Introduction: Stellate ganglion block (SGB) is used for the treatment of many vascular disorders and sympathetically mediated pain including pain of head, neck, cancer, phantom, postherpetic neuralgia, cardiac arrythmia, orofacial pain, and vascular headache. Various modalities to localize stellate ganglion use of fluoroscopy, computerized tomography, magnetic resonance imaging, and radionucleotide tracers. Ultrasound imaging is a best tool for SGB due to its clarity, low cost, lack of radiation and portability. In this study we aimed to compare the efficacy of fluoroscopy vs ultrasound guided stellate ganglion block in lowering the pain using numeric rating scale (NRS). Material and Methods: Study was perform in 40 patients suffering from upper limb and head and neck, neuropathic pain. The first group (Group I) received stellate ganglion block under ultrasound guidance while the second group (Group II) received stellate ganglion block under fluoroscopy guidance. The t-test and Man Whitney test were perform to analyses the data. Results: The requirement of different analgesia were comparable in both group I and group II patients. Change in pain score was maximum at immediate post-block, 1 h postblock, 6 h post block (65.84% of baseline) while change was minimum at 48 h post-block (48.45% of baseline). The pain was significantly lower in group I from baseline as compared to group II at all periods. Range of Ease rating score were also lower in group I. Block was statistically achieved earlier in Group I (4.55±0.69 min) as compared to Group II (12.60±2.56 min). Conclusion: USG and fluoroscopy are both good techniques for stellate ganglion block, but due to less complication, early blocking effect time, more precise placement of medication ultrasound guided block is preferred over fluoroscopy method.