Ultrasound modulated bioluminescence tomography with a single optical measurement

Abstract

Ultrasound modulated bioluminescence tomography is an imaging method which can be formulated as a hybrid inverse source problem. In the regime where light propagation is modeled by a radiative transfer equation, previous approaches to this problem require large numbers of optical measurements (Bal et al 2016 SIAM J. Math. Anal. 48 1332). Here we propose an alternative solution for this inverse problem which requires only a single optical measurement in order to reconstruct the isotropic source. Specifically, we derive two inversion formulae based on Neumann series and Fredholm theory respectively, and prove their convergence under sufficient conditions. The resulting numerical algorithms are implemented and experimented to reconstruct both continuous and discontinuous sources in the presence of noise.

Dual-modality bioluminescence and ultrasound 3D 360-degree imaging system for small animal tumor imaging using homemade transducers

“…Its integration with BLT enhances the accuracy of tumor localization and reconstruction [8]. Researchers have effectively used US imaging to guide BLT reconstruction, improving the precision of functional and anatomical imaging [9,10]. However, aligning these two modalities, especially with handheld US transducers, presents challenges in terms of complexity and time efficiency.…”

Acousto-electric Inverse Source Problem

“…In this work we consider an alternative approach to the inverse source problem which, in some sense, is in the spirt of several recently proposed hybrid imaging modalities [3,6,11,20,26,31,37]. In these methods, a wavefield is used to control the material properties of a medium of interest, which is then probed by a second wavefield [6,7,4,14,12,13,35,27,24,15,29,30]. Here we exploit the acoustoelectric effect, in which the density of charge carriers and conductivity are spatially modulated by an acoustic wave [28,33].…”