Ultrasound malignancy risk stratification of thyroid nodules based on the degree of hypoechogenicity and echotexture

Lee, Ji Ye; Na, Dong Gyu; Yoon, So Jin; Gwon, Hye Yun; Paik, Wooyul; Kim, Tae‐Eun; Kim, Jin Yub

doi:10.1007/s00330-019-06527-8

Cited by 30 publications

(48 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypoechogenicity showed fair diagnostic performance in our review (AUC = 0.8092). A previous study ( 32 ) that subdivided TNs based on their degree of hypoechogenicity also found that TNs with marked or moderate hypoehcogenicity had significantly higher malignant risks than mild hypoechogenicity (p < 0.001). This feature related closely with malignancy from the perspective of pathology.…”

Section: Discussionmentioning

confidence: 70%

Diagnostic Value of Sonographic Features in Distinguishing Malignant Partially Cystic Thyroid Nodules: A Systematic Review and Meta-Analysis

et al. 2021

View full text Add to dashboard Cite

Ultrasonography (US) is one of the most important methods for the management of thyroid nodules, which can be classified as solid, partially cystic, or cystic by composition. The various Thyroid Imaging Reporting and Data System classifications pay more attention to solid nodules and have reported pertinent US features associated with malignancy. However, the likelihood of malignancy of partially cystic thyroid nodules (PCTNs) is 3.3–17.6%, and few studies have systematically discussed the value of US in differentiating such entities. Therefore, we deemed it necessary to perform a systematic evaluation of US features in recognizing malignant PCTNs. Our systematic review and meta-analysis aimed to assess the value of US features in predicting malignant PCTNs. We searched the PubMed/MEDLINE, Web of Science, and Cochrane Library databases to find studies that researched US features of PCTNs and that were published before June 2020. Review Manager 5.3 was used to summarize suspicious US features and calculate the sensitivity, specificity, and likelihood ratios. MetaDiSc 1.4 was used to estimate receiver operating characteristic curves and calculate areas under the curves (AUCs). Our review included eight studies with a total of 2,004 PCTNs. Seven features were considered to be associated with malignancy. High specificity (>0.9) was found in nodules with a taller-than-wide shape, those that were spiculated/microlobulated or with an ill-defined margin, those with microcalcification, and a non-smooth rim. Among US features, eccentric configuration, microcalcification, and marked or mild hypoechogenicity were more reliable in predicting malignancy (AUC: 0.9592, 0.8504, and 0.8092, respectively). After meta-analysis, we recommend combining PCTN US features including an eccentric internal solid portion, marked or mild hypoechogenicity, and presence of microcalcification to better identify malignant nodules. More studies are needed to explore and improve the diagnostic value of US in PCTNs.

show abstract

Section: Discussionmentioning

confidence: 70%

Diagnostic Value of Sonographic Features in Distinguishing Malignant Partially Cystic Thyroid Nodules: A Systematic Review and Meta-Analysis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Heterogeneous predominantly hypoechoic nodules showed a significantly higher malignancy risk than predominantly iso-or hyperechoic thyroid nodules. There were no significant differences of malignancy risk between heterogeneous predominantly hypoechoic and homogeneous hypoechoic nodules according to the degree of hypoechogenicity and between heterogeneous predominantly iso-or hyperechoic nodules and homogeneous iso-or hyperechoic nodules [8].…”

mentioning

confidence: 69%

Imaging, biopsy and non-surgical treatment of thyroid lesions: where are we at?

Lavoipierre¹

2020

Eur Radiol

View full text Add to dashboard Cite

show abstract

“…Echogenicity: the EU-TIRADS considers that even a small hypoechoic part is sufficient to classify the nodule as hypoechoic, whereas K-TIRADS and ACR-TIRADS define the echogenicity of the nodule by its predominant one in heterogeneous nodules. The correctness of the definition of the K-TIRADSs seems to have been confirmed in a report on 2255 nodules, with a retrospective design [25]. Finally, the term markedly hypoechoic applies in the K-TIRADS as more or of equivalent hypoechogenicity to the strap muscles and in the other systems only as more hypoechoic than strap muscles.…”

Section: Lexiconmentioning

confidence: 82%

The New Era of TIRADSs to Stratify the Risk of Malignancy of Thyroid Nodules: Strengths, Weaknesses and Pitfalls

Russ

Trimboli

Buffet

2021

Cancers

View full text Add to dashboard Cite

Since 2009, thyroid imaging reporting and data systems (TI-RADS) have been playing an increasing role in the field of thyroid nodules (TN) imaging. Their common aims are to provide sonologists of varied medical specialties and clinicians with an ultrasound (US) based malignancy risk stratification score and to guide decision making of fine-needle aspiration (FNA). Schematically, all TI-RADSs scores can be classified as either pattern-based or point-based approaches. The main strengths of these systems are their ability (i) to homogenize US TN descriptions among operators, (ii) to facilitate and shorten communication on the malignancy risk of TN between sonologists and clinicians, (iii) to provide quantitative ranges of malignancy risk assessment with high sensitivity and negative predictive values, and (iv) to reduce the number of unnecessary FNAs. Their weaknesses are (i) the remaining inter-observer discrepancies and (ii) their insufficient sensitivity for the diagnosis of follicular cancers and follicular variant of papillary cancers. Most common pitfalls are degenerating shrinking nodules and confusion between individual and coalescent nodules. The benefits of all TI-RADSs far outweigh their shortcomings, explaining their rising use, but the necessity to improve and merge the different existing systems remains.

show abstract

Ultrasound malignancy risk stratification of thyroid nodules based on the degree of hypoechogenicity and echotexture

Cited by 30 publications

References 25 publications

Diagnostic Value of Sonographic Features in Distinguishing Malignant Partially Cystic Thyroid Nodules: A Systematic Review and Meta-Analysis

Diagnostic Value of Sonographic Features in Distinguishing Malignant Partially Cystic Thyroid Nodules: A Systematic Review and Meta-Analysis

Imaging, biopsy and non-surgical treatment of thyroid lesions: where are we at?

The New Era of TIRADSs to Stratify the Risk of Malignancy of Thyroid Nodules: Strengths, Weaknesses and Pitfalls

Contact Info

Product

Resources

About