Ultrasound Measures of Brain Pulsatility Correlate with Subcortical Brain Volumes in Healthy Young Adults

Desmidt, Thomas; Andersson, Frédéric; Brizard, Bruno; Dujardin, Paul‐Armand; Cottier, Jean‐Philippe; Patat, F.; Remeniéras, Jean-Pierre; Gissot, Valérie; El‐Hage, Wissam; Camus, Vincent

doi:10.1016/j.ultrasmedbio.2018.06.016

Cited by 13 publications

(25 citation statements)

References 25 publications

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“…The remaining 10 relevant records comprised nine peer-reviewed original publications [11][12][13][14][15][16][17][18][19] and one conference proceeding. 20 The conference proceeding on 2D speckle tracking was included as we found no associated peer-reviewed article.…”

Section: Resultsmentioning

confidence: 99%

“…TPI was used to estimate tissue pulsatility in 25 healthy, middle-aged females. 18 They found a positive correlation between brain pulsatility and the volume of subcortical structures measured using T1 weighted MRI. 18 This study also used a conventional transcranial Doppler pulsatility index (TCD-PI).…”

Section: Summary Of Studiesmentioning

confidence: 94%

“…Quality assessment scores for the 10 records ranged from 6/15 for the conference proceeding 20 to 14/15. 15,16,18 Eight of the records scored over 10 points, which suggests that the majority of studies were of high quality. Appendix 2 summarises the quality assessment for each paper.…”

Section: Study Qualitymentioning

confidence: 99%

“…In the literature, tissue pulsatility imaging (TPI) was the most common method of acquiring brain displacement estimates. [11][12][13][14][15][16]18 TPI extends existing Dopplerbased echocardiography techniques (used clinically for imaging cardiac motion) to the investigation of brain tissue motion. This uses the same phased-array transducer used in echocardiography to estimate displacement of tissue in the direction of the ultrasound beam within a 2D slice of brain tissue.…”

Section: Summary Of Studiesmentioning

confidence: 99%

“…This study of 39 subjects found that pulsatility decreased with age and was positively correlated with fluid intelligence (such as novel problem solving) measures. 17 The latest TPI study was in 2018; Desmidt et al 18 assessed the association between different brain volumes (measured by MRI) and brain pulsatility. TPI was used to estimate tissue pulsatility in 25 healthy, middle-aged females.…”

Section: Summary Of Studiesmentioning

confidence: 99%

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Ultrasound measurement of brain tissue movement in humans: A systematic review

et al. 2019

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Introduction It has long been suggested that ultrasound could be used to measure brain tissue pulsations in humans, but potential clinical applications are relatively unexplored. The aim of this systematic review was to explore and synthesise available literature on ultrasound measurement of brain tissue motion in humans. Methods Our systematic review was designed to include predefined study selection criteria, quality evaluation, and a data extraction pro-forma, registered prospectively on PROSPERO (CRD42018114117). The systematic review was conducted by two independent reviewers. Results Ten studies were eligible for the evidence synthesis and qualitative evaluation. All eligible studies confirmed that brain tissue motion over the cardiac cycle could be measured using ultrasound; however, data acquisition, analysis, and outcomes varied. The majority of studies used tissue pulsatility imaging, with the right temporal window as the acquisition point. Currently available literature is largely exploratory, with measurements of brain tissue displacement over a narrow range of health conditions and ages. Explored health conditions include orthostatic hypotension and depression. Conclusion Further studies are needed to assess variability in brain tissue motion estimates across larger cohorts of healthy subjects and in patients with various medical conditions. This would be important for informing sample size estimates to ensure future studies are appropriately powered. Future research would also benefit from a consistent framework for data analysis and reporting, to facilitate comparative research and meta-analysis. Following standardisation and further healthy participant studies, future work should focus on assessing the clinical utility of brain tissue pulsation measurements in cerebrovascular disease states.

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Section: Resultsmentioning

confidence: 99%

Section: Summary Of Studiesmentioning

confidence: 94%

Section: Study Qualitymentioning

confidence: 99%

Section: Summary Of Studiesmentioning

confidence: 99%

Section: Summary Of Studiesmentioning

confidence: 99%

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Ultrasound measurement of brain tissue movement in humans: A systematic review

et al. 2019

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Informatics Technologies in the Diagnosis and Treatment of Mental Health Conditions

Ingram¹,

Khanna²,

Weston³

2021

Health Informatics

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Magnetic resonance imaging of the pulsing brain: a systematic review

Almudayni

Alharbi

Chowdhury

et al. 2022

Magn Reson Mater Phy

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Objective To perform a systematic review of the literature exploring magnetic resonance imaging (MRI) methods for measuring natural brain tissue pulsations (BTPs) in humans. Methods A prospective systematic search of MEDLINE, SCOPUS and OpenGrey databases was conducted by two independent reviewers using a pre-determined strategy. The search focused on identifying reported measurements of naturally occurring BTP motion in humans. Studies involving non-human participants, MRI in combination with other modalities, MRI during invasive procedures and MRI studies involving externally applied tests were excluded. Data from the retrieved records were combined to create Forest plots comparing brain tissue displacement between Chiari-malformation type 1 (CM-I) patients and healthy controls using an independent samples t-test. Results The search retrieved 22 eligible articles. Articles described 5 main MRI techniques for visualisation or quantification of intrinsic brain motion. MRI techniques generally agreed that the amplitude of BTPs varies regionally from 0.04 mm to ~ 0.80 mm, with larger tissue displacements occurring closer to the centre and base of the brain compared to peripheral regions. Studies of brain pathology using MRI BTP measurements are currently limited to tumour characterisation, idiopathic intracranial hypertension (IIH), and CM-I. A pooled analysis confirmed that displacement of tissue in the cerebellar tonsillar region of CM-I patients was + 0.31 mm [95% CI 0.23, 0.38, p < 0.0001] higher than in healthy controls. Discussion MRI techniques used for measurements of brain motion are at an early stage of development with high heterogeneity across the methods used. Further work is required to provide normative data to support systematic BTPs characterisation in health and disease.

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Ultrasound Measures of Brain Pulsatility Correlate with Subcortical Brain Volumes in Healthy Young Adults

Cited by 13 publications

References 25 publications

Ultrasound measurement of brain tissue movement in humans: A systematic review

Ultrasound measurement of brain tissue movement in humans: A systematic review

Informatics Technologies in the Diagnosis and Treatment of Mental Health Conditions

Magnetic resonance imaging of the pulsing brain: a systematic review

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