Objectives
The purpose of this study was to evaluate the efficacy of the combination of 2‐dimensional (2D) and 3‐dimensional (3D) contrast‐enhanced sonography in discriminating between benign and malignant small adnexal masses.
Methods
Selected patients were evaluated with both 2D and 3D contrast‐enhanced sonography after conventional sonography before undergoing any surgery. Time‐intensity curves for 2D contrast‐enhanced sonography were constructed by using contrast‐enhanced sonographic software. A vascular perfusion characteristic analysis was achieved by 2D and 3D contrast‐enhanced sonography. Results were finally verified by surgery.
Results
Forty‐seven cases of benign and 10 cases of malignant small adnexal masses were discovered. Significant differences in perfusion patterns, time‐intensity curve shapes for 2D contrast‐enhanced sonography, grayscale contrast‐enhanced sonography, and blood flow imaging on 3D contrast‐enhanced sonography were observed between benign and malignant masses (P< .05). Two‐dimensional contrast‐enhanced sonography, 3D contrast‐enhanced sonography, parallel combination of 2D and 3D contrast‐enhanced sonography, and serial combination of 2D and 3D contrast‐enhanced sonography all reached diagnostic sensitivity of 100% for discriminating benign from malignant masses, whereas specificity values were 61.7%, 63.8%, 68.1%, and 57.4%, respectively. Areas under the receiver operating characteristic curves were 0.809, 0.819, 0.840, and 0.787.
Conclusions
Two‐dimensional contrast‐enhanced sonography is of high value in distinguishing malignant from benign small adnexal masses; 3D contrast‐enhanced sonography provides richer and more useful information for evaluation of these masses. Diagnostic sensitivity of 100% can be achieved when using a serial combination of 2D and 3D contrast‐enhanced sonography, although specificity needs further improvement.