Ultrasound imaging for identification of cerebral damage in congenital Zika virus syndrome: a case series

Schaub, Bruno; Gueneret, M.; Jolivet, E.; Decatrelle, Valérie; Yazza, Soraya; Gueye, H; Monthieux, Alice; Juve, Marie-Laure; Gautier, Manuella; Najioullah, Fatiha; Vouga, Manon; Voluménie, Jean-Luc; Baud, David

doi:10.1016/s2352-4642(17)30001-9

Cited by 38 publications

(97 citation statements)

References 29 publications

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“…Abnormal neuronal migration and disorders of cortical development are visualized by reduction in gyration (pachy/agyria), polymicrogyria, heterotopias, and subsequent microcephaly . Malformations of cortical development were described in 79% to 82% of CZS cases . In addition, destructive cystic diseases such as porencephaly, schizencephaly, or hydranencephaly are frequently observed because of necrosis of neural progenitors.…”

Section: Congenital Zikv Syndromesupporting

confidence: 53%

“…In our and others experience, microcephaly is always associated with other findings and seems to be the consequence of viral brain injury. Prevalence of microcephaly in CZS is 33.3% to 64 %, but brain volume loss seems to be much more frequent (92% of cases) …”

Section: Congenital Zikv Syndromementioning

confidence: 99%

“…Ventriculomegaly associated with ZIKV is probably related to the atrophic brain, peri‐ventricular, and germinative necrosis, as suggested by the thin cortical mantle frequently observed. Prevalence of ventriculomegaly in CZS is 63.1% to 92% …”

Section: Congenital Zikv Syndromementioning

confidence: 99%

“…These calcifications are often weakly echogenic without any posterior shadowing on prenatal US and can intensify in echogenicity and size during pregnancy, which may lead to multiple punctiform macro‐calcifications . Prevalence of calcifications in CZS is 71% to 92% …”

Section: Congenital Zikv Syndromementioning

confidence: 99%

“…Dysgenesis of the corpus callosum is frequently described including partial or complete agenesis and callosal calcifications . Prevalence of malformations of the corpus callosum range between 71% and 100% …”

Section: Congenital Zikv Syndromementioning

confidence: 99%

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Zika virus during pregnancy: From maternal exposure to congenital Zika virus syndrome

et al. 2019

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What is already known about the topic? The Zika virus (ZIKV) emergence and its consequences during pregnancy led to an increasing number of data about the maternal and fetal consequences of ZIKV infections. What does this study add? This review evaluates risks of maternal ZIKV infection, maternal‐fetal transmission, congenital Zika syndrome (CZS), other adverse perinatal outcomes, and long‐term sequelae among pregnancies exposed to ZIKV. This review also provides contemporary criteria and guidelines for the follow‐up of exposed fetuses, based on prenatal and postnatal features of CZS.

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Section: Congenital Zikv Syndromesupporting

confidence: 53%

Section: Congenital Zikv Syndromementioning

confidence: 99%

Section: Congenital Zikv Syndromementioning

confidence: 99%

Section: Congenital Zikv Syndromementioning

confidence: 99%

Section: Congenital Zikv Syndromementioning

confidence: 99%

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Zika virus during pregnancy: From maternal exposure to congenital Zika virus syndrome

et al. 2019

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Obstetric and perinatal outcomes in cases of congenital Zika syndrome

Melo

Tavares²,

Costa³

et al. 2020

Prenatal Diagnosis

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Objective: To describe obstetric and perinatal outcomes in cases of congenital Zika syndrome (CZS). Methods: A dual prospective and retrospective cohort study involving 102 pairs of mothers and fetuses/children with CZS whose infection was confirmed by testing for the Zika virus in amniotic fluid, umbilical cord blood, and fragments from the placenta of the newborn infant (confirmed CZS), or by intrauterine imaging tests (neurosonography), and/or postnatal computed tomography (presumed CZS). Results: Suspicion of CZS was investigated by ultrasonography during pregnancy in 52.9% of cases. The principal prenatal imaging findings were ventriculomegaly (43.1%) and microcephaly (42.2%). Median gestational age at delivery was 39 weeks, with 15.7% being premature. Mean head circumference at birth was 30.0 ± 2.3 cm, with 66% of cases being classified as having microcephaly. Arthrogryposis was found in 10 cases (9.8%). There were no fetal deaths; however, nine neonatal deaths were recorded, and three autopsies were performed. Conclusion: Neonatal mortality was high, almost 10%. Regarding the abnormalities of CZS, microcephaly, although common, was not present in all cases and intracranial findings need to be taken into consideration for diagnosis. Therefore, ultrasound screening during pregnancy should be systematized and expanded in endemic zones.

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