Ultrasound in the diagnosis and monitoring of eosinophilic fasciitis

Eong, Denise T M Au; Cronin, Owen; Biswas, Asok; McKay, Neil

doi:10.1093/rheumatology/keaa498

Cited by 7 publications

(12 citation statements)

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“…The medium-resolution US (7-15MHz) has been employed to monitor disease activity in EF patients, 24,28,29 but no specific and globally accepted protocol for lesional skin examination exists. 11 To the best of our knowledge, examinations with There is currently no universally accepted protocol for treating EF: systemic corticosteroids and immunosuppressants induce remission of disease in many cases and are effective on articular symptoms as pain and stiffness 21 but do not impact significantly over the dermal and hypodermal rigidities. 2,3,21 The core rationale for delivering UVA-1 phototherapy in sclerotic skin diseases, observed in in vitro experiments in the last decade, includes the modulation of proinflammatory cytokines, the stimulation of the interstitial matrix metalloproteinases, and the induction of apoptosis of T cells in the superficial dermis.…”

Section: Commentmentioning

confidence: 99%

“…The medium‐resolution US (7–15MHz) has been employed to monitor disease activity in EF patients, 24,28,29 but no specific and globally accepted protocol for lesional skin examination exists 11 . To the best of our knowledge, examinations with HRUS (22 MHz) and uHRUS (50 MHz) were never reported in EF patients.…”

Section: Commentmentioning

confidence: 99%

“…UVA‐1 phototherapy was employed in many sclerosing diseases of the skin in the last decades, but there are few recent reports as an adjuvant treatment also in EF 9,10 . As per disease monitoring, there are some experiences with medium resolution ultrasound (US) only 8,11 …”

Section: Introductionmentioning

confidence: 99%

“…9,10 As per disease monitoring, there are some experiences with medium resolution ultrasound (US) only. 8,11 We first aimed to obtain a thorough clinical-functional characterization of EF patients undergoing an adjuvant UVA therapy, using high-resolution US, second, to evaluate the response to UVA-1 irradiation in vitro of human fibroblast primary cultures from lesional skin, and third, to investigate the gene expression profiling of both profibrotic and antifibrotic pathways before and after in vivo UVA-1 irradiation.…”

Section: Introductionmentioning

confidence: 99%

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UVA‐1 phototherapy as adjuvant treatment for eosinophilic fasciitis: in vitro and in vivo functional characterization

et al. 2021

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Introduction Eosinophilic fasciitis (EF) is a rare autoimmune disease causing progressive induration of dermal, hypodermal, and muscularis fascia. The exact pathogenesis is yet to be fully understood, and a validated therapy protocol still lacks. We here aimed to realize a clinical-functional characterization of these patients.Materials and methods A total of eight patients (five males, 45 years average) were treated with adjuvant high-dose UVA-1 phototherapy (90 J/cm), after having received the standard systemic immunosuppressive protocol (oral methylprednisolone switched to methotrexate). Body lesion mapping, Localized Scleroderma Assessment Tool (LoSCAT), Dermatology Life Quality Index (DLQI), High-Resolution Ultrasound (HRUS) (13-17MHz), and ultra HRUS (55-70 MHz) were performed at each examination time taking specific anatomical points. Gene expression analysis at a molecular level and in vitro UVA-1 irradiation was realized on lesional fibroblasts primary cultures. ResultsThe LoSCAT and the DLQI showed to decrease significantly starting from the last UVA-1 session. A significant reduction in muscularis fascia thickness (À50% on average) was estimated starting from 3 months after the last UVA-1 session and maintained up to 12 months follow-up. Tissues was detected by HRUS. The UVA-1 in vitro irradiation of lesional skin sites cells appeared not to affect their viability. Molecular genes analysis revealed a significant reduction of IL-1ß and of TGF-ß genes after phototherapy, while MMPs 1,2,9 gene expression was enhanced.Comment These preliminary in vivo and in vitro findings suggest that UVA-1 phototherapy is a safe and useful adjuvant therapy able to elicit anti-inflammatory effects and stimulate tissue matrix digestion and remodeling at lesional sites.

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Section: Commentmentioning

confidence: 99%

Section: Commentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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UVA‐1 phototherapy as adjuvant treatment for eosinophilic fasciitis: in vitro and in vivo functional characterization

et al. 2021

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“…Отмечено утолщение кожи, подкожножировой клетчатки, сухожилий и фасций, выраженное снижение эластичности и степени сжатия мягких тканей. Во всех случаях результаты УЗИ коррелировали с патологическими изменениями при МРТ [15][16][17].…”

Section: ключевые слова: 18 F-фтордезоксиглюкоза пэт/кт эозинофильный...unclassified