Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm

Kutty, Shelby; Liu, Na; Zhou, Jia; Xiao, Yunbin; Wu, Juefei; Danford, David A.; Lof, John; Xie, Feng; Porter, Thomas R.

doi:10.1016/j.jacbts.2017.07.011

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…The mechanical effect of FUS attracted more interest in recent years for histotripsy, thrombolysis and sonodynamic therapy [32]. Ultrasound-induced cavitation is a promising and fast technology for induction of necrosis [33], reduction of localized fat [34], support drug/gene delivery [35], applied for thrombolysis [36] and opening of the BBB [37]. Even cavitation demonstrated good potential in cancer therapy, the effect of the combination of cavitation and other therapies was not sufficiently investigated and the underlying mechanisms remain unclear.…”

Section: Discussionmentioning

confidence: 99%

Focused Ultrasound-Induced Cavitation Sensitizes Cancer Cells to Radiation Therapy and Hyperthermia

Zhang

Unger

et al. 2020

Cells

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Focused ultrasound (FUS) has become an important non-invasive therapy for solid tumor ablation via thermal effects. The cavitation effect induced by FUS is thereby avoided but applied for lithotripsy, support drug delivery and the induction of blood vessel destruction for cancer therapy. In this study, head and neck cancer (FaDu), glioblastoma (T98G), and prostate cancer (PC-3) cells were exposed to FUS by using an in vitro FUS system followed by single-dose X-ray radiation therapy (RT) or water bath hyperthermia (HT). Sensitization effects of short FUS shots with cavitation (FUS-Cav) or without cavitation (FUS) to RT or HT (45 °C, 30 min) were evaluated. FUS-Cav significantly increases the sensitivity of cancer cells to RT and HT by reducing long-term clonogenic survival, short-term cell metabolic activity, cell invasion, and induction of sonoporation. Our results demonstrated that short FUS treatment with cavitation has good potential to sensitize cancer cells to RT and HT non-invasively.

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Section: Discussionmentioning

confidence: 99%

Focused Ultrasound-Induced Cavitation Sensitizes Cancer Cells to Radiation Therapy and Hyperthermia

Zhang

Unger

et al. 2020

Cells

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“…The effects of microbubble-enhanced sonothrombolysis in boosting endothelial nitric oxide release for restoration of peripheral flow due to catheter-induced vasospasm (CIV) were studied by Kutty and colleagues in a porcine model [68]. A total of 24 randomized CIV treatments were performed in 16 pigs of unknown ages.…”

Section: Vascular and Cardiovascular Conditionsmentioning

confidence: 99%

“…Children with congenital heart diseases often undergo multiple cardiac and vascular catheterizations and, at their baseline, hold a higher risk for CIV and thrombosis. Moreover, infants demonstrate an increased risk of thromboembolism, with up to 20% of thrombi occurring in the femoral vessels, likely in part due to small body size [68]. Despite advances in technology, arterial injury and thromboembolic events in critically ill catheterized children continue to be associated with high mortality and morbidity rates, with one autopsy study reporting umbilical venous catheter (UVC) thromboembolic events in 20 to 65% of neonates with a UVC in place at the time of demise [96][97][98][99].…”

Section: Vascular and Cardiovascular Conditionsmentioning

confidence: 99%

Sonothrombolysis: State-of-the-Art and Potential Applications in Children

Ward,

Martinez-Correa,

Tierradentro-García

et al. 2023

Children

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In recent years, advances in ultrasound therapeutics have been implemented into treatment algorithms for the adult population; however, the use of therapeutic ultrasound in the pediatric population still needs to be further elucidated. In order to better characterize the utilization and practicality of sonothrombolysis in the juvenile population, the authors conducted a literature review of current pediatric research in therapeutic ultrasound. The PubMed database was used to search for all clinical and preclinical studies detailing the use and applications of sonothrombolysis, with a focus on the pediatric population. As illustrated by various review articles, case studies, and original research, sonothrombolysis demonstrates efficacy and safety in clot dissolution in vitro and in animal studies, particularly when combined with microbubbles, with potential applications in conditions such as deep venous thrombosis, peripheral vascular disease, ischemic stroke, myocardial infarction, and pulmonary embolism. Although there is limited literature on the use of therapeutic ultrasound in children, mainly due to the lower prevalence of thrombotic events, sonothrombolysis shows potential as a noninvasive thrombolytic treatment. However, more pediatric sonothrombolysis research needs to be conducted to quantify the safety and ethical considerations specific to this vulnerable population.

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“…In the medical field, therapeutic methods such as drug / gene delivery and cancer cell growth inhibition using ultrasound and fine bubble cavitation have been investigated (Huang Supporting information Additional supporting information may be found online in the Supporting Information section at the end of the article. Kutty et al, 2017;Shen et al, 2018;Unger et al, 2001). In the environment and energy fields, fine bubble-related research include the purification of groundwater with ozone (Hu and Xia, 2018) and of wastewater containing phenol using free radicals (Li et al, 2009b) and diethyl phthalate (Jabesa and Ghosh, 2016), and from acrylic fiber manufacturing plants (Zheng et al, 2015),.…”

Section: Introductionmentioning

confidence: 99%

Effect of Fine Bubbles on Removal of Linear Alkyl Benzene Sulfonate Surfactant during the Rinsing Stage of Laundry Washing

Oya

2020

J Surfact & Detergents

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The use of fine bubbles is a promising approach to remove surfactant efficiently during the rinsing process of clothing, to fulfill a requirement. Therefore, the influence of fine bubbles on the removal performance of surfactant from cloth during the rinse process of pulsator washing machine (top loading type) was investigated. The test apparatus was assembled by connecting a microbubble generation tank and a small washing machine with tubes and circulating fine bubble water to a small washing machine. Swatches of cloth with a specified amount of linear alkylbenzene sulfonate (LAS) adsorbed from aqueous solution, were rinsed with tap water, and the LAS concentration in the rinse water was examined with an HPLC system equipped with a high‐precision fluorescence detector. The average bubble diameter of the fine bubble water used was 0.13–1.4 μm. In the rinsing experiment, no difference was found in the final LAS removal efficiency between water with and without bubbles; but the former increased the LAS removal rate during the initial stage of rinsing. This tendency was particularly noticeable when the stirring power of the washing machine was weak. Therefore, it was concluded that the fine bubble effect on the removal of the surfactant is mainly a kinetic effect rather than an equilibrium effect.

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Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm

Abstract: Visual Abstract

Cited by 7 publications

References 31 publications

Focused Ultrasound-Induced Cavitation Sensitizes Cancer Cells to Radiation Therapy and Hyperthermia

Focused Ultrasound-Induced Cavitation Sensitizes Cancer Cells to Radiation Therapy and Hyperthermia

Sonothrombolysis: State-of-the-Art and Potential Applications in Children

Effect of Fine Bubbles on Removal of Linear Alkyl Benzene Sulfonate Surfactant during the Rinsing Stage of Laundry Washing

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