Ultrasound Imaging of Psoriatic Skin: A Noninvasive Technique to Evaluate Treatment of Psoriasis

Vaillant, L.; Berson, M.; Machet, L.; Callens, A.; Pourcelot, L.; Lorette, G

doi:10.1111/j.1365-4362.1994.tb00994.x

Cited by 64 publications

(60 citation statements)

References 9 publications

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“…However, this sample was sufficient to permit us to closely monitor the temporal improvement in patients treated with two different doses of Cs, which would not have been possible if variability was a problem. Other studies have successfully diagnosed and monitored disease progression using these imaging techniques with similar sample sizes (5,(7)(8)(12)(13)(14)(15)(16)(17)(18)(19)(20). Ideally, a larger sample size would have permitted multivariate analysis to examine in greater detail characteristics contributing to improvement rate.…”

Section: Fig 4 Example Ofa Patient Who Showed Only Partial Improvemmentioning

confidence: 99%

“…In contrast to VD, fewer studies have specifically examined the efficacy of US in monitoring the improvement in plaque psoriasis following pharmacological treatment (18)(19)(20). In one study, 30 psoriatic patients and 10 healthy volunteers treated with clobetasol propionate 0.05% foam either once or twice daily were evaluated using a 20-MHz B-mode high-resolution system.…”

Section: Fig 4 Example Ofa Patient Who Showed Only Partial Improvemmentioning

confidence: 99%

See 1 more Smart Citation

Combined Clinical, Capillaroscopic and Ultrasound Evaluation during Treatment of Plaque Psoriasis with Oral Cyclosporine

Musumeci

Lacarrubba

et al. 2013

Int J Immunopathol Pharmacol

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Imaging techniques have only recently been utilized in combination with clinical observation to objectively quantify psoriasis severity and evaluate therapeutic response. This study evaluated the sensitivity of videodermatoscopy (VO) and ultrasound (US) imaging to assess the therapeutic effect of cyclosporine (Cs) in patients with moderate-to-severe psoriasis. Twenty patients with moderate-tosevere psoriasis were divided into two groups (A and B) based on PASI score. Group A (PASI >16) was treated with 5 mg/Kg/day Cs for 4 weeks and another 4 weeks with 3 mg/Kg/day Cs. Group B (PASI 10-16) received 3 mg/Kg/day Cs for 8 weeks. A "target" plaque was selected for each subject and evaluated using a Target Lesion Score (TLS) for erythema, scaling and degree of infiltration, in addition to VO and US at baseline, 2, 4 and 8 weeks. At the end of the study, improvement rate was quicker in group A vs group B after 8 weeks of Cs therapy. All three parameters (TLS, VO and US) strongly correlated with one another. Skin thickness was the first parameter that improved, followed by TLS. In contrast, improvement in VO was delayed. Normalization rate of vascular pattern (assessed by VO) was low in both groups but higher in group A vs group B (46% vs 22%), despite virtually complete normalization by clinical and US assessment. In conclusion, while both TLS and US can be utilized in the evaluation of therapeutic efficacy in patients with plaque psoriasis, VO can provide information on vascular response to treatment, which may likely affect the duration of therapy and the relapse rates.

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Section: Fig 4 Example Ofa Patient Who Showed Only Partial Improvemmentioning

confidence: 99%

Section: Fig 4 Example Ofa Patient Who Showed Only Partial Improvemmentioning

confidence: 99%

Combined Clinical, Capillaroscopic and Ultrasound Evaluation during Treatment of Plaque Psoriasis with Oral Cyclosporine

Musumeci

Lacarrubba

et al. 2013

Int J Immunopathol Pharmacol

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“…Although not specific for psoriasis, a hypoechoic band in the upper dermis, corresponding to inflammatory edema and vasodilatation, was a commonly observed sonographic feature [23,24] and reported as being a reliable indicator of active stages of the disease. Other inflammatory conditions such as acantoma, atopic dermatitis or contact dermatitis can also present this hypoechoic dermal band [23].…”

