Ultrasound-Guided Transesophageal High-Intensity Focused Ultrasound Cardiac Ablation in a Beating Heart: A Pilot Feasibility Study in Pigs

Bessière, Francis; N’Djin, W. Apoutou; Colas, Elodie Constanciel; Chavrier, F.; Greillier, Paul; Chapelon, Jean Yves; Chevalier, Philippe; Lafon, Cyril

doi:10.1016/j.ultrasmedbio.2016.03.007

Cited by 25 publications

(17 citation statements)

References 42 publications

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“…Since the esophagus is located just behind the heart, it offers a perfect acoustic window so that HIFU can be directed toward the heart without many acoustic fences (Ho & Ernst 2012) so this technology could allow treating foci without intravascular catheter. One of these approach is actually under feasibility study on animal testing (Bessiere, N'djin, Colas, Chavrier, Greillier, Chapelon, Chevalier & Lafon 2016). The probe is combining both a multielement HIFU and ultrasound (US) transducers so that HIFU therapy can be delivered in real time under US 2D anatomy imaging.…”

Section: Introductionmentioning

confidence: 99%

Transesophageal 2D ultrasound to 3D computed tomography registration for the guidance of a cardiac arrhythmia therapy

Sandoval¹,

Castro²,

Alirezaie³

et al. 2018

Phys. Med. Biol.

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The work aims to develop a new image-processing method to improve the guidance of transesophageal high intensity focused ultrasound (HIFU) atrial fibrillation therapy. Our proposal is a novel registration approach that aligns intraoperative 2D ultrasound with preoperative 3D-CT information. This approach takes advantage of the anatomical constraints imposed at the transesophageal HIFU probe to simplify the registration process. Our proposed method has been evaluated on a physical phantom and on real clinical data.

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Section: Introductionmentioning

confidence: 99%

Transesophageal 2D ultrasound to 3D computed tomography registration for the guidance of a cardiac arrhythmia therapy

Sandoval¹,

Castro²,

Alirezaie³

et al. 2018

Phys. Med. Biol.

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“…Different studies have already illustrated the possibility to use HIFU for pre-clinical and clinical cardiac applications such as: treatment of arrhythmias [36,37], atrial septostomy [38] or atrio-ventricular nodal-ablation in dogs [39]. Therefore, the developed 4-D US platform can be considered as dual-mode, imaging and therapy.…”

Section: Discussionmentioning

confidence: 99%

Fast Volumetric Ultrasound B-Mode and Doppler Imaging with a New High-Channels Density Platform for Advanced 4D Cardiac Imaging/Therapy

et al. 2018

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Abstract:A novel ultrasound (US) high-channels platform is a pre-requisite to open new frontiers in diagnostic and/or therapy by experimental implementation of innovative advanced US techniques. To date, a few systems with more than 1000 transducers permit full and simultaneous control in both transmission and receiving of all single elements of arrays. A powerful US platform for implementing 4-D (real-time 3-D) advanced US strategies, offering full research access, is presented in this paper. It includes a 1024-elements array prototype designed for 4-D cardiac dual-mode US imaging/therapy and 4 synchronized Vantage systems. The physical addressing of each element was properly chosen for allowing various array downsampled combinations while minimizing the number of driving systems. Numerical simulations of US imaging were performed, and corresponding experimental data were acquired to compare full and downsampled array strategies, testing 4-D imaging sequences and reconstruction processes. The results indicate the degree of degradation of image quality when using full array or downsampled combinations, and the contrast ratio and the contrast to noise ratio vary from 7.71 dB to 2.02 dB and from 2.99 dB to −7.31 dB, respectively. Moreover, the feasibility of the 4-D US platform implementation was tested on a blood vessel mimicking phantom for preliminary Doppler applications. The acquired data with fast volumetric imaging with up to 2000 fps allowed assessing the validity of common 3-D power Doppler, opening in this way a large field of applications.

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“…Ultrasound-guided HIFU is an alternative to other ablation techniques [3]. HIFU energy can be used to create thermal propagation path [4] without damaging the intervening tissues.…”

Section: Introductionmentioning

confidence: 99%

“…Transesophageal HIFU cardiac fibrillation therapy is a mini-invasive treatment that places the HIFU transducer close to the ablation zone by navigating inside the esophagus, the probe navigation and transducer positioning is carry out using an embedded ultrasound (US) imaging system [4], [5]. As any mini-invasive procedure, first a therapy planning (the ablation path) is defined on a high-resolution anatomical preoperative 3D imaging (CT/MRI).…”

Section: Introductionmentioning

confidence: 99%

High Intensity Focused Ultrasound Therapy Guidance System by Image-based Registration for Patients with Cardiac Fibrillation

Dahman¹,

Dillenseger²

2019

2019 Computing in Cardiology Conference (CinC)

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Transesophageal high-intensity focused ultrasound (HIFU) energy can be used to treat cardiac arrhythmia efficiently non-invasively. Since the esophagus is located just behind the heart, it offers a perfect acoustic window. Hence, HIFU can be directed toward the heart to perform ablation. In a previous study a HIFU probe with one 2D US image perpendicular to the esophagus axis for guidance purpose has been proposed. A new dual-mode HIFU probe with two perpendicular 2D US imaging plane is now under development. In this paper we propose a therapy guidance system, based on an intensity-based registration of the two perpendicular 2D US to preoperative 3D CT. As a proof of concept we developed the following evaluation framework on a numerical phantom: 1) we define a ground truth (GT) initial pose inside a CT volume and simulated two perpendicular US images from the CT data; 2) we run the registration framework from 55 randomly defined pose initializations around the initial GT pose; and 3) we estimated the accuracy of the registration by (a) the transformation parameter estimation errors and (b) Target Registration Error (TRE).

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Ultrasound-Guided Transesophageal High-Intensity Focused Ultrasound Cardiac Ablation in a Beating Heart: A Pilot Feasibility Study in Pigs

Cited by 25 publications

References 42 publications

Transesophageal 2D ultrasound to 3D computed tomography registration for the guidance of a cardiac arrhythmia therapy

Transesophageal 2D ultrasound to 3D computed tomography registration for the guidance of a cardiac arrhythmia therapy

Fast Volumetric Ultrasound B-Mode and Doppler Imaging with a New High-Channels Density Platform for Advanced 4D Cardiac Imaging/Therapy

High Intensity Focused Ultrasound Therapy Guidance System by Image-based Registration for Patients with Cardiac Fibrillation

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