Ultrasound movement patterns of fetuses with chromosome anomalies

Boué, J; P, Vignal; Aubry, J. P.; Aubry, M. C.; Aleese, J. Mac

doi:10.1002/pd.1970020110

Cited by 34 publications

(26 citation statements)

References 3 publications

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“…The autopsy results confirmed this finding. Interestingly, fetal hyperactivity with jerky movements was noted in 60% of our cases, in keeping with previous data from fetuses with Down syndrome or hypothyroidism [3,11]. One possible explanation of this finding is overexpression of central adrenergic receptors, as recently described in a mouse model of Down syndrome associated with high type II iodothyronine deiodinase activity in the brain [12].…”

Section: Discussionsupporting

confidence: 79%

Thyroid Function in Fetuses with Down Syndrome

Luton

Azria

Polak³

et al. 2012

Horm Res Paediatr

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Background/Aims: A mild increase in thyrotropin (thyroid-stimulating hormone; TSH) is common among Down syndrome patients but is rarely detected by neonatal screening at birth. We hypothesized that Down syndrome was associated with fetal hypothyroidism and tried to determine whether Down syndrome fetuses had evidence of hypothyroidism. Methods: We performed a prospective observational study on 13 fetuses with Down syndrome diagnosed prenatally. TSH and free thyroxine (FT4) levels were measured in fetal blood. The results were analyzed and compared with the findings from fetal sonography and histopathology. Results: Of the 13 fetuses, 6 had TSH values greater than the 95th percentile, and FT4 values were low. None of the fetuses had sonographic evidence of goiter. The thyroids were normal by gross examination but exhibited small follicles and histological features suggesting delayed maturation. Conclusion: The absence of goiter even in fetuses with hyperthyrotropinemia suggests a mild decrease in TSH responsiveness.

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Section: Discussionsupporting

confidence: 79%

Thyroid Function in Fetuses with Down Syndrome

Luton

Azria

Polak³

et al. 2012

Horm Res Paediatr

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“…The need for fetal karyotyping has al ready been emphasized [6,7], The results of the French studies confirm and specify the frequency of chromosomal abnormalities in these situations.…”

Section: Discussionsupporting

confidence: 58%

Interest of Biology in the Management of Pregnancies where a Fetal Malformation Has Been Detected by Ultrasonography

Boué

Müller²,

Briard³

et al. 1988

Fetal Diagn Ther

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The results of two French collaborative studies are reported with respect to chromosomal and biochemical analyses following the ultrasonographic detection of a fetal anomaly. Overall, chromosomal anomalies were observed in 14.8%, ranging from 8.6% in isolated single malformations to 40.5% in multiple fetal malformations associated with intrauterine growth retardation. Acetylcholinesterase (AChE) electrophoresis was performed on the amniotic fluid of 64 cases of ultrasonographically diagnosed isolated hydrocephalus. 8 cases of previously unsuspected open neural tube defects were diagnosed by AChE. Digestive microvillar enzyme assays were useful in the precise diagnosis of suspected gastrointestinal anomaly. The correlation of the results of ultrasonography and chromosomal and biochemical analyses is the basis for the diagnosis and the prognosis of pregnancy.

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“…Furthermore, fetuses from 17 to 20 weeks made jerky or slow flexion and extension movements of the trunk, sometimes accompanied by movement of a single limb. Boue, Vignal, Aubrey, and Aleese (1982) reported that healthy fetuses at 18-20 weeks performed slow, supple, and harmonious movements with isolated leg movements, in contrast to the synchronized movements of the whole body with twitches and kicking, as frequently noted at 12-13 weeks. Moreover, some movement patterns occurred more frequently than others at 7-19 weeks of gestation.…”

Section: -D Ultrasonographic Observation Of the Entire Fetal Bodymentioning

confidence: 84%

Ultrasound for evaluation of fetal neurobehavioural development: from 2‐D to 4‐D ultrasound

Hata

Dai

Marumo

2009

Infant and Child Development

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With respect to the assessment of fetal behaviour, there have been numerous reports on the conventional two-dimensional (2-D) ultrasonographic evaluation of fetal movements. However, there are some limitations regarding the assessment of fetal movements using 2-D ultrasound. Because of the 2-D character of real-time scanning, fetal movements outside the scanning plane cannot be displayed on the monitor. The advent of three-dimensional (3-D) ultrasound significantly advanced fetal and placental evaluation in normal and abnormal pregnancies. The introduction of fourdimensional (4-D) ultrasound techniques would allow the assessment of fetal behavioural assessment in three dimensions in real time during pregnancy. We present the latest 4-D sonographic techniques and recent 4-D sonographic studies on fetal behaviour, especially fetal whole-body movements and facial expressions in all three trimesters of pregnancy, and the continuation of behaviour from the fetal to neonatal period. 2-D does not appear capable or comparable to 4-D ultrasound in terms of evaluating early fetal facial expressions. Moreover, we describe the safety of 3-D/4-D ultrasound during pregnancy. This novel technique may assist in the evaluation of fetal behaviour, and offer potential advantages relative to conventional 2-D ultrasound. 4-D ultrasound may be an important modality in future research on fetal neurobehavioural development, although some limitations regarding the assessment of fetal behaviour by means of 4-D ultrasonography still remain unresolved.

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Ultrasound movement patterns of fetuses with chromosome anomalies

Cited by 34 publications

References 3 publications

Thyroid Function in Fetuses with Down Syndrome

Thyroid Function in Fetuses with Down Syndrome

Interest of Biology in the Management of Pregnancies where a Fetal Malformation Has Been Detected by Ultrasonography

Ultrasound for evaluation of fetal neurobehavioural development: from 2‐D to 4‐D ultrasound

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