Ultrasound of myxofibrosarcoma

Morag, Yoav; Lucas, David R.

doi:10.1007/s00256-021-03869-7

Cited by 10 publications

(6 citation statements)

References 31 publications

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“…[ 9 ] This tumor margin alteration can also be visualized by ultrasound, demonstrating a plate-like extension infiltrating the surrounding tissue. [ 10 ] Ultrasound is increasingly used to assess soft tissue masses for initial assessment due to its convenience, noninvasiveness, and absence of radiation. [ 11 ] Conventional ultrasound, when combined with CEUS, can provide additional diagnostic value by evaluating the perfusion pattern of soft tissue tumors.…”

Section: Discussionmentioning

confidence: 99%

Myxofibrosarcoma involving brachial plexus diagnoses by contrast-enhanced ultrasound: A case report

Liu,

Yan,

et al. 2023

Medicine

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Rationale: Myxofibrosarcoma most commonly arises as a slowly enlarging, painless mass. We describe an unusual case of low-grade myxofibrosarcoma in the axillary fossa, which infiltrated the brachial plexus, axillary artery, and axillary vein, causing severe pain. The low incidence and complex anatomical structure make imaging examination and surgery face great challenges. To the best of our knowledge, such presentation of a low-grade myxofibrosarcoma that showed an extreme infiltrative growth pattern and presented severe pain has not been reported before. Patient concerns: We reported a case of low-grade myxofibrosarcoma developed around the axillary neurovascular bundle, with multiple peripheral metastases in an 87-year-old male. Physical examination revealed a mass on the right axillary fossa measuring 5 × 4 cm. The patient underwent computed tomography but no definite diagnosis was obtained. Because he had claustrophobia and could not perform MRI examination. Thus, he underwent conventional ultrasound and contrast-enhanced ultrasound. Ultrasonic examination not only accurately determines the invasion scope of the tumor, but also clearly shows that the nerve has suffered from the invasion of the exogenous tumor and multiple metastatic foci around it. The contrast enhancement mode of the tumor showed centripetal high-enhancement, uneven internal enhancement, visible enhanced bridge, and non-enhancing central area. Diagnoses: Combined with the results of conventional ultrasound and contrast-enhanced ultrasound, we highly suspected it to be soft tissue sarcoma, giving strong clinical assistance. Interventions: Given the risk of sarcoma implantation along the needle track and the underestimation of tumor malignancy, an excisional biopsy was considered the most practical choice to avoid unnecessary pain and potential implantation. Outcomes: The patient underwent surgery and a histopathological examination of the lesion confirmed it as low-grade myxofibrosarcoma. Lessons subsections: This report describes a rare case of myxofibrosarcoma of the axillary fossa. High-resolution ultrasound is increasingly used for the initial assessment of soft-tissue masses. However, there are few reports about the ultrasound and contrast-enhanced ultrasound examinations of myxofibrosarcoma. Accurate preoperative diagnosis and proper treatment strategies are critical in managing patients with myxofibrosarcoma. Our case may provide diagnosis experiences and will help better understand and treat this disease.

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Section: Discussionmentioning

confidence: 99%

Myxofibrosarcoma involving brachial plexus diagnoses by contrast-enhanced ultrasound: A case report

Liu,

Yan,

et al. 2023

Medicine

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“…In addition, US is ideal in directing cutaneous biopsies. In US, MFS reveals a predominantly hypoechoic heterogeneous [20]. The presence of tail-like extensions along the fascial layer or ill-defined echog changes in the adjacent subcutaneous fat may be identified.…”

Section: Ultrasonographymentioning

confidence: 98%

Biology and Management of High-Grade Myxofibrosarcoma: State of the Art and Future Perspectives

Nishio,

Nakayama

2023

Diagnostics

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Myxofibrosarcoma (MFS) is one of the most common adult soft tissue sarcomas, typically arising in the extremities. Histologically, MFS is classified into three grades: low, intermediate, and high. Histological grades correlate with distant metastases and tumor-associated mortality. The diagnosis of MFS is challenging due to a lack of well-characterized immunohistochemical markers. High-grade MFS displays highly complex karyotypes with multiple copy number alterations. Recent integrated genomic studies have shown the predominance of somatic copy number aberrations. However, the molecular pathogenesis of high-grade MFS remains poorly understood. The standard treatment for localized MFS is surgical resection. The systemic treatment options for advanced disease are limited. This review provides an updated overview of the clinical and imaging features, pathogenesis, histopathology, and treatment of high-grade MFS.

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“…At US examination, the formation appears extremely inhomogeneous, with disorganized hypo-an-echogenic areas: these lesions may appear as cysts but were justified by their high-water content [3] .…”

Section: Case Reportmentioning

confidence: 99%

An aggressive soft-tissue sarcoma of the extremity: A myxofibrosarcoma, grade 3 (FNCLCC system)

Montatore,

Masino,

Muscatella

et al. 2024

Radiology Case Reports

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Ultrasound of myxofibrosarcoma

Cited by 10 publications

References 31 publications

Myxofibrosarcoma involving brachial plexus diagnoses by contrast-enhanced ultrasound: A case report

Myxofibrosarcoma involving brachial plexus diagnoses by contrast-enhanced ultrasound: A case report

Biology and Management of High-Grade Myxofibrosarcoma: State of the Art and Future Perspectives

An aggressive soft-tissue sarcoma of the extremity: A myxofibrosarcoma, grade 3 (FNCLCC system)

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