To investigate the value of ultrasound-guided brachial plexus combined with superficial cervical plexus nerve block anesthesia in the surgery of patients with mid-clavicular fracture. Eighty patients with mid-clavicular fractures admitted to a hospital from January 2020 to December 2022 were selected for the study, and they were randomly divided into a control group and a study group, 40 patients in each group, and both groups were treated with internal fixation of clavicular fractures. The anesthetic effect and anesthesia, heart rate and blood pressure at different time points, serum adrenocorticotropic hormone (ACTH) and cortisol (Cor) levels before surgery and at the time of fracture reduction, and postoperative complications were compared between the two groups. The anesthetic effect of the study group was significantly better than that of the control group (P<0.05); the onset of anesthesia and sensory block were longer (P<0.05) and the recovery time of sensation was shorter (P<0.05) in the control group than in the study group; there was no significant difference between the heart rate and blood pressure of the two groups before anesthesia (P>0.05), and the heart rate and blood pressure of the control group at the time of stripping the periosteum, at the end of surgery and at 10 min after surgery were significantly different. The heart rate and blood pressure of the control group were higher than those of the study group at the time of stripping the periosteum, at the end of surgery and 10 min after surgery (P<0.05); before surgery, there was no significant difference in ACTH and Cor levels between the two groups (P>0.05), and after fracture reduction, ACTH and Cor levels increased in both groups, and the control group was higher than the study group (P<0.05); the incidence of postoperative complications was significantly higher in the control group than in the study group. The incidence of postoperative complications in the control group was significantly higher than that in the study group. Ultrasound-guided brachial plexus nerve combined with superficial cervical plexus nerve block anesthesia is effective in patients with mid-clavicular fracture, which can significantly improve the anesthetic effect, shorten the anesthesia time and sensory block onset time, prolong the sensory recovery time, maintain the stability of vital signs and hemodynamics, and reduce the incidence of postoperative complications, and has high application value and promotion significance.