Ultrasound Promoted Green Synthesis of Chalcones of 3-Acetylcoumarin

doi:10.7598/cst2018.1502

Cited by 1 publication

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The best identified reaction conditions consisted in reacting 2,3-dihydrobenzofuran-5carbaldehyde with substituted acetophenones in ethanol, in the presence of sodium hydroxide, under ultrasound irradiation at room temperature (Figure 5A) (Adole et al, 2020). Sharma and co-workers developed an approach to get coumarin hybrids with other molecules such as maleimide, αlipoic acid and resveratrol, thus combining two biologically active structures and also synthesisized a set of chalcones presenting Frontiers in Chemistry frontiersin.org coumarin heterocycle as the ring B (Sharma et al, 2018). Arafa et al had the goal of finely-tune a new green protocol to synthesize bis-chalcones through a Claisen-Schmidt condensation.…”

Section: Ultrasound Chemistrymentioning

confidence: 99%

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

Marotta

Rossi²,

Ibba³

et al. 2022

Front. Chem.

View full text Add to dashboard Cite

The sustainable use of resources is essential in all production areas, including pharmaceuticals. However, the aspect of sustainability needs to be taken into consideration not only in the production phase, but during the whole medicinal chemistry drug discovery trajectory. The continuous progress in the fields of green chemistry and the use of artificial intelligence are contributing to the speed and effectiveness of a more sustainable drug discovery pipeline. In this light, here we review the most recent sustainable and green synthetic approaches used for the preparation and derivatization of chalcones, an important class of privileged structures and building blocks used for the preparation of new biologically active compounds with a broad spectrum of potential therapeutic applications. The literature here reported has been retrieved from the SciFinder database using the term “chalcone” as a keyword and filtering the results applying the concept: “green chemistry”, and from the Reaxys database using the keywords “chalcone” and “green”. For both databases the time-frame was 2017–2022. References were manually selected based on relevance.

show abstract

Section: Ultrasound Chemistrymentioning

confidence: 99%