Ultrasound-mediated gene delivery into suspended plant cells using polyethyleneimine-coated mesoporous silica nanoparticles

Zolghadrnasab, Maryam; Mousavi, Amir; Farmany, Abbas; Arpanaei, Ayyoob

doi:10.1016/j.ultsonch.2021.105507

Cited by 33 publications

(31 citation statements)

References 60 publications

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“…This shows the impact of silica nanoparticle concentration on germination rate. Furthermore, the recent research by Maryam et al [118] is worth mentioning, where the researchers developed poly-ethyleneimine (PEI) coated MSNs. The particles were loaded with genetic material (pDNA) for an efficient and successful transfection to plant cells via ultrasonic treatment.…”

Section: Agricultural Applications Of Snpsmentioning

confidence: 99%

A Comprehensive Review of Synthesis, Applications and Future Prospects for Silica Nanoparticles (SNPs)

Akhter

Rao

Abbasi

et al. 2022

Silicon

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Silica nanoparticles (SNPs) have shown great applicability potential in a number of fields like chemical, biomedical, biotechnology, agriculture, environmental remediation and even wastewater purification. With remarkably instinctive properties like mesoporous structure, high surface area, tunable pore size/diameter, biocompatibility, modifiability and polymeric hybridizability, the SNPs are growing in their applicable potential even further. These particles are shown to be non-toxic in nature, hence safe to be used in biomedical research. Moreover, the molecular mobilizability onto the internal and external surface of the particles makes them excellent carriers for biotic and non-biotic compounds. In this respect, the present study comprehensively reviews the most important and recent applications of SNPs in a number of fields along with synthetic approaches. Moreover, despite versatile contributions, the applicable potential of SNPs is still a tip of the iceberg waiting to be exploited more, hence, the last section of the review presents the future prospects containing only few of the many gaps/research extensions regarding SNPs that need to be addressed in future work.

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Section: Agricultural Applications Of Snpsmentioning

confidence: 99%

A Comprehensive Review of Synthesis, Applications and Future Prospects for Silica Nanoparticles (SNPs)

Akhter

Rao

Abbasi

et al. 2022

Silicon

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“…Its main application is as a nonviral vector for DNA transfer in gene therapy, including regenerative medicine [78], AIDS, cancer, and hereditary disorder treatments [79]. It has also been used for transfection and editing of genomes in plants [84,85], as well as for the gene silencing systems mentioned above aimed at disease and pest control [22,47,52,86,87].…”

Section: Polyplex Nanoparticlesmentioning

confidence: 99%

RNAi Crop Protection Advances

Hernández-Soto

Chacón-Cerdas

2021

IJMS

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RNAi technology is a versatile, effective, safe, and eco-friendly alternative for crop protection. There is plenty of evidence of its use through host-induced gene silencing (HIGS) and emerging evidence that spray-induced gene silencing (SIGS) techniques can work as well to control viruses, bacteria, fungi, insects, and nematodes. For SIGS, its most significant challenge is achieving stability and avoiding premature degradation of RNAi in the environment or during its absorption by the target organism. One alternative is encapsulation in liposomes, virus-like particles, polyplex nanoparticles, and bioclay, which can be obtained through the recombinant production of RNAi in vectors, transgenesis, and micro/nanoencapsulation. The materials must be safe, biodegradable, and stable in multiple chemical environments, favoring the controlled release of RNAi. Most of the current research on encapsulated RNAi focuses primarily on oral delivery to control insects by silencing essential genes. The regulation of RNAi technology focuses on risk assessment using different approaches; however, this technology has positive economic, environmental, and human health implications for its use in agriculture. The emergence of alternatives combining RNAi gene silencing with the induction of resistance in crops by elicitation and metabolic control is expected, as well as multiple silencing and biotechnological optimization of its large-scale production.

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“…Another oligonucleotide of interest for therapeutic applications is plasmid DNA (pDNA) delivery. Since pDNA is typically circular and thus contains no terminal end to serve as a conjugation handle, the most common delivery methods rely on either cationic moieties [62,70,71] or encapsulation. [72,73] However, Beals et al demonstrated a strategy for plasmid delivery by incorporating a biotin group into the sequence of an EGFP plasmid for covalent conjugation to streptavidin-functionalized gold nanoparticles.…”

Section: Oligonucleotide Attachmentmentioning

confidence: 99%

Nanomaterial Strategies for Delivery of Therapeutic Cargoes

Ledesma

Ozcan

Sun

et al. 2021

Adv Funct Materials

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Over the last decade, much progress has been made in developing nanoparticle-mediated delivery systems to overcome the limitations of existing in vivo delivery technologies. However, the balance between efficacy and safety continues to limit the clinical translation of nanoscale delivery systems. Furthermore, optimizing delivery efficiency requires tuning nanoparticle type and attachment chemistry, both of which are dependent on the cargo being delivered. While the delivery of protein therapeutics is of particular interest, the complexity inherent to protein cargo introduces additional challenges for cargo loading and stabilization. Advances needed for efficient and safe in vivo nanoparticle delivery systems should prioritize design strategies that co-optimize safety, biodegradability, and covalent functionalization. In this review, the most commonly used non-viral nanoparticles are outlined for delivery of small molecule drug, nucleic acid, and protein therapeutic cargoes and potential strategies are discussed for rationally designing nanoparticle-mediated delivery systems.

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Ultrasound-mediated gene delivery into suspended plant cells using polyethyleneimine-coated mesoporous silica nanoparticles

Abstract: Graphical abstract

Cited by 33 publications

References 60 publications

A Comprehensive Review of Synthesis, Applications and Future Prospects for Silica Nanoparticles (SNPs)

A Comprehensive Review of Synthesis, Applications and Future Prospects for Silica Nanoparticles (SNPs)

RNAi Crop Protection Advances

Nanomaterial Strategies for Delivery of Therapeutic Cargoes

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