Ultrasound measurement of optic nerve sheath diameter in a healthy adult Colombian population

Abstract

Background Measurement of the optic nerve sheath diameter (ONSD) provides a rapid, safe, and easy method for detecting increased intracranial pressure (ICP). However, the normal mean and upper limit values may vary according to sex, age, ethnicity, and ultrasound technique. Aim We aimed to obtain the mean ONSD in a healthy Colombian adult population and to correlate it with demographic and anthropometric measures. Methods In a prospective study using a 10–13 MHz linear ultrasound probe, eye transverse diameter (ETD) and ONSD in the transverse (ONSD-TP) and sagittal planes (ONSD-SP) were measured in healthy adult volunteers in Bogota, Colombia. Results A total of 100 healthy subjects were included, with a mean age of 26,7 ± 8,3 years and 62 women. The mean ETD, ONSD-TP and ONSD-SP was 23.11 mm (95% confidence interval (CI): 22.90 mm-23.32 mm), 3.96 mm (95% CI: 3.85 mm-4.07 mm) and 4.0 mm (95% CI: 3.90 mm-4.11 mm), respectively. The ONSD in both planes ranged from 2.35 mm to 5.20 mm. There was a significant correlation between ONSD-SP and ONSD-TP (p < 0.0001) but no correlation between the ocular measures and demographic or anthropometric variables (p > 0.05). The intraclass correlation between the eyes was statistically significant. Conclusion Our study shows that ultrasound-measured ONSD in healthy adults in Colombia is similar to that found worldwide. An ONSD of 5.5 mm may be considered the upper limit for healthy adults in Colombia. ONSD can be measured in either plane; there is a good correlation between the two eyes; and ONSD is not modified by demographic or anthropometric characteristics.

Frequency of idiopathic intracranial hypertension with ultrasound in patients with fibromyalgia: Relation with function, central sensitization, and neuropathic pain

“…have been established for this routinely applied method. 15,23 In our study, when compared with healthy volunteers, the FMS patient group showed a significant increase in the ONSD, an indicator 24,25 In another study, it is suggested that benign intracranial hypertension-IIH, FMS, and ME/CFS might share a common pathophysiology, leading to overlapping symptoms such as increased intracranial pressure-related headaches, fatigue, and cognitive impairment. 5 Studies conducted in IIH and FMS indicate reduced olfactory bulb volume and impaired function, along with overlapping symptoms like sicca symptoms and increased vertigo frequency.…”

“…It has been shown that ultrasonographic measurement of the ONSD from the eyeball can produce results as well as MRI in diagnosing IHH. Standard application techniques and 5.5 mm diameter cut‐off value have been established for this routinely applied method 15,23 …”

Using Optic Nerve Sheath Diameter for Intracranial Pressure (ICP) Monitoring in Traumatic Brain Injury: A Scoping Review

“…Some of these methods demonstrated better correlation with ICPi and even greater sensitivity and specificity than ONSD alone [ 18 , 19 ]. Such methods may represent an attempt to individualize ONSD measurements by taking into account eyeball size and its relation to ONSD for each patient [ 19 ]; however, there are also recently published data that contrarily report no correlation between global size and ONSD in a healthy Latin American population, creating possible uncertainties regarding the usefulness of these techniques for nICP assessment [ 42 ]. On the other hand, these methods may constitute a sonographic assessment of optic disk changes, which may be detected earlier than changes in routine fundoscopy, specifically papilledema [ 18 , 43 ].…”