with goiter due to chronic autoimmune thyroiditis (AIT) remains controversial. In overtly hypothyroid patients, reductions in thyroid volume have been reported, whereas the effect in subclinically hypothyroid and euthyroid patients is less clear. Objective:The objective of the study was to evaluate the effect of levothyroxine treatment on thyroid size (determined with thyroid ultrasonography) in children and adolescents with AIT. Design and Setting: This study included patients with AIT treated at a university hospital outpatient clinic between 1987 and 2004.Patients: Ninety children with AIT (73 girls and 17 boys, aged 6.1-17.7 yr) were included in the study.Intervention: Intervention was treatment with levothyroxine for a median 2.8 yr (range 0.5-10.2).Main Outcome Measure: Change in thyroid volume SD score (SDS) during the study period was measured.Results: Median thyroid volume SDS was reduced in patients euthyroid (Ϫ0.4 SDS, P Ͻ 0.001), subclinically hypothyroid (Ϫ1.4 SDS, P Ͻ 0.001), and overtly hypothyroid (Ϫ1.8 SDS, P Ͻ 0.002) at diagnosis of AIT. Both hypothyroid and euthyroid patients with goiter (thyroid volume Ͼ 2.0 SDS) at baseline reduced their median thyroid volume SDS (Ϫ1.6 and Ϫ0.9, respectively, P Ͻ 0.001). Hypothyroid patients without goiter also reduced median thyroid volume SDS (Ϫ1.2, P Ͻ 0.004), whereas no change was noticed in euthyroid children without goiter. Conclusions:Levothyroxine treatment is effective in reducing thyroid volume in pediatric patients and is suggested in treatment of goiter caused by AIT, especially in cases of hypothyroid, but also in euthyroid children.

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Section: Discussionmentioning

confidence: 99%

“…Thyroid volume and levels of TSH, T 4 , and/or free T 4 , as well as a patient's height and weight at the time of each ultrasound examination, were recorded.…”

Section: Discussionmentioning

confidence: 99%

Levothyroxine Treatment Reduces Thyroid Size in Children and Adolescents with Chronic Autoimmune Thyroiditis

Svensson¹,

Ericsson

Nilsson

et al. 2006

The Journal of Clinical Endocrinology & Metabolism

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Problems in diagnosis and management of goitre in childhood and adolescence

Webb

Brewster

Newington

1996

Journal of British Surgery

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This study is a retrospective review of 17 patients aged 16 and under with a total of 18 goitres, who were investigated and treated at Bristol Children's Hospital and Bristol Royal Infirmary between 1967 and 1994. There were five neoplasms, comprising follicular adenoma (three) and papillary carcinoma (two). Other benign causes of goitre included nodular goitre (four), non-toxic hyperplasia (three) and chronic lymphocytic thyroiditis (three). The authors suggest some guidelines to help in the diagnosis and management of goitre in young patients, as a consequence of significant difficulties encountered in 12 of the 17 patients in this series.

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Clinical Evolution of Autoimmune Thyroiditis in Children and Adolescents

Fava

Oliverio²,

Giuliano³

et al. 2009

Thyroid

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In young patients with normal or mildly increased TSH levels and minimal echographic changes, AIT may remain stationary for years. In fact, patients with subclinical hypothyroidism recover a normal thyroid function in approximately 20% of cases. In patients with subclinical hypothyroidism and goiter, LT(4) therapy may induce thyroid size reduction. Screening for other autoimmune disorders is useful to identify patients that need further diagnostic assessment.

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Ultrasound scanning assessment of L-Thyroxine treatment effectiveness in a group of children with diffuse goiter

Cited by 4 publications

References 16 publications

Levothyroxine Treatment Reduces Thyroid Size in Children and Adolescents with Chronic Autoimmune Thyroiditis

Levothyroxine Treatment Reduces Thyroid Size in Children and Adolescents with Chronic Autoimmune Thyroiditis

Problems in diagnosis and management of goitre in childhood and adolescence

Clinical Evolution of Autoimmune Thyroiditis in Children and Adolescents

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