Ultrasound Neuromodulation Inhibits Seizures in Acute Epileptic Monkeys

Zou, Junjie; Meng, Long; Lin, Zhengrong; Qiao, Yanbo; Tie, Changjun; Wang, Yibo; Huang, Xiaowei; Yuan, Ti‐Fei; Chi, Yajie; Wen, Minru; Niu, Lili; Guo, Yanwu; Zheng, Hairong

doi:10.1016/j.isci.2020.101066

Cited by 47 publications

(37 citation statements)

References 33 publications

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“…It was shown that LIFU significantly decreased ictal spiking activity and significantly reduced all aforementioned behavioral seizure parameters, except for the seizure interval time which was increased in these epileptic monkeys ( Lin et al, 2020 ). Similar results were later reported by Zou et al (2020) by targeting LIFU to the right hand motor area for 15 min in an acute monkey model ( Zou et al, 2020 ). Both studies confirm that LIFU seems to be effective in higher-order animals and thereby paved the way for translation of this neuromodulation technique to humans.…”

Section: Low Intensity Focused Ultrasoundsupporting

confidence: 89%

Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy

et al. 2022

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Epilepsy affects about 1% of the population. Approximately one third of patients with epilepsy are drug-resistant (DRE). Resective surgery is an effective treatment for DRE, yet invasive, and not all DRE patients are suitable resective surgery candidates. Focused ultrasound, a novel non-invasive neurointerventional method is currently under investigation as a treatment alternative for DRE. By emitting one or more ultrasound waves, FUS can target structures in the brain at millimeter resolution. High intensity focused ultrasound (HIFU) leads to ablation of tissue and could therefore serve as a non-invasive alternative for resective surgery. It is currently under investigation in clinical trials following the approval of HIFU for essential tremor and Parkinson’s disease. Low intensity focused ultrasound (LIFU) can modulate neuronal activity and could be used to lower cortical neuronal hyper-excitability in epilepsy patients in a non-invasive manner. The seizure-suppressive effect of LIFU has been studied in several preclinical trials, showing promising results. Further investigations are required to demonstrate translation of preclinical results to human subjects.

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Section: Low Intensity Focused Ultrasoundsupporting

confidence: 89%

Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy

et al. 2022

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“…Chen et al (2020) showed that acute epileptic neuronal activity in rats was significantly suppressed by LI-TUS that targeted the cortex, hippocampus, and thalamus regions (MI 0.75, DC 30%, and 600 s of total exposure time) (Chen et al, 2020). In a study with monkeys, Zou et al (2020) applied LI-TUS at a frequency of 800 kHz directed at the PFC resulting in significantly reduced number of seizures and increased inter-seizure interval time than in the sham group (Zou et al, 2020).…”

Section: Neuromodulatory Effect Of Tus In Animalsmentioning

confidence: 99%

Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review

et al. 2021

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Background: Although low-intensity transcranial ultrasound stimulation (LI-TUS) has received more recognition for its neuromodulation potential, there remains a crucial knowledge gap regarding the neuromodulatory effects of LI-TUS and its potential for translation as a therapeutic tool in humans.Objective: In this review, we summarized the findings reported by recently published studies regarding the effect of LI-TUS on neuromodulation in both animals and humans. We also aim to identify challenges and opportunities for the translation process.Methods: A literature search of PubMed, Medline, EMBASE, and Web of Science was performed from January 2019 to June 2020 with the following keywords and Boolean operators: [transcranial ultrasound OR transcranial focused ultrasound OR ultrasound stimulation] AND [neuromodulation]. The methodological quality of the animal studies was assessed by the SYRCLE's risk of bias tool, and the quality of human studies was evaluated by the PEDro score and the NIH quality assessment tool.Results: After applying the inclusion and exclusion criteria, a total of 26 manuscripts (24 animal studies and two human studies) out of 508 reports were included in this systematic review. Although both inhibitory (10 studies) and excitatory (16 studies) effects of LI-TUS were observed in animal studies, only inhibitory effects have been reported in primates (five studies) and human subjects (two studies). The ultrasonic parameters used in animal and human studies are different. The SYRCLE quality score ranged from 25 to 43%, with a majority of the low scores related to performance and detection bias. The two human studies received high PEDro scores (9/10).Conclusion: LI-TUS appears to be capable of targeting both superficial and deep cerebral structures to modulate cognitive or motor behavior in both animals and humans. Further human studies are needed to more precisely define the effective modulation parameters and thereby translate this brain modulatory tool into the clinic.

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“…Ultrasound deep brain stimulation (UDBS) has been established as a noninvasive neuromodulation method with high spatial resolution and penetration depth [7]. The efficacy and safety of UDBS have been confirmed in rodents [8,9], nonhuman primates [10,11], and humans [12,13]. In addition, in rodents, UDBS of the lateral cerebellar nucleus enhanced rehabilitation through the restoration of interhemispheric balance in a mouse stroke model [14], UDBS of the subthalamic nucleus (STN) enhanced motor function in a mouse model of Parkinson's disease (PD) [15], and UDBS of the ventral tegmental area (VTA) resulted in recovery from disorders of consciousness in mice having received general anesthesia [16].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Deep Brain Stimulation Modulates Body Temperature in Mice

Pang

Wen

Zhong

et al. 2022

IEEE Trans. Neural Syst. Rehabil. Eng.

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Body temperature plays a critical role in rehabilitation, and numerous studies proved that the regulation of body temperature contributes to the sensorimotor recovery of patients with brain diseases such as stroke. The hypothalamus plays a key role in thermoregulation. Ultrasound deep brain stimulation (UDBS) can noninvasively modulate deep brain nuclei and have potential applications in the treatment of Parkinson's disease, Alzheimer's disease, and depression, among others. The purpose of this study was to investigate whether ultrasound stimulation of the hypothalamus could regulate body temperature in free-moving mice. Results showed that thermoregulation was related to ultrasonic parameters (pulse repetition frequency (PRF), duty cycle, total time, and acoustic pressure). UDBS of the preoptic area of the anterior hypothalamus at 500 Hz PRF could significantly reduce body temperature (ΔT = -0.25 ± 0.073 °C at t = 5 min, ΔT = -0.51 ± 0.19 °C at t = 10 min, ΔT = -0.84 ± 0.27 °C at t = 15 min). Meanwhile, UDBS of the dorsomedial hypothalamus at 10 Hz PRF triggered a significant increase in body temperature (ΔT = 0.5 ± 0.077 °C at t = 5 min, ΔT = 1.16 ± 0.23 °C at t = 10 min). These results suggest that UDBS, as a noninvasive neuromodulation tool, may play a key role in the future clinical treatment of malignant hyperthermia and hypothermia.

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Ultrasound Neuromodulation Inhibits Seizures in Acute Epileptic Monkeys

Cited by 47 publications

References 33 publications

Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy

Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy

Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review

Ultrasound Deep Brain Stimulation Modulates Body Temperature in Mice

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