Ultrasound Receive-Side Strategies for Image Quality Enhancement in Low-Energy Illumination Based Photoacoustic Imaging

Chandramoorthi, Sowmiya; Thittai, Arun K.

doi:10.1007/978-981-15-3984-8_4

“…PAI has gained a variety implementation techniques and applications through the last three decades [3,5,9,29,30]. For instance: photoacoustic tomography (PAT) [1, 2, 4, 31 -33], multispectral optoacoustic tomography (MSOT) [5] or multispectral PAT, light emitting diode (LED) based PAI [34], optical detection PAT (OD-PAT) or also named non-contact laser ultrasound (NC-LUS) [35 -37], photoacoustic microscopy (PAM) [30,38], optical resolution photoacoustic microscopy (OR-PAM) [39], acoustic resolution photoacoustic microscopy (AR-PAM) [30], raster-scan optoacoustic mesoscopy (RSOM) [5], LED based PA microscopy (LD-PAM) [40], Second generation PA remote sensing based microscopy [41], PA endoscopy which is providing molecular contrast at considerable depths allowing for simultaneous imaging of structural and functional information [5,42,43], PA topography through an ergodic relay (PATER) [44], and photoacoustic elastography (PAE) [45 -47]. PAI has a big contribution in cancer diagnosis [5,48,49] as instance in breast cancer [4,5,9,50], which has a high record in threatening human's health, mostly females [51,52], the second most frequent cancer worldwide following lung cancer and the fifth leading cause of cancer death and a major cause of cancer death among women [53 -55].…”

Section: Introductionmentioning

confidence: 99%

A Mathematical Model for Simulating Photoacoustic Signal Generation Process in Biological Tissues

GadAllah

¹

,

Mohamed

²

,

Hefnawy

³

et al. 2023

Preprint

0

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Background: Biomedical photoacoustic imaging (PAI) is a hybrid imaging modality based on the laser-generated ultrasound waves due to the photoacoustic (PA) effect physical phenomenon that has been reported firstly by A. G. Bell in 1880. Numerical modeling-based simulation for the PA signal generation process in biological tissues helps researchers for decreasing error trials in-vitro and hence decreasing error rates for in-vivo experiments. Numerical modeling methods help in obtaining a rapid modeling procedure comparable to pure mathematics. However, if a proper simplified mathematical model can be founded before applying numerical modeling techniques, it will be a great advantage for the overall numerical model. Most scientific theories, equations, and assumptions, been proposed to mathematically model the complete PA signal generation and propagation process in biological tissues, are so complicated. Hence, the researchers, especially the beginners, will find a hard difficulty to explore and obtain a proper simplified mathematical model describing the process. That’s why this paper is introduced. Methods: In this paper we have tried to simplify understanding for the biomedical PA wave’s generation and propagation process, deducing a simplified mathematical model for the whole process. The proposed deduced model is based on three steps: a- pulsed laser irradiance, b- diffusion of light through biological tissue, and c- acoustic pressure wave generation and propagation from the target tissue to the ultrasound transducer surface. COMSOL Multiphysics, which is founded due to the finite element method (FEM) numerical modeling principle, has been utilized to validate the proposed deduced mathematical model on a simulated biological tissue including a tumor inside. Results and Conclusion: The time-dependent study been applied by COMSOL has assured that the proposed deduced mathematical model may be considered as a simplified, easy, and fast startup base for scientific researchers to numerically model and simulate biomedical PA signals’ generation and propagation process utilizing any proper software like COMSOL.

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“…PAI has gained a variety implementation techniques and applications through the last three decades [3,5,9,29,30]. For instance: photoacoustic tomography (PAT) [1, 2, 4, 31 -33], multispectral optoacoustic tomography (MSOT) [5] or multispectral PAT, light emitting diode (LED) based PAI [34], optical detection PAT (OD-PAT) or also named non-contact laser ultrasound (NC-LUS) [35 -37], photoacoustic microscopy (PAM) [30,38], optical resolution photoacoustic microscopy (OR-PAM) [39], acoustic resolution photoacoustic microscopy (AR-PAM) [30], raster-scan optoacoustic mesoscopy (RSOM) [5], LED based PA microscopy (LD-PAM) [40], Second generation PA remote sensing based microscopy [41], PA endoscopy which is providing molecular contrast at considerable depths allowing for simultaneous imaging of structural and functional information [5,42,43], PA topography through an ergodic relay (PATER) [44], and photoacoustic elastography (PAE) [45 -47]. PAI has a big contribution in cancer diagnosis [5,48,49] as instance in breast cancer [4,5,9,50], which has a high record in threatening human's health, mostly females [51,52], the second most frequent cancer worldwide following lung cancer and the fifth leading cause of cancer death and a major cause of cancer death among women [53 -55].…”

