Ultrasound-induced acoustophoretic motion of microparticles in three dimensions

Müller, Peter; Rossi, Massimiliano; Marin, Alvaro; Barnkob, Rune; Augustsson, Per; Laurell, Thomas; Kähler, Christian J.; Bruus, Henrik

doi:10.1103/physreve.88.023006

Cited by 153 publications

(174 citation statements)

References 45 publications

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“…By actuating the transducer at a resonance frequency of the cavity, an acoustic standing-wave field can be established in the channel cross section in the y-z plane, which is typically a few hundred micrometers in the width W and height H, leading to fundamental resonance frequencies on the order of 1-10 MHz. These systems are well characterized [4,[25][26][27][28] and are used in various biomedical applications, for example, the enrichment of circulating tumor cells in blood [14,29].…”

Section: Model Systemsmentioning

confidence: 99%

Acoustic Tweezing and Patterning of Concentration Fields in Microfluidics

Karlsen

Bruus

2017

Phys. Rev. Applied

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We demonstrate theoretically that acoustic forces acting on inhomogeneous fluids can be used to pattern and manipulate solute concentration fields into spatiotemporally controllable configurations stabilized against gravity. A theoretical framework describing the dynamics of concentration fields that weakly perturb the fluid density and speed of sound is presented and applied to study manipulation of concentration fields in rectangular-channel acoustic eigenmodes and in Bessel-function acoustic vortices. In the first example, methods to obtain horizontal and vertical multilayer stratification of the concentration field at the end of a flow-through channel are presented. In the second example, we demonstrate acoustic tweezing and spatiotemporal manipulation of a local high-concentration region in a lower-concentration medium, thereby extending the realm of acoustic tweezing to include concentration fields.

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Section: Model Systemsmentioning

confidence: 99%

Acoustic Tweezing and Patterning of Concentration Fields in Microfluidics

Karlsen

Bruus

2017

Phys. Rev. Applied

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“…The phenomenon of acoustic streaming was first described theoretically by Lord Rayleigh [4] in 1884, and has later been revisited, among others, by Schlicting [5], Nyborg [6], Hamilton [7,8], Rednikov and Sadhal [9], and Muller et al [10], to extend the fundamental treatment of the governing equations and to solve the equations for various open and closed geometries.…”

Section: Introductionmentioning

confidence: 99%

Theoretical study of time-dependent, ultrasound-induced acoustic streaming in microchannels

Müller

Bruus

2015

Phys. Rev. E

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Based on first-and second-order perturbation theory, we present a numerical study of the temporal buildup and decay of unsteady acoustic fields and acoustic streaming flows actuated by vibrating walls in the transverse cross-sectional plane of a long straight microchannel under adiabatic conditions and assuming temperatureindependent material parameters. The unsteady streaming flow is obtained by averaging the time-dependent velocity field over one oscillation period, and as time increases, it is shown to converge towards the well-known steady time-averaged solution calculated in the frequency domain. Scaling analysis reveals that the acoustic resonance builds up much faster than the acoustic streaming, implying that the radiation force may dominate over the drag force from streaming even for small particles. However, our numerical time-dependent analysis indicates that pulsed actuation does not reduce streaming significantly due to its slow decay. Our analysis also shows that for an acoustic resonance with a quality factor Q, the amplitude of the oscillating second-order velocity component is Q times larger than the usual second-order steady time-averaged velocity component. Consequently, the well-known criterion v 1 c s for the validity of the perturbation expansion is replaced by the more restrictive criterion v 1 c s /Q. Our numerical model is available as supplemental material in the form of COMSOL model files and MATLAB scripts.

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“…The tracking of particle motion under ASWs using the astigmatism particle tracking velocity (APTV) technique was also reported by Muller et al [18]. In this paper, the 3D positions of particles in the flow were calculated through the numerical reconstruction of holograms record- [19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional matrixlike focusing of microparticles in flow through minichannel using acoustic standing waves: An experimental and modeling study

Perfetti

Iorio

2016

Acoust. Sci. & Tech.

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In this work, we demonstrate the possibility of focusing a stream of microparticles to generate a matrixlike distribution using bulk acoustic standing waves. To achieve this goal, an axial acoustic excitation was performed on a suspension of spherical quasi-monodisperse microparticles in a flow through minichannel with a square cross section of 2 mm Â 2 mm. The pair of transducer elements was also used for stimulation at several frequencies corresponding to its theoretical eigenmodes. The generation of the matrixlike tree-dimensional (3D) structures of focused particles was achieved by reflections of the acoustic radiation force associated with the square geometry. Particle positions were recorded by interferometric digital holographic microscopy, and the corresponding normalized distribution in the cross section was calculated for each experimental setting. The focusing efficiency was investigated through the variation of the acoustic energy density induced by the voltage applied to the piezo part and the injected flow rate. The acoustic field was numerically computed and compared with the experimental positions of particles in the cross section of the channel.

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Ultrasound-induced acoustophoretic motion of microparticles in three dimensions

Cited by 153 publications

References 45 publications

Acoustic Tweezing and Patterning of Concentration Fields in Microfluidics

Acoustic Tweezing and Patterning of Concentration Fields in Microfluidics

Theoretical study of time-dependent, ultrasound-induced acoustic streaming in microchannels

Three-dimensional matrixlike focusing of microparticles in flow through minichannel using acoustic standing waves: An experimental and modeling study

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