Ultrasound-modulated optical tomography in reflection mode with ring-shaped light illumination

Kim, Chulhong; Song, Kwang Hyun; Maslov, Konstantin; Wang, Lihong V.

doi:10.1117/1.3088224

Cited by 12 publications

(10 citation statements)

References 16 publications

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“…They have demonstrated that detection of light-absorbing inclusions inside the investigated samples is possible using this approach. Hisaka and Sasakura, 16 Kim et al., 17 and Hong-Bo et al. 18 presented reflection-mode AOI setups with a light source and detector located above the US transducer, all at fixed positions on the same side of the sample.…”

Section: Introductionmentioning

confidence: 99%

Reflection-mode acousto-optic imaging using a one-dimensional ultrasound array with electronically scanned focus

Nowak

Steenbergen

2020

J. Biomed. Opt.

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. Significance: Practical implementation of acousto-optic imaging (AOI) encounters difficulties that prevent it from rapid adoption in clinical use. In many practical medical applications, the region of interest may be accessed only from one side, and using a water tank for coupling is not feasible. The solution might be to use reflection-mode imaging with an electronically scanned ultrasound (US) focus. Such an approach, however, entails considerable challenges. Aim: The possibilities of detecting and localizing light-absorbing inclusions inside turbid media by combining reflection-mode AOI conducted using a one-dimensional US array with electronic scanning of the US focus are investigated experimentally and signal processing algorithms that could be used for this purpose are introduced. Approach: We determine the speckle contrast decrease due to the acousto-optic effect as a function of the US focal point coordinates. Different signal postprocessing techniques are investigated. Results: A significant decrease in the determined speckle contrast difference values is observed due to the presence of light-absorbing inclusions. However, local minima occur in the plots only under specific conditions. Subtracting individual distributions and determining symmetry deviations allow for localizing the inclusions. Conclusions: Detection and localization of optically distinct regions are possible using the introduced approach. Signal postprocessing is required in a general case.

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Section: Introductionmentioning

confidence: 99%

Reflection-mode acousto-optic imaging using a one-dimensional ultrasound array with electronically scanned focus

Nowak

Steenbergen

2020

J. Biomed. Opt.

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“…Some researchers have gained progress in this regard. Kim et al used ring-shaped light illumination [24] and intense acoustic bursts [25] to enhance ultrasound-modulated optical signals. Murray et al used a photorefractive crystal-based interferometry system to improve the efficiency with which ultrasound-tagged photons were detected [26] .…”

Section: -3mentioning

confidence: 99%

Noninvasive blood glucose measurement by ultrasound-modulated optical technique

Zhu¹,

Lin²,

Lin³

et al. 2013

中国光学快报

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We present a method for the noninvasive measurement of blood glucose levels, which are determined by the ultrasound-modulated optical technique. The method is based on the optical scattering coefficient. A sensitivity analysis of the ultrasound-modulated light signals in a scattering medium is conducted. Glucose concentrations in intralipid and hemoglobin solutions are measured using the modulation depth of ultrasound-modulated scattered light. The effects of incident light intensity and sample temperature on the ultrasound-modulated signals are also estimated. Preliminary experimental results suggest that the proposed method is a promising technique for noninvasive blood glucose measurement.

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“…Scattering media insonified by focused ultrasound exhibit changes in their local scatterer displacement and refractive index, and accordingly modulate photons traversing the acoustic focal region [32][33][34][35] . By exploiting the strengths of both optical and ultrasound imaging, UOT can overcome the limitations of pure optical imaging and provide imaging at depth in the diffusive regime with enhanced spatial resolution [36][37][38][39][40][41][42] .…”

mentioning

confidence: 99%

Ultrasound-modulated optical glucose sensing using a 1645 nm laser

Park

Baik

Kim

et al. 2020

Sci Rep

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Regular and frequent blood glucose monitoring is vital in managing diabetes treatment plans and preventing severe complications. Because current invasive techniques impede patient compliance and are not infection-free, many noninvasive methods have been proposed. Among them, optical methods have drawn much attention for their rich optical contrast, but their resolution is degraded in deep tissue. Here, we present an ultrasound-modulated optical sensing (UoS) technique to noninvasively monitor glucose that uses an infrared laser (1645 nm) and a single-element focused ultrasound transducer. Focused ultrasound waves can acoustically localize diffused photons in scattering media, and thus optical contrast can be represented with much enhanced spatial resolution. to maximize the signal-to-noise ratio, we compared the modulation depths of UoS signals in both continuous and burst ultrasound transmission modes. finally, UoS measurements of various glucose concentrations are presented and compared with those acquired in phantoms with a conventional diffuse optical sensing method. The UOS measurements in a 20 mm thick tissue-mimicking phantom show 26.6% accuracy in terms of mean absolute relative difference (MARD), which indicates the great potential of the proposed technique as a noninvasive glucose sensor. Diabetes mellitus is a chronic metabolic disorder that causes high blood sugar (glucose) levels due to either insufficient production of insulin or inadequate cellular response to the produced insulin 1. Diabetes can lead to serious complications, such as cardiovascular disease, stroke, blindness, chronic renal failure, neuropathy, or even death 2-4. As of 2019, it is estimated that 463 million people are suffering from diabetes worldwide, and this population is projected to reach 700 million by 2045 5. In 2012, the total cost of diagnosed diabetes in the USA was estimated to be $245 billion, and in 2013 over five million people between 20-79 years of age were estimated to die from diabetes-associated causes worldwide 6,7. Although there is no known cure for the disease, diabetic patients can minimize complications through timely and constant care and treatment in conjunction with regular blood glucose monitoring. Current glucose sensors require either drawing a drop of blood by finger-pricking or inserting the sensor under the skin. The repetitive use of these invasive devices causes pain and can lead to infection, tissue damage, or reduced patient compliance. Accordingly, noninvasive glucose sensors have been increasingly sought in recent decades 8-12. Most noninvasive sensors are based on electromagnetic (EM) waves, especially within optical wavelengths, because these waves interact richly with various components of biological tissues. Raman spectroscopy, using near-infrared (NIR) and mid-infrared (MIR) illumination, detects the Raman shift from inelastic scattering by glucose molecules. It provides high specificity and is relatively robust to water and temperature changes, but requires a long collection time 13,14....

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Ultrasound-modulated optical tomography in reflection mode with ring-shaped light illumination

Cited by 12 publications

References 16 publications

Reflection-mode acousto-optic imaging using a one-dimensional ultrasound array with electronically scanned focus

Reflection-mode acousto-optic imaging using a one-dimensional ultrasound array with electronically scanned focus

Noninvasive blood glucose measurement by ultrasound-modulated optical technique

Ultrasound-modulated optical glucose sensing using a 1645 nm laser

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