Ultrasound Imaging of the Fetal Palate

Wong, H. S.; Pringle, Kevin C.

doi:10.5772/18306

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…In addition, the type of cleft will also be affected, as highlighted in the study by Sommerlad et al [28]. While the combined use of both tests may improve sensitivity and specificity in detecting cleft lip, the efficacy may be variable in diagnosing hard and soft palate, as 3D ultrasound can be used to determine whether the defect extends to the alveolar or secondary palate, the type and extension of the fissure, and to show whether the cleft involves the soft palate or hard palate [14,31,32].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic Review

Baeza-Pagador,

Tejero-Martínez,

Salom-Alonso

et al. 2024

JCM

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Background: Accurate prenatal diagnosis of cleft lip and palate is essential to discuss severity prediction, perform appropriate parental counseling, and, at last, establish long-term treatment planning. The aim of this systematic review was to analyze the accuracy of various imaging techniques for the prenatal diagnosis of cleft lip and palate, assess the pregnancy phase for orofacial clefts diagnosis, and study the different cleft types in terms of diagnostic methods, timing, and predictability. Methods: A search of the PubMed, EMBASE, Scopus, and Web of Science databases was conducted to identify potentially relevant studies published until January 2024. The quality of the selected articles was assessed using the Newcastle–Ottawa scale for methodological quality assessment of cohort studies and the QUADAS-2 scale for diagnostic test studies. Results: A total of 18 studies met the eligibility criteria and were included in the review. The findings of this review indicate that the majority of studies showed improved diagnostic accuracy when supplementary techniques, such as 3D ultrasound or magnetic resonance imaging, were added to 2D ultrasound. Conclusions: The implementation of magnetic resonance imaging as a standard procedure could significantly improve the precision of diagnosing cleft lip and palate. Therefore, the diagnostic technique used will play a crucial role in the accuracy of the diagnosis.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic Review

Baeza-Pagador,

Tejero-Martínez,

Salom-Alonso

et al. 2024

JCM

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“…The coronal view provides visualization of the nares and upper lip 12 . The midsagittal view captures the hard and soft palate, while the axial view reveals the maxillary alveolar ridge 13 .…”

Section: Subjects and Samplesmentioning

confidence: 99%

Association of prenatal Cleft Lip and Palate ultrasound abnormalities with copy number variants at a single Chinese tertiary center

Yan,

Yu,

Zhou

et al. 2024

Preprint

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Backgroud: A systematic analysis was conducted to investigate the molecular etiology of fetal cleft lip and/or palate (CL/CP) and the association between various types of CL/CP and copy number variations (CNVs), as well as their impact on birth outcomes. Methods:In this retrospective study, a cohort of pregnancies diagnosed with fetal CL/CP was enrolled and comprehensive clinical data for all cases were extracted from our medical record database, including demographic data about the pregnancies, ultrasound findings, results of Chromosomal microarray (CMA), as well as relevant pregnant and perinatal outcomes. Results:Among the 358 cases, 32 clinically significant variants in 29 (8.1%)fetuses with CL/CP were detected by CMA. In 338 singleton pregnancies, the diagnostic yield of CMA in the context of CL/CP fetuses was determined to be 7.7% (26/338). CP-only cases exhibited a relatively higher prevalence of pathogenic/likely pathogenic (P/LP) CNVs at a rate of 25% (3/12), followed by CLP-only cases at 8.0% (23/288). Notably, the CL-only group did not demonstrate any P/LP CNV findings among the examined cases (0/38). The diagnostic rate of clinically significant variants was significantly higher in the non-isolated CL/CP group than in the isolated CL/CP group (11/33, 33.3% vs. 15/305, 4.9%, p<0.001). In twin pregnancies, 3 clinically significant variants (15.0%) were detected in the other 20 twin pregnancies. Conclusions: This study provides powerful evidence supporting the efficacy of CMA as a valuable tool for facilitating the prenatal genetic diagnosis of fetal CL/CP. The presence of CP and CLP in fetal cases demonstrated a relatively higher incidence of P/LP CNVs. Moreover, when these cases were accompanied by additional ultrasound abnormalities, the likelihood of identifying diagnostic CNVs significantly increased. Conversely, cases of CL alone might not be associated with positive CNVs. The present data may significantly enhance prenatal diagnosis accuracy and facilitate informed genetic counseling for individuals affected by fetal CL/CP.

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“…This led to the uvula being targeted as an anatomical landmark to evaluate for isolated clefts of the palate. With the advent of 3D (three dimensional) ultrasound, there has been a definitive improvement in visualization of the secondary palate [5][6][7][8][9][10]. Various 3D techniques have been proposed since 2005 and these techniques attempted to visualise the secondary palate which enhanced the detection of secondary palatine clefts [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Role of TUI in First Trimester Evaluation of Palate

Lakshmy

Rose

Masilamani

et al. 2019

Journal of Fetal Medicine

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The purpose of the study is to report on the application of tomographic ultrasound imaging (TUI) in prenatal sonographic study of fetal palate in 11–14 week scan. TUI is a technology that allows the examiner to obtain a volume data set that allows the display of numerous 2D slices from a given volume on any of the three orthogonal planes. It allows automatic slicing of the volume datasets displaying multiple parallel images. The fetal palate was examined with TUI in thirteen abnormal volumes and in ninety-four normal volumes. The appearance of maxillary line in sagittal sections and the base of the retronasal triangle in coronal sections serve as key landmarks in evaluating palatine clefts. The intact palatal line in sagittal sections was observed in all the ninety-four normal volumes. The midline anatomy of the palate has been described in the study emphasising that the vomer can mimic palate in midsagittal section in secondary palatine clefts. The parasagittal sections truly reflects the presence or absence of the palate without the confounding factor of the vomer bone which was demonstrated in the abnormal volumes with TUI. The potential advantage of TUI in evaluating palate is that it allows the display of both midsagittal and parasagittal sections simultaneously. The different types of cleft have a constant reproducible pattern in TUI imaging which can be used to diagnose palatine clefts including isolated cleft of palate. Prospective studies are needed to confirm these promising results.

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Ultrasound Imaging of the Fetal Palate

Cited by 3 publications

References 21 publications

Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic Review

Diagnostic Methods for the Prenatal Detection of Cleft Lip and Palate: A Systematic Review

Association of prenatal Cleft Lip and Palate ultrasound abnormalities with copy number variants at a single Chinese tertiary center

Role of TUI in First Trimester Evaluation of Palate

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