Section: Introductionmentioning

confidence: 99%

A Mathematical Model for Simulating Photoacoustic Signal Generation Process in Biological Tissues

GadAllah

¹

,

Mohamed

²

,

Hefnawy

³

et al. 2023

Preprint

0

View full text Add to dashboard Cite

Background Biomedical photoacoustic imaging (PAI) is a hybrid imaging modality based on the laser-generated ultrasound waves due to the photoacoustic (PA) effect physical phenomenon that has been reported firstly by A. G. Bell in 1880. Numerical modeling based simulation for PA signal generation process in biological tissues helps researchers for decreasing error trials in-vitro and hence decreasing error rates for in-vivo experiments. Numerical modeling methods help in obtaining a rapid modeling procedure comparable to pure mathematics. However, if a proper simplified mathematical model can be founded before applying numerical modeling techniques, it will be a great advantage for the overall numerical model. More scientific theories, equations, and assumptions through the biomedical PA imaging research literature have been proposed trying to mathematically model the complete PA signal generation and propagation process in biological tissues. However, most of them have so complicated details. Hence, the researchers, especially the beginners, will find a hard difficulty to explore and obtain a proper simplified mathematical model describing the process. That’s why this paper is introduced. Methods In this paper we have tried to simplify understanding for the biomedical PA wave’s generation and propagation process, deducing a simplified mathematical model for the whole process. The proposed deduced model is based on three steps: a- pulsed laser irradiance, b- diffusion of light through biological tissue, and c- acoustic pressure wave generation and propagation from the target tissue to the ultrasound transducer surface.

show abstract

A mathematical model for simulating photoacoustic signal generation and propagation in biological tissues

GadAllah,

Mohamed,

Hefnawy

et al. 2023

Opt Quant Electron

1

0

View full text Add to dashboard Cite

Photoacoustic (PA) medical imaging is a crossbred technique relying on light-induced ultrasonic waves due to the PA effect phenomenon recorded primarily in 1880 by A. G. Bell. Numerical simulation, also known as in-silico, studies assist scientists in minimizing incorrect PA experiments in both in-vitro and in-vivo. Numerical modeling techniques help to achieve a fast simulation process in contrast to pure mathematics alone. However, if a suitable facilitated mathematical model can be established prior to applying numerical modeling, it will be of great interest to the whole numeric model. Numerous mathematical equations, theorems, and propositions have been proposed to model the whole PA signal generation and propagation process in biological media. However, most of them are complicated and difficult to be understood by researchers, especially beginners. That’s why this paper was introduced. Our paper aims to simplify the understanding of the generation and propagation process of biomedical PA waves. We have developed a facilitated mathematical model for the entire process. The introduced developed mathematical model is based on three steps: (1) pulsed laser stimulation, (2) light diffusion, and (3) PA stress wave generation and propagation. The developed mathematical model has been implemented utilizing COMSOL Multiphysics, which relies on the finite element method (FEM) numerical modeling principle. The in-silico time-dependent study's results confirmed that the proposed mathematical model is a simple, efficient, accurate, and quick starting point for researchers to simulate biomedical PA signals' generation and propagation process utilizing any suitable software such as COMSOL multiphysics.

show abstract

Ultrasound Receive-Side Strategies for Image Quality Enhancement in Low-Energy Illumination Based Photoacoustic Imaging

Cited by 4 publications

References 49 publications

A Mathematical Model for Simulating Photoacoustic Signal Generation Process in Biological Tissues

A Mathematical Model for Simulating Photoacoustic Signal Generation Process in Biological Tissues

A Mathematical Model for Simulating Photoacoustic Signal Generation Process in Biological Tissues

A mathematical model for simulating photoacoustic signal generation and propagation in biological tissues

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