Ultrasound‐Mediated Synthesis of Novel 1,2,3‐Triazole‐Based Pyrazole and Pyrimidine Derivatives as Antimicrobial Agents

Dofe, Vidya S.; Sarkate, Aniket P.; Shaikh, Zarina M.; Gill, Charansingh H.

doi:10.1002/jhet.2935

Cited by 22 publications

(9 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High pressure (18,000 atomic pressures) and temperature (2000–5000 K) are generated by acoustic cavitation, which influence chemical transformations [ 20 , 21 ]. The use of ultrasonication in synthesis has grown in popularity in recent years [ 22 , 23 , 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Oxoquinoline-1(2H)-Carboxamide as Antiproliferative and Antioxidant Agents: An Experimental and In-Silico Approach to High Altitude Related Disorders

Ali

Warsi

et al. 2022

Molecules

View full text Add to dashboard Cite

At high altitudes, drops in oxygen concentration result in the creation of reactive oxygen and nitrogen species (RONS), which cause a variety of health concerns. We addressed these health concerns and reported the synthesis, characterization, and biological activities of a series of 10 oxoquinolines. N-Aryl-7-hydroxy-4-methyl-2-oxoquinoline-1(2H)carboxamides (5a–j) were accessed in two steps under ultrasonicated irradiation, as per the reported method. The anticancer activity was tested at 10 µM against a total of 5 dozen cancer cell lines obtained from nine distinct panels, as per the National Cancer Institute (NCI US) protocol. The compounds 5a (TK-10 (renal cancer); %GI = 82.90) and 5j (CCRF-CEM (Leukemia); %GI = 58.61) showed the most promising anticancer activity. Compound 5a also demonstrated promising DPPH free radical scavenging activity with an IC50 value of 14.16 ± 0.42 µM. The epidermal growth factor receptor (EGFR) and carbonic anhydrase (CA), two prospective cancer inhibitor targets, were used in the molecular docking studies. Molecular docking studies of ligand 5a (docking score = −8.839) against the active site of EGFR revealed two H-bond interactions with the residues Asp855 and Thr854, whereas ligand 5a (docking = −5.337) interacted with three H-bond with the residues Gln92, Gln67, and Thr200 against the active site CA. The reported compounds exhibited significant anticancer and antioxidant activities, as well as displayed significant inhibition against cancer targets, EGFR and CA, in the molecular docking studies. The current discovery may aid in the development of novel compounds for the treatment of cancer and oxidative stress, and other high altitude-related disorders.

show abstract

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Oxoquinoline-1(2H)-Carboxamide as Antiproliferative and Antioxidant Agents: An Experimental and In-Silico Approach to High Altitude Related Disorders

Ali

Warsi

et al. 2022

Molecules

View full text Add to dashboard Cite

show abstract

“…N ‐heterocycles have been of great research interest because of their diverse biological activities . Diazole and triazole derivatives with excellent fungicide activities have been commercialized as pharmaceuticals (miconazole) and agrochemicals (propiconazole), respectively.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Herbicidal Activity of 1,2,4‐Triazole Derivatives Containing a Pyrazole Moiety

Zhai

Tan

et al. 2019

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

A series of triazole derivatives containing a pyrazole moiety were synthesized and characterized by 1H NMR, 13C NMR, and HRMS. The herbicidal activities of these compounds were tested against lettuce and bentgrass. Most of the tested compounds were moderately herbicidal activity against lettuce and bentgrass. Among them, compounds 6f and 6g had the highest herbicidal activity (80% inhibitory) against lettuce and bentgrass.

show abstract

“…The 1,2,3‐triazole‐linked pyrimidine nucleus has derived a great consideration owing to remarkable biological properties, such as antibacterial, anticancer, antivirus, and antituberculosis. Dofe et al reported the synthesis of novel 1,2,3‐triazole‐based pyrimidine as potential anti‐microbial agents . Liu et al developed the synthesis of novel 1,2,3‐triazole‐pyrimidine‐urea hybrids as potential anti‐cancer agents .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 1,2,3 triazole‐linked pyrimidines catalyzed by mg‐Al‐LDH‐immobilized‐CuI as a heterogeneous catalyst

Rezaeimanesh

Bakherad

Nasr‐Isfahani

et al. 2019

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

A useful and efficient procedure was obtained for the synthesis of 1,2,3-triazole-linked pyrimidines via click reaction of propynylated pyrimidine and aromatic azides in the presence of Mg-Al-LDH-immobilized-CuI with high-toexcellent yields. Moreover, the prepared catalyst was characterized by the FT-IR spectroscopy, XRD, BET, SEM, and ICP techniques. The developed synthetic technique offers numerous advantages such as a clean reaction, easy workup, high reaction yields, and short reaction time.

show abstract

Ultrasound‐Mediated Synthesis of Novel 1,2,3‐Triazole‐Based Pyrazole and Pyrimidine Derivatives as Antimicrobial Agents

Cited by 22 publications

References 31 publications

Green Synthesis of Oxoquinoline-1(2H)-Carboxamide as Antiproliferative and Antioxidant Agents: An Experimental and In-Silico Approach to High Altitude Related Disorders

Green Synthesis of Oxoquinoline-1(2H)-Carboxamide as Antiproliferative and Antioxidant Agents: An Experimental and In-Silico Approach to High Altitude Related Disorders

Synthesis and Herbicidal Activity of 1,2,4‐Triazole Derivatives Containing a Pyrazole Moiety

Synthesis of 1,2,3 triazole‐linked pyrimidines catalyzed by mg‐Al‐LDH‐immobilized‐CuI as a heterogeneous catalyst

Contact Info

Product

Resources

About