Abstract:Background:
Tumor-associated macrophages (TAMs) are crucial for non-small cell lung cancer (NSCLC) development.
Objective:
In this study, polylactic acid-co-glycolic acid (PLGA)-polyethylenimine (PEI) nanobubbles (NBs) carrying STAT6 siRNA were prepared and combined with ultrasound-mediated nanobubbles destruction (UMND) to silence the STAT6 gene, ultimately repolarizing TAMs from the M2 to the M1 phenotype, treating NSCLC in vitro.
Methods:
PLGA-PEI NBs-siRNA were prepared and characterised, and their res… Show more
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