Ultrasound, liposomes, and drug delivery: principles for using ultrasound to control the release of drugs from liposomes

Sonosensitive dioleoylphosphatidylethanolamine-containing liposomes with prolonged blood circulation time of doxorubicin

“…Local application of US to tumours produces several effects, such as enhancing extravasation of liposomes to tumours, inducing drug leakage from the liposome carrier and enhancing cell membrane permeability with a resulting increased intracellular drug uptake (For recent reviews see Schroeder et al, 2009;Pitt et al, 2004;Frenkel, 2008). In order to maximize the therapeutic efficacy, liposomes should display properties that both impart high US sensitivity (sonosensitivity) and favour drug retention in the blood stream, to enable sufficient tumour accumulation.…”

“…Recently, there has been increasing interest in using ultrasound (US) as a means to physically and non-invasively trigger drug release from liposomes upon accumulation in tumour tissue (de Smet et al, 2010;Schroeder et al, 2009;Myhr and Moan, 2006;Pong et al, 2006). Local application of US to tumours produces several effects, such as enhancing extravasation of liposomes to tumours, inducing drug leakage from the liposome carrier and enhancing cell membrane permeability with a resulting increased intracellular drug uptake (For recent reviews see Schroeder et al, 2009;Pitt et al, 2004;Frenkel, 2008).…”

Dissolution Behavior, Stability and Anti-Inflammatory Activity of Ketoprofen Coated Tripolyphosphate Modified Chitosan Nanoparticle

“…Ultrasonication principles closely linked to the acoustic cavitation phenomenon, the formation, growth, and rupture of bubbles formed in the liquid medium [1]. When the ultrasonic wave propagates in a liquid medium strain and density cycles occur, bubbles formed will absorb energy and ultrasonic waved, so the bubble will expand to its maximum size and eventually rupture [2].…”

“…Sonochemistry principle is closely linked to the acoustic cavitation phenomenon which is the formation, growth, and rupture of bubbles formed in the liquid medium [1]. On this cavitation phenomenon, the ultrasonic sound that propagates in the liquid medium has the ability to generate a bubble or cavity in a liquid medium.…”

“…The decrease of pressure resulted in a strain that form a bubble will absorb energy from ultrasonic waves, so the bubble can expand to a maximum size and eventually rupture [2]. According to Schroeder et al [1] bubble burst resulted extreme conditions which include temperature rising, reaches 5000 K and pressures increasing up to 1000 atm with heating to cooling speed reached >10 10 K/s. These extreme conditions cause the termination of the chemical bond, called as the Hot Spot Theory.…”