Section: Psoriatic Plaquementioning

confidence: 99%

Ultrasonography in psoriatic disease

et al. 2015

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Psoriasis represents a common, chronic inflammatory disease involving the skin, nails and joints. Nail psoriasis in usually investigated and diagnosed by clinical examination. New insights support ultrasonography as being a non-invasive reliable imaging technique for studying nail and skin involvement in patients with psoriasis. Power Doppler frequency, higher than 10MHz enables a very sensitive detection and semiquantitative assessment of the blood flow at the dermal level and in the nail bed. In this review we will present the main US findings in skin and nail psoriasis, and discuss the importance of ultrasonography in diagnosing and monitoring psoriasis vulgaris.

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“…Patients with PND were categorized into two groups by NPT measured by US as NPT <20 mm (n=16) and NPT ≥20 mm (n=18) and the median NAPSI in two groups were 20.5 (12.2-33) and 28.5 (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), respectively (p= 0.05). There were 6 patients in type 1GS changes of psoriatic nails, 6 patients in type 2, 20 patients in type 3, and 2 patients in type 4.…”

Section: Ultrasound Findingsmentioning

confidence: 99%

“…US is also a non-invasive imaging method which allows viewing the anatomical and physiological details of the nails and provides information about the morphological appearance of the nail lesions, together with changes of the underlying tissue and blood flow alteration [22]. During the past decade, several studies have evaluated the usefulness of US for diagnosis, identification of disease activity and follow-up response to treatment in patients with psoriasis [23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

The microvascular and morphostructural changes of nails in psoriatic patients with nail disease; a link between ultrasound and videocapillaroscopy findings in the nailfold

Üreyen¹,

Kara²,

Ertürk³

et al. 2018

Med Ultrason

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Objective: The objective of this study is to evaluate the link between nail fold vessel resistive index (NVRI) measured by ultrasound (US) and capillary loops diameters measured using nailfold videocapillarascopy (NVC), and to assess the morphological appearance of the nail bed in patients with psoriatic nail disease (PND) as compared with healthy controls (HCs).Material and methods: This study was conducted in patients with PND and HCs. General demographic data were collected and clinical assessments were performed for all subjects. The nail plate thickness (NPT) was measured on gray scale using US. The NVRI was measured using color Doppler (CD) US. The measurements of the apical, arterial, venous limb diameters and morpho-structural changes (tortuous, cross-linked capillaries) were assessed using NVC.Results: Thirty-four patients with PND and 15 HCs were enrolled in this study. The two groups were matched for age and body mass index (BMI). Patients with PND had higher NPT and NVRI in comparison with HCs [(20 (17-23) vs 14 (14-15), p<0.001), (0.55 (0.51-0.61) vs 0.43 (0.38-0.49), p<0.001), respectively]. A higher proportion of patients with PND had tortuous capillaries than HCs (62% and 20% respectively, p=0.005). The mean NVRI was higher in patients with PND who had tortuous capillaries than patients who did not have tortuous capillaries (0.58 (0.7) and 0.52 (0.09), respectively p=0.033).Conclusion: Microvascular changes can be detected easily using non-invasive methods such as US and NVC. These methods can provide an objective data to better assess PND.

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Ultrasound Imaging of Psoriatic Skin: A Noninvasive Technique to Evaluate Treatment of Psoriasis

Cited by 64 publications

References 9 publications

Combined Clinical, Capillaroscopic and Ultrasound Evaluation during Treatment of Plaque Psoriasis with Oral Cyclosporine

Combined Clinical, Capillaroscopic and Ultrasound Evaluation during Treatment of Plaque Psoriasis with Oral Cyclosporine

Ultrasonography in psoriatic disease

The microvascular and morphostructural changes of nails in psoriatic patients with nail disease; a link between ultrasound and videocapillaroscopy findings in the nailfold

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